A5001441705- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Renal Transplantation Outcomes and Treatments
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
Brigham and Women's Hospital
2019-2024
Harvard University
2019-2024
Tufts Medical Center
2024
Minia University
2019-2023
Cancer cells program fibroblasts into cancer associated (CAFs) in a two-step manner. First, secrete exosomes to quiescent activated CAFs. Second, maintain the CAF phenotype via activation of signal transduction pathways. We rationalized that inhibiting this process can normalize CAFs and augment efficacy immunotherapy. show cell–targeted nanoliposomes inhibit sequential steps exosome biogenesis release from lung block differentiation In parallel, we demonstrate CAF-targeted two distinct...
Introduction Studies have shown reduced antiviral responses in kidney transplant recipients (KTRs) following SARS-CoV-2 mRNA vaccination, but data on post-vaccination alloimmune and against the Delta (B.1.617.2) variant are limited. Materials methods To address this issue, we conducted a prospective, multi-center study of 58 adult KTRs receiving mRNA-BNT162b2 or mRNA-1273 vaccines. We used multiple complementary non-invasive biomarkers for rejection monitoring including serum creatinine,...
The emergence of vaccine-evading SARS-CoV-2 variants urges the need for vaccines that elicit broadly neutralizing antibodies (bnAbs). Here, we assess covalently circularized nanodiscs decorated with recombinant spike glycoproteins from several eliciting bnAbs vaccination. Cobalt porphyrin-phospholipid (CoPoP) was incorporated into nanodisc to allow anchoring and functional orientation trimers on surface through their His-tag. Monophosphoryl-lipid (MPLA) QS-21 were as immunostimulatory...