A5010748930- Radiopharmaceutical Chemistry and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radioactive element chemistry and processing
- Lanthanide and Transition Metal Complexes
- Metal complexes synthesis and properties
- Nanoparticle-Based Drug Delivery
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Medical Imaging Techniques and Applications
- Dendrimers and Hyperbranched Polymers
- Adenosine and Purinergic Signaling
- Inorganic Chemistry and Materials
- Crystallography and molecular interactions
- Peptidase Inhibition and Analysis
- Polyoxometalates: Synthesis and Applications
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Mass Spectrometry Techniques and Applications
- Supramolecular Chemistry and Complexes
- Extraction and Separation Processes
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Characterization
- Nanocluster Synthesis and Applications
- Analytical chemistry methods development
Institute of Cancer Research
2014-2025
Helmholtz-Zentrum Dresden-Rossendorf
2016-2025
Technische Universität Dresden
1993-2019
Monash University
2008-2014
University of Bologna
2013-2014
Heidelberg University
1998-2014
Federal Institute For Materials Research and Testing
2009
Ollscoil na Gaillimhe – University of Galway
2007-2009
Nikolaev Institute of Inorganic Chemistry
2007
Johannes Gutenberg University Mainz
2000
Abstract Polyoxometalates (POMs) are inorganic cluster compounds that have been shown to possess a number of pharmacological properties, including antidiabetic, antibacterial, antiprotozoal, antiviral and anticancer activities. Their molecular mechanism action is largely unknown. However, several studies indicate many their activities may be due the inhibition enzymes, in particular, those enzymes accessible from extracellular space do not require penetration cell membranes. In this review,...
The preparation and use of bispidine derivatives (3,7-diazabicyclo[3.3.1]nonane) as chelate ligands for radioactive copper isotopes diagnosis (64Cu) or therapy (67Cu) are reported. Starting from the hexadentate bispidine-based bis(amine)tetrakis(pyridine) ligand 1 with a keto two ester substituents, corresponding mono-ol 2 dicarboxylic acid 3 5 have been synthesized. A range techniques, including single-crystal X-ray structure analysis, UV/vis spectroscopy, cyclic voltammetry, thin-layer-...
Ultrasmall clearable nanoparticles possess enormous potential as cancer imaging agents.
For their application in the area of diagnosis and therapy, single-domain antibodies (sdAbs) offer multiple advantages over conventional fragments thereof terms size, stability, solubility, immunogenicity, production costs as well tumor uptake blood clearance. Thus, sdAbs have been identified valuable next-generation targeting moieties for molecular imaging drug delivery past years. Since these probes are much less complex than antibody fragments, bacterial expression represents a facile...
Nanoparticles functionalized with single domain antibodies are shown to specifically target the EGF receptor in vitro. We investigate effects on uptake and specificity when increasing environmental serum toward more vivo "realistic" concentrations.
Abstract From cultures of Yersinia enterocolitica H1852, an iron‐complexing and iron‐transporting compound named yersiniabactin was isolated. The structure the siderophore determined by a variety spectroscopic methods, including 2D NMR experiments on metal‐free ligand as well its gallium complex. ligand, derivatives, iron complexes were examined high‐resolution FAB‐MS, API‐MS, API‐MS/MS GC‐MS. novel contains benzene thiazolidine ring, two thiazoline rings (Figure 1). Its stereochemistry is...
A novel molecular host 5 for amino acid zwitterions is described. The covalent connection of a chiral bicyclic guanidinium salt as an anchor function the carboxylate and triaza-crown ether ammonium binding moiety in combination with strongly hydrophobic silyl serves to complex transfer acids from water into dichloromethane unprecedented efficiency. Quantitation extraction process by radiometry revealed clean 1:1 stoichiometry gives evidence zwitterion species undergoing phase transfer. Even...
We report a nonadentate bispidine (3,7-diazabicyclo[3.3.1]nonane) that unveils the potential to bind theranostically relevant radionuclides, including indium-111, lutetium-177, and actinium-225 under mild labeling conditions. This radiopharmaceutical candidate allows simultaneous application of imaging treatment (radionuclide theranostics) without changing type bioconjugate; is, it strong binding an therapeutic radionuclide by same chelator. Since sophisticated coordination chemistry is...
Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies. Yet, their effectiveness is limited when tackling solid tumors, where immune cell infiltration and immunosuppressive tumor microenvironments (TME) major hurdles. Fibroblast activation protein (FAP) highly expressed on cancer-associated fibroblasts (CAFs) various cells, playing an important role growth immunosuppression. Aiming to modulate the TME with...
Octadentate and specifically nonadentate ligands with a bispidine scaffold (3,7-diazabicyclo[3.3.1]nonane) are known to be efficiently coordinated range of metal ions interest in radiopharmaceutical chemistry lead exceedingly stable inert complexes. Nonadentate L2 (with tridentate bipyridine acetate appended N3 picolinate at N7) has been shown before an ideal chelator for 111In3+, 177Lu3+, 225Ac3+, nuclides diagnosis therapy, proof-of-principle study SSTR2-specific octreotate potential...
A new ligand derivative of 1,4,7-triazacyclononane (TACN), 2-[4,7-bis(2-pyridylmethyl)-1,4,7-triazacyclononan-1-yl]acetic acid ( 6), has been synthesized and its complexation behavior toward Cu2+ ions investigated. The 6 characterized by spectroscopic methods, a molecular structure corresponding Cu(II) complex elucidated single-crystal X-ray analysis. suitability for conjugation to peptide substrates shown amide coupling the stabilized bombesin (BN), beta Ala-beta Ala-[Cha13, Nle14]BN(7-14),...
The hexarhenium anionic cluster complex with terminal formate ligands [Re6S8(HCOO)6]4− was obtained by the room-temperature reaction between [Re6S8(OH)6]4− and formic acid in an aqueous solution. crystallized as a potassium or cesium salt characterized X-ray single-crystal diffraction elemental analyses, IR, 1H NMR, UV/vis, luminescence spectroscopies. In particular, emission quantum yield of Re6 anion solid phase determined for first time. electronic structures were also elucidated DFT calculations.
Pentadentate bispidine ligands (3,7-diazabicyclo[3.3.1]nonanes) are optimized for maximum complex stability and facile functionalization with respect to their coupling biological vector molecules and/or fluorescence markers PET (positron emission tomography) multimodal imaging (i.e., optical imaging). The pentadentate ligand two tertiary amine donors, p-methoxy substituted pyridines, one unsubsituted pyridine group is shown best fulfill important conditions applications, i.e., fast...