A5103078211- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- AI in cancer detection
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related gene regulation
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Adenosine and Purinergic Signaling
- Cell death mechanisms and regulation
- Grit, Self-Efficacy, and Motivation
- Dietary Effects on Health
- Lung Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Kruppel-like factors research
- Immune Cell Function and Interaction
- Gut microbiota and health
- Prenatal Screening and Diagnostics
- Protein Degradation and Inhibitors
- Single-cell and spatial transcriptomics
Shanghai Jiao Tong University
2020-2025
Shanghai Cancer Institute
2019-2025
Renji Hospital
2019-2025
State Key Laboratory of Oncogene and Related Genes
2019-2023
East China Normal University
2022
Xiangya Hospital Central South University
2019
Central South University
2018-2019
Guangdong General Hospital
2018
Guangdong Academy of Medical Sciences
2018
The current pathological and molecular classification of pancreatic ductal adenocarcinoma (PDAC) provides limited guidance for treatment options, especially immunotherapy. Cancer-associated fibroblasts (CAFs) are major players desmoplastic stroma in PDAC, modulating tumor progression therapeutic response. Using single-cell RNA sequencing, we explored the intertumoral heterogeneity among PDAC patients with different degrees desmoplasia. We found substantial CAFs, cancer cells, immune cells...
Background and Aims: The liver has the unique ability of regeneration, which is extremely important for restoring homeostasis after injury. Although clinical observations have revealed an association between psychological stress liver, whether a causal influence on regeneration remains markedly less defined. Approach Results: Rearing rodents in enriched environment (EE) can induce eustress or positive stress. Herein, EE-induced was found to significantly enhance partial hepatectomy carbon...
Chondroitin polymerizing factor (CHPF) is an important glycosyltransferase involved in the biosynthesis of chondroitin sulfate. However, relationship between CHPF and gastric cancer has not been fully investigated. expression tissues was detected by immunohistochemistry correlated with patient prognosis. Cultured cells human epithelial cell line GES1 were used to investigate effects shCHPF shE2F1 on development progression MTT, western blotting, flow cytometry analysis apoptosis, colony...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with limited effective treatment options. Emerging evidence links enriched environment (EE)-induced eustress to PDAC inhibition. However, the underlying mechanisms remain unclear. In this study, we explored role of gut microbiota in PDAC-suppressive effects EE. We demonstrated that depletion antibiotics abolished EE-induced tumor suppression, while fecal transplantation (FMT) from EE mice significantly inhibited growth...
The ubiquitin-proteasome system (UPS) is a regulated mechanism of intracellular protein degradation and turnover, its dysfunction associated with various diseases including cancer. UBR5, an E3 ubiquitin ligase, emerging as important regulator the UPS in cancers, but role pancreatic cancer poorly understood. Here, we show that UBR5 significantly upregulated tissues. High expression correlated increased lymph node metastasis poor survival patients. loss-of-function gain-of-function studies...
Purpose: Ubiquitin-conjugating enzyme E2S (UBE2S) is important for the development and progression of several types cancer. However, neither role UBE2S in pancreatic cancer nor its mechanism clear. Methods: We analyzed three GEO datasets to obtain 150 differentially expressed genes (DEGs) between ductal adenocarcinoma (PDAC) non-cancerous samples. Moreover, GSEA mutation analysis were also done UBE2S. The expression PDAC was measured by immunohistochemistry qRT-PCR. Colony formation, scratch...
The bromodomain and extra-terminal domain (BET) family of proteins, especially BRD4 play an important role in epigenetic regulation, are essential for cell survival also promising anticancer targets. This study aims to analyze the effect on growth progression pancreatic cancer novel mechanisms involved.Expression paired adjacent noncancerous tissues from 76 patients was analyzed by western blotting, immunohistochemistry, real time PCR. Its correlation with clinicopathological characteristics...
Evidence has indicated that lysine methyltransferase 2B (KMT2B), a major H3K4 tri-methyltransferase (H3K4me3), contributes to the development of various cancers; however, its role in cervical cancer (CC) is unclear. In this study, increased KMT2B expression was observed human CC specimens and significantly associated with poor prognosis. The condition medium KMT2B-overexpressing cells facilitated angiogenesis vitro. subcutaneous model CC, overexpression promoted tumor growth vascular...
Pancreatic cancer (PC) is one of the most lethal malignancies characterized by a highly immunosuppressive tumor microenvironment (TME). Previously, we have reported that ubiquinol-cytochrome c reductase core protein I (UQCRC1), key component mitochondrial complex III, generally upregulated in PC and produces extracellular ATP (eATP) to promote progression. Here, sought investigate whether oncogenic property UQCRC1 generated through its effects on natural killer (NK) cells TME. We found...
Rationale: Brain metastasis of choriocarcinoma is a highly malignant gestational trophoblastic neoplasia (GTN) and has notoriously poor prognosis. Hemorrhagic lesions may lead to life-threatening conditions also. Treatment brain metastases with hemorrhage in multiple sites very difficult clinical practices. A patient been successfully treated our hospital, which provides as references for this difficulty treating sites. Patient concerns: 28-year-old gravida 2, para 0 was admitted hospital...
Spread through air spaces (STAS) is a distinct invasion pattern in lung cancer, crucial for prognosis assessment and guiding surgical decisions. Histopathology the gold standard STAS detection, yet traditional methods are subjective, time-consuming, prone to misdiagnosis, limiting large-scale applications. We present VERN, an image analysis model utilizing feature-interactive Siamese graph encoder predict from cancer histopathological images. VERN captures spatial topological features with...
e16218 Background: Two studies in ASCO 2018 showed the preliminary efficacy of PD-1 inhibitor and AG as first-line therapy for advanced pancreatic cancer, disease control rate (DCR) was up to 100%. However, a phase 1 study nivolumab plus nab-paclitaxel gemcitabine PDAC, objective response (ORR) only 18%, progression-free survival (PFS)/overall (OS) were 5.5/9.9 months, which quite different from what had been reported before ASCO. All patients received continuous chemotherapy, tolerance...
To investigate the severity of blood steal and hemodynamic profiles in patients with subclavian artery stenosis combined vertebral stenosis.A retrospective analysis was performed transcranial Doppler (TCD) data from (SAS) concomitant unilateral/bilateral (VAS, >50%) or occlusion our institution between February, 2014 July, 2018.Thirty-seven SAS VAS (SAS+VAS) were reviewed for types steal, peak systolic velocities flow affected contralateral artery, findings hyperemia testing.These also 39...
TPS4665 Background: Pancreatic cancer is a malignant tumor with limited therapeutic strategies and poor prognosis. About 60% of the patients have metastasis disease at time diagnosis lose opportunity for surgery. Thus, therapy based on drugs becomes vital part in pancreatic cancer. In 2013, MPACT showed that albumin-bound paclitaxel combined gemcitabine treatment metastatic could increase mOS from 6.6 months to 8.7 (HR = 0.72, 95% CI: 0.62-0.83; P < 0.001). Nowadays, immunosuppressive...