A5026955752- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Superconducting Materials and Applications
- Microstructure and Mechanical Properties of Steels
- Spacecraft and Cryogenic Technologies
- Organ Transplantation Techniques and Outcomes
- Hydrogen embrittlement and corrosion behaviors in metals
- Advanced Thermodynamic Systems and Engines
- Welding Techniques and Residual Stresses
- Immunotherapy and Immune Responses
- Macrophage Migration Inhibitory Factor
- CAR-T cell therapy research
- Metal Alloys Wear and Properties
- High voltage insulation and dielectric phenomena
- Microstructure and mechanical properties
- Complement system in diseases
- Immunodeficiency and Autoimmune Disorders
- Heat Transfer and Optimization
- Calibration and Measurement Techniques
- MicroRNA in disease regulation
- Organ Donation and Transplantation
- High Entropy Alloys Studies
- Advanced Sensor and Energy Harvesting Materials
- Fatigue and fracture mechanics
Brigham and Women's Hospital
2020-2025
Harvard University
2020-2025
Technical Institute of Physics and Chemistry
2017-2024
Chinese Academy of Sciences
2017-2024
Xiamen University
2023-2024
Australian National University
2024
Nanjing Medical University
2018-2023
Jiangsu Province Hospital
2019-2023
University of Chinese Academy of Sciences
2017
Follicular helper T (Tfh) cells promote, whereas follicular regulatory (Tfr) restrain, germinal center (GC) reactions. However, the precise roles of these in complex GC reaction remain poorly understood. Here, we perturb Tfh or Tfr after SARS-CoV-2 spike protein vaccination mice. We find that promote frequency and somatic hypermutation (SHM) Spike-specific B regulate clonal diversity. similarly control SHM diversity but do so by limiting competition. In addition, deletion during primary...
Allograft interstitial fibrosis was characterized by massive extracellular matrix deposition caused activated fibroblasts and myofibroblasts. Epithelial-mesenchymal transition (EMT) is recognized as an important source of myofibroblasts contributing to the pathogenesis allograft fibrosis. Smad ubiquitination regulatory factor 1 (Smurf1) has been recently reported be involved in progression EMT. Our study detect effect Bortezomib Smurf1 EMT Biomarkers EMT, well Smurf1, were examined human...
Follicular helper T (Tfh) cells are essential for the formation of high affinity antibodies after vaccination or infection. Although signals responsible initiating Tfh differentiation from naïve have been studied, controlling sequential developmental stages culminating in optimal effector function not well understood. Here we use fate mapping strategies cytokine IL-21 to uncover including a progenitor-like stage, fully developed stage and post-effector that maintains transcriptional...
Pathogenic antibodies produced by alloreactive B cells mediate antibody-mediated rejection after kidney transplantation, but the mechanisms remain poorly understood. Follicular regulatory T (Tfr) modulate follicular helper cell-mediated cell responses, functions of Tfr in controlling antibody are unknown. Here we study developmental signals and mouse allogeneic transplantation models, show that costimulatory blockade alters development disproportionately decreasing germinal center (GC)-like...
The microRNA (miRNA) miR-200c-3p is involved in the tumorigenesis and progression of a variety cancers. However, underlying regulatory role prostate cancer (PCa) remains unclear.Online databases including Oncomine, Linkedomics StarBase were used to investigate clinical significance miR-200c-3p, along with associated gene targets. PCa tissues adjacent normal for detection expression. A lentivirus overexpressing was constructed transfected into PC3 DU145 cells. Cell formation proliferation,...
Carbon-based aerogels have drawn substantial attention for a wide scope of applications. However, the high intrinsic electrical conductivity limits their potential thermal management application in electronic packaging materials. Herein, highly compressible, thermally conductive, yet electrically insulating fluorinated graphene aerogel (FGA) is developed through hydrofluoric acid-assisted hydrothermal process. The macroscopic-assembled FGA constituting tailored interconnected networks with...
Follicular helper T (Tfh) cells have been implicated in controlling rejection after allogeneic kidney transplantation, but the precise subsets, origins, and functions of Tfh this process not fully characterized. Here we show that a subset effector marked by previous IL-21 production is potently induced during transplantation inhibited immunosuppressive agents. Single-cell RNA-Seq revealed these lymph node (LN) transcriptional clonal overlap with IL-21-producing kidney-infiltrating cells,...
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate tolerance induced by anti-CD40L in a murine model heart We found that both absence LNs FRC depletion abrogated effect prolonging allograft survival. Depletion FRCs impaired homing T across high endothelial venules (HEVs) promoted formation alloreactive heart-transplanted mice treated with anti-CD40L. Single-cell RNA...
Abstract Acute rejection is a major risk for renal transplant failure. During this adverse process, activated T cells are considered the main effectors. Recently, B and lymphocyte attenuator (BTLA), member of CD28 family receptor, was reported to be novel inhibitory regulator cell activation in heart pancreatic allograft rejection. Due similarity acute pathways among different organs, we hypothesized that BTLA might play role kidney transplant. In patients, observed expression significantly...
Background Costimulatory blockade provides new therapeutic opportunities for ensuring the long-term survival of kidney grafts. The adoption novel immunosuppressant Belatacept has been limited, partly due to concerns regarding higher rates and grades acute rejection in clinical trials. In this study, we hypothesized that a combined therapy, with BTLA overexpression, may effectively attenuate after transplantation. Materials Methods rat transplantation model was used investigate graft single...
Background. Following allogeneic kidney transplantation, a substantial proportion of graft loss is attributed to the formation donor-specific antibodies and antibody-mediated rejection. B cells infiltrate grafts during rejection; however, origins, repertoires, functions these intrarenal remain elusive. Methods. Here, we use murine transplant models study transcriptional programming cell receptor repertoire intragraft cells, in vitro stimulation assays evaluate ability promote CD4+ T...
Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal transplantation. In our previous study, we found that epithelial–mesenchymal transition (EMT) a significant event progression tubulointerstitial fibrosis, and impaired autophagic flux plays critical role fibrosis. Everolimus (EVR) has been reported to be widely used prevent organ fibrosis rejection. However, pharmacological mechanism EVR kidney transplantation remains determined. We CAD rat model...
In this work, the microstructure evolution and magnetic properties of 316LN austenitic stainless steels under high-cycle-fatigue loading at liquid helium temperature (4.2 K) were assessed by using X-ray diffractometer (XRD), electron microscopy measurements. The was composed a single face-centered cubic (FCC) phase, high local misorientation found near grain boundaries. Observations through high-resolution transmission reveals that deformation dominated dislocation stacking faults....
The present work describes the monitoring system of real-time strain response on curing process epoxy resin from initial point to end, and change in during temperature changes. A simple mould was designed embed gauge, thermometer, quartz standard sample into resin, so that were simultaneously measured recorded. cryogenic-grade tested Differential Scanning Calorimetry (DSC) used analyse process. Based DSC results, three processes adopted investigate their influence as well residual resin....