A5042864155- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Cardiac Fibrosis and Remodeling
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Viral Infections and Immunology Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Mechanical Circulatory Support Devices
- Cardiac tumors and thrombi
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Lipoproteins and Cardiovascular Health
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Signaling Pathways in Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Cardiovascular Disease and Adiposity
- Cardiac Ischemia and Reperfusion
Virginia Commonwealth University
2016-2025
University of Illinois Chicago
2017-2024
University of Virginia
2023-2024
University of Chicago
2024
Virginia Commonwealth University Medical Center
2024
Sapienza University of Rome
2016-2023
Bon Secours Liver Institute of Richmond
2023
University Health System
2021-2023
Children's Hospital of Richmond at VCU
2017-2023
Università Cattolica del Sacro Cuore
2023
Background ST-segment-elevation myocardial infarction is associated with an intense acute inflammatory response and risk of heart failure. We tested whether interleukin-1 blockade anakinra significantly reduced the area under curve for hsCRP (high sensitivity C-reactive protein) levels during first 14 days in patients (VCUART3 [Virginia Commonwealth University Anakinra Remodeling Trial 3]). Methods Results conducted a randomized, placebo-controlled, double-blind, clinical trial 99 which were...
<h3>Importance</h3> Left ventricular (LV) thrombi can arise in patients with ischemic and nonischemic cardiomyopathies. Anticoagulation is thought to reduce the risk of stroke or systemic embolism (SSE), but there are no high-quality data on effectiveness direct oral anticoagulants (DOACs) for this indication. <h3>Objective</h3> To compare outcomes associated DOAC use warfarin treatment LV thrombi. <h3>Design, Setting, Participants</h3> A cohort study was performed at 3 tertiary care...
Background An enhanced inflammatory response predicts worse outcomes in heart failure (HF). We hypothesized that administration of IL-1 (interleukin-1) receptor antagonist (anakinra) could inhibit the and improve peak aerobic exercise capacity patients with recently decompensated systolic HF. Methods Results randomly assigned 60 reduced left ventricular ejection fraction (<50%) elevated C-reactive protein levels (>2 mg/L), within 14 days hospital discharge, to daily subcutaneous...
Background Enhanced inflammation may lead to exercise intolerance in heart failure with preserved ejection fraction. The aim of the current study was determine whether IL (interleukin)-1 blockade anakinra improved cardiorespiratory fitness Methods and Results Thirty-one patients fraction CRP (C-reactive protein) >2 mg/L were randomized (100 mg subcutaneously daily, N=21) or placebo (N=10) for 12 weeks. We measured peak oxygen consumption (Vo2), ventilatory efficiency (VE/Vco2 slope),...
Background: Heart failure is an inflammatory disease. Patients with acute decompensated heart (ADHF) exhibit significant activity on admission. We hypothesized that Interleukin-1 blockade, anakinra (Kineret, Swedish Orphan Biovitrum), would quench the response in patients ADHF. Methods: randomized 30 ADHF, reduced left ventricular ejection fraction (<40%), and elevated C reactive protein (CRP) levels (≥5 mg/L) to either 100 mg twice daily for 3 days followed by once 11 or matching placebo, a...
The NLRP3 inflammasome has been implicated in the development and progression of heart failure. aim this study was to determine safety an oral inhibitor inflammasome, dapansutrile (OLT1177), patients with failure reduced ejection fraction (HFrEF). This a phase 1B, randomized, double-blind, dose escalation, single-center, repeat pharmacodynamics stable HFrEF (New York Heart Association Class II-III). Subjects were randomized treatment for up 14 days at ratio 4:1 into 1 3 sequential ascending...
ST-segment elevation myocardial infarction (STEMI) is associated with an intense acute inflammatory response and increased risk of death heart failure (HF). In this study, we sought to evaluate the effect anakinra, a recombinant interleukin-1 receptor antagonist, on incidence HF.
Heart failure with preserved ejection fraction (HFpEF) is associated obesity and, indirectly, unhealthy diet. The role of dietary components in HFpEF is, however, largely unknown. In this study, the authors showed that obese patients, consumption unsaturated fatty acids (UFA), was better cardiorespiratory fitness, and UFA correlated diastolic function greater fat-free mass. Similarly, mice fed a high-fat diet rich low sugars had myocardial reduced weight gain. Randomized clinical trials...
Heart failure with preserved ejection fraction ( HFpEF ) now accounts for the majority of confirmed HF cases in United States. However, there are no highly effective evidence‐based treatments currently available these patients. Inflammation correlates positively adverse outcomes Interleukin IL )‐1, a prototypical inflammatory cytokine, has been implicated as driver diastolic dysfunction preclinical animal models and pilot clinical trial. The Diastolic Failure Anakinra Response Trial 2 (D‐...
Abstract Background Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome that presents clinicians diagnostic challenge. The use of natriuretic peptides to exclude diagnosis HFpEF has been proposed. We sought compare patients N‐terminal pro‐brain peptide (NT‐proBNP) level above and below the proposed cut‐off. Methods Stable ( n = 30) left ventricular (LV) ≥ 50% were eligible if they had HF according European Society Cardiology criteria. Characteristics NT‐proBNP...
Canagliflozin reduces hospitalizations for heart failure (HF) in type 2 diabetes mellitus (T2DM). Its effect on cardiorespiratory fitness and cardiac function patients with established HF reduced ejection fraction (HFrEF) is unknown.We conducted a double-blind randomized controlled trial of canagliflozin 100 mg or sitagliptin daily 12 weeks 88 patients, measured peak oxygen consumption (VO2 ) minute ventilation/carbon dioxide production (VE/VCO2 slope (co-primary endpoints repeated measure...
Sarcopenia impairs cardiorespiratory fitness (CRF) in patients with heart failure reduced ejection fraction (HFrEF). Obesity has also been shown to impair CRF; however, the effects of sarcopenia on CRF obesity and HFrEF are unknown. The aim this analysis was examine differences between sarcopenic (SO) non-SO (NSO) HFrEF. We assessed associations skeletal muscle mass index (SMMI) CRF.Forty underwent cardiopulmonary exercise testing collect measures including peak oxygen consumption (VO2),...
Abstract Leukocytosis is a common finding in patients with ST elevation myocardial infarction (STEMI) and portends poor prognosis. Interleukin 1-β regulates leukopoiesis pre-clinical studies suggest that anakinra (recombinant human interleukin-1 [IL-1] receptor antagonist) suppresses leukocytosis infarction. However, the effect of IL-1 blockade on leukocyte count STEMI unknown. We reviewed white blood cell (WBC) differential 99 enrolled clinical trial (n = 64) versus placebo 35) for 14 days...
Context Despite normalization of Thyrotropin (TSH), some patients with hypothyroidism treated Levothyroxine (LT4) report residual symptoms which may be attributable to loss endogenous triiodothyronine (T3). Objective Feasibility trial LT4/liothyronine (LT3) combination vs. LT4/placebo in post-surgical hypothyroidism. Design Double-blind, placebo-controlled, 24-week study. Setting Academic medical center Patients Individuals indications for total thyroidectomy and replacement therapy....