A5091697778- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Skin and Cellular Biology Research
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Pancreatitis Pathology and Treatment
- Immune cells in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Liver Disease and Transplantation
- Extracellular vesicles in disease
- Liver physiology and pathology
- Galectins and Cancer Biology
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Dietary Effects on Health
- Chemokine receptors and signaling
- Kruppel-like factors research
- MicroRNA in disease regulation
German Cancer Research Center
2021-2025
University Medical Centre Mannheim
2019-2025
Heidelberg University
2019-2025
University Hospital Heidelberg
2019-2025
University of Tübingen
2025
DKFZ-ZMBH Alliance
2023
National Center for Tumor Diseases
2023
Medizinische Fakultät Mannheim
2021
Allameh Tabataba'i University
2020
University Hospital Carl Gustav Carus
2016-2019
Hepatocellular carcinoma (HCC) is increasingly associated with non-alcoholic steatohepatitis (NASH). HCC immunotherapy offers great promise; however, recent data suggests NASH-HCC may be less sensitive to conventional immune checkpoint inhibition (ICI). We hypothesised that targeting neutrophils using a CXCR2 small molecule inhibitor sensitise ICI therapy. Neutrophil infiltration was characterised in human and mouse models of HCC. Late-stage intervention anti-PD1 and/or performed murine...
The progression of non-alcoholic steatohepatitis (NASH) to fibrosis and hepatocellular carcinoma (HCC) is aggravated by auto-aggressive T cells. gut-liver axis contributes NASH, but the mechanisms involved consequences for NASH-induced liver cancer remain unknown. We investigated role gastrointestinal B cells in development HCC.
The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic steatohepatitis (NASH) its transition to hepatocellular carcinoma (HCC) are unknown. Here, we identified that an IF 5:2 regimen prevents NASH development as well ameliorates established fibrosis without affecting total calorie intake. Furthermore, the blunted NASH-HCC when applied therapeutically. timing, length, number cycles type diet were critical parameters determining benefits fasting. Combined proteome,...
Abstract Cell fate plasticity enables development, yet unlocked is a cancer hallmark. While transcription master regulators induce lineage-specific genes to restrict plasticity, it remains unclear whether actively suppressed by repressors. Here we computationally predict so-called safeguard repressors for 18 cell types that block phenotypic lifelong. We validated hepatocyte-specific candidates using reprogramming, revealing prospero homeobox protein 1 (PROX1) enhanced hepatocyte identity...
The aim of this study was to test the hypothesis that intraoperative frozen section (FS) and re-resection results achieve R0 status are associated with different long-term outcomes in pancreatic cancer patients.Recent data have challenged survival benefit additional resection patients case positive FS clear pathological (PS).Patients who underwent surgery for exocrine malignancy curative intent were identified from a prospective database. Data stratified by margin (group I: FS-R0 → PS-R0;...
Despite evidence-based guidelines, exocrine pancreatic insufficiency is frequently underdiagnosed and undertreated in patients with chronic pancreatitis. Therefore, the aim of this study to provide insight into current opinion clinical decision-making international pancreatologists regarding management insufficiency. An online survey case vignette was sent experts pancreatitis members various associations: EPC, E-AHPBA DPSG. Experts were selected based on publication record from past 5...
Posthepatectomy liver failure (PHLF) is the most fatal complication following resection, particularly, in patients with comorbidities. This study aimed to assess impact of long-term medication on PHLF incidence after open resections. A retrospective analysis 682 who underwent elective hepatectomies between 2008 and 2015 at two academic centers was performed. Preoperative, intraoperative, postoperative data were collected, including medication. Risk factors for development other complications...
Objectives: The aim of this study was to assess intraoperative changes hepatic macrohemodynamics and their association with ascites posthepatectomy liver failure (PHLF) after major hepatectomy. Summary Background Data: Large-scale PHLF remain clinical challenges No has concomitantly evaluated arterial venous in patients undergoing resection. Methods: Portal pressure (PVP), portal flow (PVF), (HAF) were measured intraoperatively pre- postresection 67 consecutive hepatectomy (ie, resection ≥3...
