A5013804319- Chronic Obstructive Pulmonary Disease (COPD) Research
- Transplantation: Methods and Outcomes
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- Inhalation and Respiratory Drug Delivery
- Pneumothorax, Barotrauma, Emphysema
- Smoking Behavior and Cessation
- Long-Term Effects of COVID-19
- Pleural and Pulmonary Diseases
- Venous Thromboembolism Diagnosis and Management
- COVID-19 diagnosis using AI
- Sleep and related disorders
- COVID-19 and Mental Health
- Retinal Development and Disorders
- Atrial Fibrillation Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Obstructive Sleep Apnea Research
Temple University
2019-2025
Temple University Hospital
2019-2024
Temple University Health System
2020
Drexel University
2012-2015
Hahnemann University Hospital
2014-2015
University of the Sciences
2008
Effective treatments for patients with severe COVID-19 are needed.To evaluate the efficacy of canakinumab, an anti-interleukin-1β antibody, in hospitalized COVID-19.This randomized, double-blind, placebo-controlled phase 3 trial was conducted at 39 hospitals Europe and United States. A total 454 pneumonia, hypoxia (not requiring invasive mechanical ventilation [IMV]), systemic hyperinflammation defined by increased blood concentrations C-reactive protein or ferritin were enrolled between...
Invasive mechanical has been associated with high mortality in COVID-19. Alternative therapy of flow nasal (HFNT) greatly debated around the world for use COVID-19 pandemic due to concern increased healthcare worker transmission.This was a retrospective analysis consecutive patients admitted Temple University Hospital Philadelphia, Pennsylvania, from 10 March 2020 24 April moderate-to-severe respiratory failure treated HFNT. Primary outcome prevention intubation. Of 445 COVID-19, 104 met our...
Alpha 1 Antitrypsin Deficiency (AATD) is a genetic condition that results from mutations in the SERPINA1 gene, which can lead to deficient or dysfunctional (AAT) protein production. AATD linked chronic obstructive pulmonary disease (COPD) and emphysema. In addition manifestations, has also been associated with vascular pathology due excessive protease activity, tissue degradation, vessel stiffening. Early diagnosis crucial prevent progressive lung damage pathologies. Here, we present case...
Buprenorphine is a partial opioid agonist effective for the treatment of use disorder. However, precipitated withdrawal remains barrier to its initiation. As disorder and related complications continue at alarming rates, it crucial evaluate alternative means initiating this lifesaving medication whenever patients interact with health care system. In case report, we discuss patient who completed low-dose buprenorphine initiation while intubated sedated in an intensive setting, setting recent...
Infection with the novel severe acute respiratory syndrome coronavirus 2 has been associated a hypercoagulable state. Emerging data from China and Europe have consistently shown an increased incidence of venous thromboembolism (VTE). We aimed to identify VTE early predictors at our high-volume tertiary care center.We performed retrospective cohort study 147 patients who had admitted Temple University Hospital disease 2019 (COVID-19) April 1, 2020 27, 2020. first identified (pulmonary...
The use of high-flow nasal therapy (HFNT) to treat COVID-19 pneumonia has been greatly debated around the world due concerns about increased health care worker transmission and delays in invasive mechanical ventilation (IMV). Herein, we analyzed utility noninvasive ROX (ratio oxygen saturation) index predict need for timing IMV.This study aimed assess whether can be a useful score intubation IMV patients receiving HFNT as treatment COVID-19-related hypoxemic respiratory failure.This is...
Atonal is a Drosophila proneural protein required for the proper formation of R8 photoreceptor cell, founding cell in developing retina. Proper expression and refinement essential adult eye. In vertebrates, transcription factors orthologous to (MATH5/Atoh7, XATH5, ATH5) their progressive restriction are also involved specifying retinal ganglion neural type mammalian Thus, identifying that regulating during development important fully understand how neurogenesis accomplished. We have...
Abstract Use of high flow nasal therapy (HFNT) to treat COVID-19 pneumonia has been greatly debated around the world due concern for increased healthcare worker transmission and delays in invasive mechanical Ventilation (IMV). Methods A retrospective analysis consecutive patients admitted Temple University Hospital Philadelphia, Pennsylvania, from March 10, 2020, May 17, 2020 with moderate severe respiratory failure treated High Flow (HFNT). HFNT were divided into two groups: only progressed...
Background Pulmonary hypertension (PH) causes increased morbidity and mortality in patients with interstitial lung diseases (ILD). Classification schemes, while well-characterised for the vasculopathy of idiopathic PH, have been applied, unchallenged, to ILD-related PH. We evaluated pulmonary arterial histopathology explanted human tissue from who were transplanted advanced fibrotic ILD. Methods Lung explants 38 adult underwent transplantation included. Patients divided into three groups:...
The Lung Allocation Score (LAS) prioritises lung transplantation candidates, balancing waitlist mortality and post-transplant survival. score groups sarcoidosis candidates based on mean pulmonary artery pressure: those with ≤30 mmHg (sarcoidosis A) are grouped COPD >30 D) idiopathic fibrosis (IPF). We hypothesise that have a higher than other within their LAS grouping.This is retrospective cohort study of consecutive from the Scientific Registry Transplant Recipients database May 2005 to...
Abstract Background COVID-19 can lead to acute respiratory failure and an exaggerated inflammatory response. Studies have suggested promising outcomes using monoclonal antibodies targeting IL-1β (Anakinra) or IL6 (Tocilizumab), however no head comparison was done between the two treatments. Herein, we report our experience in treating pneumonia associated with cytokine storm either subcutaneous Anakinra given concomitantly intravenous immunoglobulin (IVIG), Tocilizumab. Methods Comprehensive...
Introduction Use of high flow nasal therapy (HFNT) to treat COVID-19 pneumonia has been greatly debated around the world due concern for increased healthcare worker transmission and delays in invasive mechanical Ventilation (IMV). Herein we analyze utility ROX index predict need timing IMV a retrospective analysis patients with moderate severe hypoxemic respiratory failure treated HFNT. Methods This was 129 consecutive admitted Temple University Hospital Philadelphia, Pennsylvania, from...
We report a case of TTP in sickle cell/β+-thalassemia heterozygote with nonspecific complaints and evidence hemolysis, initially attributed to crisis. Included this is discussion the development functional hyposplenism, rarely reported complication, limitation ADAMTS-13 diagnosis, use platelet transfusion.
Proper neurogenesis in the developing Drosophila retina requires regulated expression of basic helix-loop-helix (bHLH) proneural transcription factors Atonal (Ato) and Daughterless (Da). Factors that control timing spatial these bHLH genes are required for proper formation function adult eye nervous system.Here we report lilliputian (lilli), homolog FMR2/AF4 family proteins, regulates ato da fly retina. We find lilli controls at multiple enhancer elements. also contributes to auto-regulation...
Abstract Invasive mechanical has been associated with high mortality in COVID-19. Alternative therapy of High flow nasal (HFNT) greatly debated around the world for use COVID-19 pandemic due to concern increased healthcare worker transmission. Methods This was a retrospective analysis consecutive patients admitted Temple University Hospital Philadelphia, Pennsylvania, from March 10, 2020, April 24, 2020 moderate severe respiratory failure treated Flow (HFNT). Primary outcome prevention...
Background: Patients with chronic obstructive pulmonary disease (COPD) are at higher risk for severe coronavirus 2019 (COVID-19). From the pandemic’s onset there has been concern regarding effects on health and well-being of high-risk patients. Methods: This was an ancillary study to