A5018394028- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Histiocytic Disorders and Treatments
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Glioma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Sarcoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Autoimmune and Inflammatory Disorders Research
- Cutaneous lymphoproliferative disorders research
- Cancer Diagnosis and Treatment
- Complement system in diseases
- Cardiovascular Function and Risk Factors
- Vascular Malformations and Hemangiomas
- RNA modifications and cancer
- Soft tissue tumor case studies
- Neuroendocrine Tumor Research Advances
- Virus-based gene therapy research
- Colorectal and Anal Carcinomas
Imperial College Healthcare NHS Trust
2025
Temple University Hospital
2014-2024
University Health System
2023
Temple University Health System
2023
Temple University
2014-2021
Hospital of the University of Pennsylvania
2014
New York University
2012
The University of Texas MD Anderson Cancer Center
2010-2012
OU Health
2011
University of Oklahoma
2011
We reviewed FLT3 and NPM1 mutation data in a large cohort of patients with myelodysplastic syndrome (MDS). The frequencies were 2.0% 4.4%, respectively, mutations restricted to cases intermediate- high-risk MDS. Cytogenetic abnormalities identified 46.9% cases. associated complex karyotype (P = .009), whereas diploid < .001). .001) was progression acute myeloid leukemia (AML), as higher bone marrow (BM) blast count cytogenetics .039). No patient an alone had disease that progressed AML. Cox...
Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) both belong to the group of disorders, which have varied prognostic clinical significance. Their normal cellular counterparts share a common CD34-positive hematopoietic stem precursor that matures along CD14-negative or -positive pathways. Rare cases LCH JXG show overlapping findings, suggesting this divergent maturation is not irreversible. We report case an infant diagnosed with cutaneous shortly after birth. Two years...
Abstract Acute myeloid leukemia (AML) with isolated trisomy 4 is rare. Associations KIT mutations on chromosome 4q12 have been documented. The clinicopathologic features and mutational status of KIT, FLT3, NPM1, CEBPA, RAS were assessed in 13 AML cases 4. There 9 men women a median age 54 years. Median blast count was 84% (range, 24%–93%). Morphologic varied across five 2008 World Health Organization categories. FLT3 (5/10) NPM1 (4/10) observed at frequency similar to normal-karyotype cases....
Primary mediastinal large B-cell lymphoma (PMBCL) is a rare type of non-Hodgkin that typically has good response rate to first line chemotherapy regimens. There have been reports successful chemotherapy, but with residual mass from fibrosis. Here, we report the case 19-year-old primigravida presenting cardiogenic shock and superior vena cava (SVC) syndrome at full term who was found PMBCL. Following delivery via urgent cesarean section, she put on veno-arterial extra corporeal membrane...
Rosai–Dorfman disease (RDD) is a rare idiopathic benign proliferative disorder of histiocytes. RDD typically presents with cervical lymph node involvement; however, extranodal sites such as the breast can also be involved and should prompt evaluation for additional disease.
Large clonal populations of cells bearing PIG-A mutations are the sine qua non PNH, but mutation itself is insufficient for expansion. The association between PNH and aplastic anemia supports immune escape model, not all patients demonstrate a history aplasia; therefore, second genetic hits driving expansion have been postulated. Based on previous identification JAK2 in with myeloproliferative/PNH overlap syndrome, we considered TET2 as candidate gene which might be contributing to...
T-cell lineage lymphoma with an intense membranous and paranuclear CD30 expression in the absence of ALK1 raises a differential diagnosis peripheral (PTCL), NOS anaplastic large cell (ALCL), ALK negative. However, Epstein-Barr virus is consistently negative ALCL not considered implicating factor its pathogenesis. We describe case showing morphology scattered hallmark cells uniform encoded early RNA (EBER) that primarily involved subcutaneous tissue at presentation. On incisional biopsy,...
Mucosa-associated lymphoid tissue (MALT) lymphoma is predominantly found in the stomach. Rarely, it proximal colon and even less so sigmoid colon. We present a rare case of primary MALT patient with concomitant Helicobacter pylori hepatitis C infection. also review current imaging, staging, therapeutic modalities. To our knowledge, this first reported United States.
Objective:Rare disease Background:Non-IgM lymphoplasmacytic lymphoma (LPL) is a rare subtype of LPL, constituting less than 5% the cases, and often associated with IgG, IgA, or light chain paraproteins rarely non-secretor.Non-IgM LPL remains poorly studied, differential diagnosis from other small B-cell lymphomas plasmacytic differentiation plasma cell neoplasm challenging. Case Report:A 67-year-old woman presented weight loss, persistent anemia, borderline leukopenia.Serum protein...
Introduction: The gastrointestinal tract is the most common extranodal site for non-Hodgkin's lymphoma, with being diffuse large B cell lymphoma. Unlike stomach or ileum, jejunum a rare primary lymphomas, given scarcity of lymphoid tissue. Due to its location, inflammation in may not be visualized on routine imaging endoscopy, making jejunal lymphoma difficult diagnose. Case Description: We present case 90-year-old male 1 week intractable emesis, initially thought due viral gastroenteritis....
Anaplastic lymphoma kinase (ALK)-positive large B-cell (LBCL) is a very rare type of LBCL with an aggressive clinical course and poor prognosis. This diagnosis can be challenging given the varied morphology (immunoblastic, plasmablastic, or anaplastic), frequent lack antigens, especially in cases expression epithelial antigens. Here, we report case ALK-positive unusual 4 epithelial-associated markers (AE1/AE3, CK8/18, EMA, GATA3) novel poly(A) binding protein cytoplasmic 1 (PABPC1) :: ALK...
Post-Transplant Lymphoproliferative Disorders (PTLD) is mostly of B-cell origin."Composite" PTLD with diffuse large lymphoma (DLBCL) and T/ anaplastic cell component are extremely rare.We report a case after heart transplant two distinct components.The patient was initially diagnosed monomorphic PTLD/DLBCL, EBV negative involving the intestinal wall, occurring nine years transplantation.Sixteen post-transplant, recurred intestine showed components: DLBCL strong homogeneous expression CD45...
Primary dural lymphoma (PDL) usually arises from the calvarial dura without brain parenchyma or systemic involvement and thus may not be considered as a typical form of primary CNS (PCNSL). It is exceedingly rare. When it occurs, might suspected diagnosis on clinical radiologic findings. We present PDL case that occurs at cerebellopontine (CP) angle mimicking en plaque meningioma. The tumor histopathology showed lymphoproliferative disorder immunophenotypically consistent with low-grade...
We describe the prognostic implication and aggressive clinical course of lymphoma-related lactic acidosis in a rare HIV-related lymphoma. Patient was diagnosed with plasmablastic lymphoma developed severe acidosis, treated on medical floor intensive care unit. Her considered to be type B, secondary her underlying since she never had an infectious source, hypovolemic state, or low/high cardiac-output state. The mechanism is from altered cellular metabolism, thought aid proliferation, rather...