Nicholas Sangala

ORCID: 0000-0003-3997-2512
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About
Contact & Profiles
Research Areas
  • Dialysis and Renal Disease Management
  • Muscle and Compartmental Disorders
  • Hemodynamic Monitoring and Therapy
  • Blood Pressure and Hypertension Studies
  • Palliative Care and End-of-Life Issues
  • Grief, Bereavement, and Mental Health
  • Non-Invasive Vital Sign Monitoring
  • Dysphagia Assessment and Management
  • Electrolyte and hormonal disorders
  • Health Systems, Economic Evaluations, Quality of Life
  • Financial Literacy, Pension, Retirement Analysis
  • Nutrition and Health in Aging
  • Global Health Care Issues
  • Renal Transplantation Outcomes and Treatments
  • Family Caregiving in Mental Illness
  • Polyomavirus and related diseases
  • Healthcare Policy and Management
  • Diabetes Management and Education
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Vasculitis and related conditions
  • Family and Patient Care in Intensive Care Units
  • Mobile Health and mHealth Applications
  • Cardiovascular Syncope and Autonomic Disorders
  • Artificial Intelligence in Healthcare
  • Digital Mental Health Interventions

Portsmouth Hospitals NHS Trust
2021-2024

Kidney Centre
2017-2024

Royal Sussex County Hospital
2015-2019

Queen Alexandra Hospital
2015-2017

St. Thomas Hospital
2009

St Thomas' Hospital
2009

King's College - North Carolina
2009

Early in the coronavirus-2019 (COVID-19) containment strategy, people with end-stage renal disease (ESRD) were identified as extremely clinically vulnerable and subsequently asked to ‘shield’ at home where possible. The aim of this study was investigate how these restrictions transition an increased reliance on telemedicine within clinical care living kidney impacted physical activity (PA), wellbeing quality life (QoL) adults dialysing (HHD) or receiving in-centre haemodialysis (ICHD) UK....

10.3390/ijerph18063144 article EN International Journal of Environmental Research and Public Health 2021-03-18

When people with chronic kidney disease reach failure, renal replacement therapy is usually required to improve symptoms and maintain life. Although in-centre haemodialysis most commonly used for this purpose, other forms of dialysis are available, including home peritoneal dialysis.We aimed explore the experiences adults living who were either approaching need or had reached failure receiving a form dialysis. In particular, we explored how different affect their quality life, wellbeing,...

10.1111/jorc.12416 article EN cc-by Journal of Renal Care 2022-02-28

My Kidneys & Me (MK&M), a digital health intervention delivering specialist and lifestyle education for people with CKD, was developed its effects tested (SMILE-K trial, ISRCTN18314195, 18/12/2020). 420 adult patients CKD stages 3-4 were recruited randomised 2:1 to (MK&M) (n = 280) or control 140) groups. Outcomes, including Patient Activation Measure (PAM-13), collected at baseline 20 weeks. Complete case (CC) per-protocol (PP) analyses conducted. 210 (75%) participants used MK&M more than...

10.1038/s41746-024-01296-1 article EN cc-by npj Digital Medicine 2024-11-12

People with end-stage kidney disease (ESKD) often exhibit impaired cardiac structure and function, which may contribute to poor exercise capacity. This study used multimodal testing investigate the central peripheral mechanisms of limitation in adults ESKD, also comparing in-centre hemodialysis (ICHD) home (HHD). Seventeen (55.5 ± 14.5 years; n = 14 male; 12 HHD) participated. Resting examinations, followed by submaximal cycling cardiopulmonary (CPET) functional testing, revealed structural...

10.14814/phy2.70050 article EN cc-by Physiological Reports 2024-09-01

Although kidney transplantation is the best treatment for failure, scarce research has examined its effects on physical activity, function and quality of life.To investigate experiences a group adults living with advanced disease focusing life, activity to see how findings differ in transplant recipients.Individual semi-structured interviews were conducted (n = 10; 70.5 ± 8.9 years) who had received 50.7 11.5 years; age: 42.7 20.9 months). Interviews transcribed verbatim, thematically...

10.1111/jorc.12443 article EN cc-by-nc Journal of Renal Care 2022-10-17

SUMMARY Background Intra‐dialytic hypotension (IDH) remains a frequent but serious complication of haemodialysis. Methods We performed retrospective observational analysis our prevalent dialysis population extracting data from an online database. Results Four hundred and thirty‐two patients underwent 21 consecutive outpatient sessions during the study period: Of 9,072 studied, 438 were complicated by episodes IDH (4.8%). 266/432 asymptomatic whilst 166/432 experienced at least one episode...

10.1111/jorc.12203 article EN Journal of Renal Care 2017-05-04

Renal infiltration with leukaemic cells is a common finding in patients suffering chronic lymphocytic leukaemia (CLL) but rarely does it lead to significant renal dysfunction. Similarly, BK nephropathy recognized cause of graft failure transplant recipients causes disease native kidneys. In the few reports where kidney has led impairment, pathological process causing dysfunction not identified on biopsy. these cases, unclear whether polyomavirus (BKV) been excluded. We describe case dual...

10.1093/ndtplus/sfq193 article EN cc-by-nc Clinical Kidney Journal 2010-12-02

Background Although frequent low-flow, low-volume haemodialysis using the NxStage System One is now well-established as an option for home therapy of end-stage chronic kidney disease, its ability to deliver adequate dialysis in people with high BMI remains questionable. This doubt may lead obese individuals being denied potential benefits this modality. To establish if justified, we compared adequacy two groups individuals; one receiving standard thrice-weekly in-centre and other at One....

10.7759/cureus.35054 article EN Cureus 2023-02-16

Families of patients consider timely, clear, and compassionate communication as an indicator quality care in the ICU(1). Good with family members dying on ICU can reduce burden bereavement, whilst better throughout admission improve experience general (2). Nursing staff are major contributors to through their frequent interactions at bedside. also provide support over telephone.

10.1186/2197-425x-3-s1-a713 article EN cc-by Intensive Care Medicine Experimental 2015-10-01

ABSTRACT Background Treatment of end-stage renal disease (ESRD) is necessary to maintain life. However, it can cause physiological, psychosocial, and cognitive impairments, which may impact physical activity (PA) sleep, although there insufficient device-based data elucidate such impacts. Methods PA, sedentary time (SED), sleep were measured over 7 consecutive days in 12 adults with ESRD (9 dialyzing at home, 3 center) using wrist-worn accelerometers. Validated raw acceleration thresholds...

10.31189/2165-6193-11.2.38 article EN Journal of Clinical Exercise Physiology 2022-05-19

10.1016/j.bja.2019.05.021 article EN publisher-specific-oa British Journal of Anaesthesia 2019-07-03

Patients undergoing haemodialysis (HD) are exposed to other morbidities due their treatment, whether at home or in a clinical setting. Intradialytic hypotension (IDH), the most serious of adverse effects, is associated with increased mortality. Early intervention such dangerous event highly desirable for prevention, yet no tool management and decision making IDH has been available until now. This study aimed investigate scope machine learning (ML) techniques predicting by analysing various...

10.1016/j.ekir.2022.01.673 article EN Kidney International Reports 2022-02-01
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