A5018486008- Cardiovascular and exercise physiology
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Vitamin D Research Studies
- Blood Pressure and Hypertension Studies
- IL-33, ST2, and ILC Pathways
- Body Composition Measurement Techniques
- Renal function and acid-base balance
- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Cardiac Fibrosis and Remodeling
- Vitamin C and Antioxidants Research
- Cardiac Ischemia and Reperfusion
- Congenital heart defects research
- Intensive Care Unit Cognitive Disorders
- Nutrition and Health in Aging
- Long-Term Effects of COVID-19
- Coronary Interventions and Diagnostics
- Pharmacology and Obesity Treatment
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Cardiovascular Effects of Exercise
Virginia Commonwealth University
2018-2022
Virginia Commonwealth University Medical Center
2018-2020
Effective treatments for patients with severe COVID-19 are needed.To evaluate the efficacy of canakinumab, an anti-interleukin-1β antibody, in hospitalized COVID-19.This randomized, double-blind, placebo-controlled phase 3 trial was conducted at 39 hospitals Europe and United States. A total 454 pneumonia, hypoxia (not requiring invasive mechanical ventilation [IMV]), systemic hyperinflammation defined by increased blood concentrations C-reactive protein or ferritin were enrolled between...
The NLRP3 inflammasome has been implicated in the development and progression of heart failure. aim this study was to determine safety an oral inhibitor inflammasome, dapansutrile (OLT1177), patients with failure reduced ejection fraction (HFrEF). This a phase 1B, randomized, double-blind, dose escalation, single-center, repeat pharmacodynamics stable HFrEF (New York Heart Association Class II-III). Subjects were randomized treatment for up 14 days at ratio 4:1 into 1 3 sequential ascending...
Dilated cardiomyopathy (DCM) is frequently caused by genetic factors. Studies identifying deleterious rare variants have predominantly focused on early-onset cases, and little known about the underpinnings of growing numbers patients with DCM who are diagnosed when they older than 60 years (ie, late-onset DCM).To investigate prevalence, type, prognostic impact disease-associated in DCM.A population had undergone testing 7 international tertiary referral centers worldwide were enrolled from...
Abstract Background Heart failure (HF) is a global leading cause of mortality despite implementation guideline directed therapy which warrants need for novel treatment strategies. Proof-of-concept clinical trials anakinra, recombinant human Interleukin-1 (IL-1) receptor antagonist, have shown promising results in patients with HF. Method We designed single center, randomized, placebo controlled, double-blind phase II randomized trial. One hundred and two adult hospitalized within 2 weeks...
The small number of studies that have investigated the relationship between serum vitamin D levels and cardiorespiratory fitness (CRF) reported conflicting results. We association CRF in a representative sample US population using data from National Health Nutrition Survey (2001-2004).We included participants ages 20 49 years excluded those with at 5% extremes distribution. used survey-weighted linear regression without adjustment for age, sex, race, body mass index, hypertension, diabetes,...
Background: Modulation of the inflammatory response is a promising therapeutic strategy in acute myocardial infarction. The novel approach based on anti-inflammatory and cytoprotective properties mediated by engagement low-density lipoprotein‒related protein 1 (LRP1) receptor. SERPIN peptide 16 (SP16) synthetic, selective LRP1 agonist. We herein present results study with single subcutaneous administration SP16 10 patients STEMI, to appraise its safety tolerability explore effects response,...