A5017626763- Ion Channels and Receptors
- European history and politics
- Medical History and Research
- Cancer Immunotherapy and Biomarkers
- Cholinesterase and Neurodegenerative Diseases
- Genomics, phytochemicals, and oxidative stress
- Phytochemicals and Antioxidant Activities
- Historical Studies on Reproduction, Gender, Health, and Societal Changes
- Urinary Bladder and Prostate Research
- Magnesium in Health and Disease
- Herbal Medicine Research Studies
- Adenosine and Purinergic Signaling
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- German History and Society
- Immune Cell Function and Interaction
VIB-KU Leuven Center for Brain & Disease Research
2023-2024
KU Leuven
2023
Warsaw University of Life Sciences
2020
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2020
Many individuals with cancer are resistant to immunotherapies. Here, we identify the gene encoding pyrimidine salvage pathway enzyme cytidine deaminase (CDA) among top upregulated metabolic genes in several immunotherapy-resistant tumors. We show that CDA cells contributes uridine diphosphate (UDP) pool. Extracellular UDP hijacks immunosuppressive tumor-associated macrophages (TAMs) through its receptor P2Y
Naringenin, a flavanone obtained from citrus fruits and present in many traditional Chinese herbal medicines, has been shown to have various beneficial effects on cells both vitro vivo. Although the antioxidant activity of naringenin long believed be crucial for its cells, mitochondrial pathways (including ion channels) are emerging as potential targets specific pharmacological action cardioprotective strategies. In study, we describe interactions between large-conductance calcium-regulated...
Antagonists of TRPV1 that inhibit all activation modes cause hyperthermia, hampering their medical use as novel analgesics. antagonists do not (fully) responses to low pH but it remains incompletely understood how such affect channel gating. We tested the hypothesis pH-sparing act in a modality-selective manner on TRPV1, differentially affecting by protons and capsaicin.Using whole-cell patch-clamp calcium imaging measure activity cells expressing wild type human or pH-insensitive mutant...
and purpose: Phenazopyridine (PAP) is an over-the-counter drug widely used to provide symptomatic relief of bladder pain in conditions such as cystitis or syndrome (BPS). Whereas the analgesic effect PAP has been attributed a local on mucosa lower urinary tract (LUT), molecular targets remain unknown. We investigated pain-related Transient Receptor Potential (TRP) channels expressed sensory neurons that innervate wall.The effects relevant TRP (TRPV1, TRPA1, TRPM8, TRPM3) HEK293 CHO cells was...