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays critical role in onset progression. Here we show plectin, major cytoskeletal crosslinker protein, crucial mechanical homeostasis mechanosensitive oncogenic signaling drives hepatocarcinogenesis. Our expression analyses revealed elevated plectin levels liver tumors,...
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays critical role in onset progression. Here, we show plectin, major cytoskeletal crosslinker protein, crucial mechanical homeostasis mechanosensitive oncogenic signaling drives hepatocarcinogenesis. Our expression analyses revealed elevated plectin levels liver tumors,...
Red meat consumption is considered a risk factor for colorectal cancer (CRC) development and stimulated isolation of plasmid-like DNA molecules from bovine serum milk, termed milk factors (BMMFs). BMMFs encode conserved replication protein (Rep). Increased populations Rep-expressing macrophages have been identified in the peritumor CRC patients pre-cancerous tissues when compared to healthy individuals. This supports concept that increase by indirect carcinogenesis, upon induction chronic...
Importance Postpancreatectomy hemorrhage (PPH) due to postoperative pancreatic fistula (POPF) is a life-threatening complication after pancreatoduodenectomy. However, there no prediction tool for early identification of patients at high risk late PPH. Objective To develop and validate model Design, Setting, Participants This retrospective prognostic study included consecutive with clinically relevant POPF who underwent pancreatoduodenectomy from January 1, 2009, May 20, 2023, the University...
The application of reverse osmosis (RO) to recover nutrients from biomass leachate, with special reference permeate flux behavior during the filtration is investigated in this paper through a comprehensive laboratory and modeling approach. Various sources biomass, including soybean straw, switchgrass, miscanthus, were industrially leached using distilled water agitation extraction experiments. leachates filtered RO flat sheet membrane module water. On basis inductively coupled plasma (ICP)...
Abstract Background Resection of centrally located liver lesions remains a technically demanding procedure. To date, there are limited data on the effectiveness and safety minimally invasive mesohepatectomy for benign malignant lesions. It was therefore objective this study to evaluate perioperative outcomes tumors at tertiary care hospital. Methods Consecutive patients who underwent anatomic using Glissonean pedicle approach from April 2018 November 2021 were identified prospective...
// Nuh N. Rahbari 1, * , Sebastian Schölch Ulrich Bork 1 Christoph Kahlert Martin Schneider 2 Mohammad Markus W. Büchler Jürgen Weitz and Reissfelder Department of Gastrointestinal, Thoracic Vascular Surgery, Technische Universität Dresden, Germany General, Visceral Transplant University Heidelberg, These authors have contributed equally to this work Correspondence to: Rahbari, email: nuh.rahbari@uniklinikum-dresden.de Keywords: circulating endothelial cells, CEC, tumor CTC, colorectal...
Bone morphogenetic protein (BMP)-9, a member of the TGFβ-family cytokines, is believed to be mainly produced in liver. The serum levels BMP-9 were reported reduced newly diagnosed diabetic patients and overexpression ameliorated steatosis high fat diet-induced obesity mouse model. Furthermore, injection mice enhanced expression fibroblast growth factor (FGF)21. However, whether also regulates related FGF19 not clear. Because both FGF21 19 described protect liver from steatosis, we have...
Exosomes are nano-sized membranous vesicles of endosomal origin that carry nucleic acids, lipids and proteins. The cargo exosomes is cell specific the release these uptake by an acceptor seen as a vital element cell-cell communication. Here, we sought to investigate diagnostic prognostic value expression glypican 3 (GPC3) on primary gastro-esophageal adenocarcinoma (GEA) tissue (tGPC3) corresponding serum (eGPC3). Circulating were extracted from samples 49 patients with GEA 56 controls....