Clinton J. Thurber

ORCID: 0000-0003-3063-9262
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About
Contact & Profiles
Research Areas
  • Cardiac Arrhythmias and Treatments
  • Atrial Fibrillation Management and Outcomes
  • Cardiac electrophysiology and arrhythmias
  • Cardiac pacing and defibrillation studies
  • Cardiovascular Syncope and Autonomic Disorders
  • Cardiovascular Function and Risk Factors
  • Venous Thromboembolism Diagnosis and Management
  • Cardiac Imaging and Diagnostics
  • Cardiovascular Effects of Exercise
  • Ultrasound and Hyperthermia Applications
  • Acute Ischemic Stroke Management
  • Heart Rate Variability and Autonomic Control
  • Sarcoidosis and Beryllium Toxicity Research
  • Heart Failure Treatment and Management
  • Cardiac Fibrosis and Remodeling
  • S100 Proteins and Annexins
  • Digital Transformation in Industry
  • Nosocomial Infections in ICU
  • Exercise and Physiological Responses
  • Gastrointestinal Tumor Research and Treatment
  • Gastrointestinal Bleeding Diagnosis and Treatment
  • Kawasaki Disease and Coronary Complications
  • Pericarditis and Cardiac Tamponade
  • Child Abuse and Related Trauma
  • Telemedicine and Telehealth Implementation

Harvard University
2022-2024

Brigham and Women's Hospital
2022-2024

Nova Southeastern University
2019

Baylor Scott & White Medical Center - Temple
2018

Baylor Scott & White Health
2018

Virginia Commonwealth University
2015-2016

American Heart Association
2016

Istituto Neurologico Mediterraneo
2016

E Ink (South Korea)
2016

Sapienza University of Rome
2016

Background: Heart failure is an inflammatory disease. Patients with acute decompensated heart (ADHF) exhibit significant activity on admission. We hypothesized that Interleukin-1 blockade, anakinra (Kineret, Swedish Orphan Biovitrum), would quench the response in patients ADHF. Methods: randomized 30 ADHF, reduced left ventricular ejection fraction (<40%), and elevated C reactive protein (CRP) levels (≥5 mg/L) to either 100 mg twice daily for 3 days followed by once 11 or matching placebo, a...

10.1097/fjc.0000000000000378 article EN Journal of Cardiovascular Pharmacology 2016-02-23

Abstract Introduction Training in clinical cardiac electrophysiology (CCEP) involves the development of catheter handling skills to safely deliver effective treatment. Objective data from analysis ablation for evaluating trainee CCEP procedures has not previously been possible. Using artificial intelligence cloud‐based system (CARTONET), we assessed impact progress through procedural quality. Methods Lesion‐ and procedure‐level all de novo atrial fibrillation (AF) cavotricuspid isthmus (CTI)...

10.1111/jce.16349 article EN cc-by Journal of Cardiovascular Electrophysiology 2024-06-24

Vasovagal syncope (VVS) is a common phenomenon, with upwards of 30%–45% the population having suffered 1 VVS episode by age 60.1,2 It pathology that has frustrated many patients and providers in its suboptimal treatment response rate, enacted an outsized economic impact on western societies.3 subtypes are classified 3 broad categories: pure cardioinhibitory type (with without asystole); vasodepressor type, which hypotension occurs significant decrease heart rate (HR); mixed type.

10.1016/j.hrcr.2022.04.001 article EN cc-by HeartRhythm Case Reports 2022-04-06

Key Findings▪A cloud-based AI/machine learning system can be used to analyze detailed ablation data obtained during catheter ablation.▪This strategy allowed demonstration of predictors need for "touch up" pulmonary vein isolation.▪This approach may applied a broad range procedures and parameter analysis in the future. Catheter radiofrequency (RF) ablation–based isolation is predominant atrial fibrillation (AF). Attempts improve success rates have included real-time monitoring factors related...

10.1016/j.hroo.2022.03.006 article EN cc-by-nc-nd Heart Rhythm O2 2022-04-06

Consistent with a central role of the NALP3/NLRP3 in inflammatory injury during ischemia-reperfusion [11,12], colchicine 1.5 mg followed by 0.5 1 hour later and twice daily for 5 days significantly reduced size myocardial infarction patients ST-elevation AMI undergoing primary percutaneous coronary intervention [13] (Figures 2). The exciting results pilot studies require validation appropriately powered clinical trials. are however informative on tolerability or at risk it. gastrointestinal...

10.4172/2161-1025.1000e133 article EN cc-by Translational Medicine 2015-01-01

Background: The inflammatory response in acute decompensated heart failure (ADHF) may contribute to the progression of disease, complication, and re-hospitalization. Interleukin-1 (IL-1) has been identified as a potential therapeutic target HF. We hypothesized that IL-1 blockade, with Anakinra (Kineret™, Swedish Orphan Biovitrum), would quench patients ADHF. Methods: randomized 30 ADHF, reduced left ventricular ejection fraction (LVEF&lt;40%), elevated C reactive protein (CRP) levels (≥5...

10.1161/circ.132.suppl_3.16959 article EN Circulation 2015-11-10

Abstract Cardiac resynchronization therapy device implantation is complicated by a significant rate of failure to place left ventricular lead via the coronary sinus. The present case describes one such ironically leading resynchronization. patient's QRS narrowing subsequent postimplant atrial pacing alone suggests that bradycardia‐dependent phase 4 block was indirect but exclusive cause intraventricular conduction delay. Thus, should be considered when at faster resolves wide interval.

10.1111/pace.13437 article EN Pacing and Clinical Electrophysiology 2018-06-29

We thank Drs Pachon for their interest in our recent report. Collaboration is critical novel procedures. The comment “atropine at CNA beginning was the villain” unclear; there no “rapid innervation.” Rather, we objectively demonstrated persistent denervation. Fundamentally, an interesting observation of report not recurrence itself, but nature recurrence. Heart rate (HR) and HR variability slowly normalizing over extended time course does suggest a simple procedural failure, perhaps that...

10.1016/j.hrcr.2022.05.007 article EN cc-by HeartRhythm Case Reports 2022-05-12

Introduction: Some patients suffer recurrent syncope following cardioneuroablation (CNA) for vasovagal (VVS), yet no cases of repeat CNA have been described in detail. Methods and Results: Our present patient suffered a recurrence seven months successful wished CNA. Pre-procedurally, she lacked an atropine response. During CNA, high-frequency stimulation (HFS) at ganglionated plexi (GP) would not trigger cardioinhibitory events. Ablation was delivered based on anatomy fractionation mapping,...

10.22541/au.165450244.47599739/v1 preprint EN Authorea (Authorea) 2022-06-06
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