A5102923187- Virus-based gene therapy research
- Obsessive-Compulsive Spectrum Disorders
- CAR-T cell therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Traumatic Brain Injury Research
- CRISPR and Genetic Engineering
- Transcranial Magnetic Stimulation Studies
- Cancer-related molecular mechanisms research
- Functional Brain Connectivity Studies
- Hepatitis C virus research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neural and Behavioral Psychology Studies
- Immune Cell Function and Interaction
- RNA Research and Splicing
- interferon and immune responses
- Hepatitis B Virus Studies
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Immune cells in cancer
- Advanced Neuroimaging Techniques and Applications
- Inflammasome and immune disorders
- Diabetes Management and Research
Xuzhou Medical College
2025
State Key Laboratory of Oncogene and Related Genes
2023-2024
Renji Hospital
2023-2024
Shanghai Jiao Tong University
2021-2024
Shanghai Cancer Institute
2023-2024
Shanghai Mental Health Center
2021-2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Witten/Herdecke University
2017-2022
Capital Medical University
2019-2021
Recent evidence shows that BRAF-activated non-coding RNA (BANCR) acts as a critical role in the proliferation and metastasis malignant melanoma lung cancer; however, little is known about significance of lncRNA BANCR retinoblastoma. The purpose our study to explore retinoblastoma clinical samples cell lines. expression was measured 60 normal retina by using RT-PCR. effects on proliferation, migration, invasion were also explored. In results, overexpressed tissues lines associated with tumor...
Background and Aims: The liver has the unique ability of regeneration, which is extremely important for restoring homeostasis after injury. Although clinical observations have revealed an association between psychological stress liver, whether a causal influence on regeneration remains markedly less defined. Approach Results: Rearing rodents in enriched environment (EE) can induce eustress or positive stress. Herein, EE-induced was found to significantly enhance partial hepatectomy carbon...
ABSTRACT Objective The paraspinal muscles are a crucial component of the spine's extrinsic stabilization system. While impact muscle sarcopenia on patient‐reported outcome measures (PROMs) after lumbar surgery is well known, its effects following percutaneous transforaminal endoscopic discectomy (PTED) have not been investigated. To investigate prognostic value preoperative long‐term PROMs PTED, and to identify independent predictors chronic postoperative low back pain. Methods In this...
Gene therapy represents an attractive alternative to treat hemophilia B. Here we established three hepatocyte-derived cell lines based on Huh7, PLC/PRF/5, and Hep3B cells stably carrying a mutated canine FIX (cFIXmut) transgene containing single point mutation in the catalytic domain. Based these vitro models resembling commonly used large animal model, tetracycline-controlled transcriptional activator (Tet-on)-inducible CRISPR/Cas9 system optimized donor were correct cFIX gene through...
Although the functional connectivity of patients with disorders consciousness (DOC) has been widely examined, less is known about brain white matter connectivity. The aim this study was to explore structural network alterations for diagnosis and prognosis chronic DOC. Eleven DOC 11 sex- age-matched controls were included in study. Participants underwent diffusion magnetic resonance imaging (MRI) T1-weighted MRI at 7 tesla (7 T). Graph-theoretical analysis network-based statistics used...
Abstract The mechanisms underlying the development and progression of colon cancer are not fully understood. Herein, Src kinase associated phosphoprotein 1 (SKAP1), an immune cell adaptor, is identified as a novel cancer‐related gene. SKAP1 expression significantly increased in cells. High levels independently predictive poor survival patients with cancer. Notably, cells exerted significant tumor‐promoting effect vivo rather than vitro. Screening tumor‐infiltrating revealed involvement...
To develop adenoviral cell- or tissue-specific gene delivery, understanding of the infection mechanisms adenoviruses is crucial. Several attachment proteins such as CD46, CAR and sialic acid have been identified studied. However, most receptor studies were performed on non-human cells. Combining our reporter gene-tagged adenovirus library with an in vitro human knockout model, we a systematic analysis usage comparing different side-by-side. The CRISPR/Cas9 system was used to CD46 lung...
Summary. A recent genome‐wide association study discovered that two polymorphisms, interferon (IFN) alpha receptor 2 (IFNAR‐2) F8S and interleukin 10 (IL10RB) K47E, were associated with susceptibility to hepatitis B virus (HBV) infection in Africa. Here, we reevaluate the effects of polymorphisms on HBV Chinese Han population, extended look at their IFN response chronic (CHB). We included 341 patients CHB unrelated controls presenting asymptotic self‐limited infection, who well matched age...
Objective: Previous studies suggest that abnormal brain structure and function may be neuroimaging endophenotypes of obsessive-compulsive disorder (OCD). Comparing the intrinsic activity OCD patients their unaffected siblings will help to further understand susceptibility to, pathological mechanisms of, OCD. We used a case-control study design aiming establish whether regional homogeneity (ReHo) found in also exists siblings. Method: Fifteen unmedicated patients, 15 siblings, 30 healthy...
Oncolytic adenoviruses (Ads) are promising tools for cancer therapeutics. However, most Ad-based therapies utilize Ad type 5 (Ad5), which displays unsatisfying efficiency in clinical trials, partly due to the low expression levels of its primary coxsackievirus and adenovirus receptor (CAR) on tumor cells. Since efficacy virotherapy strongly relies efficient transduction targeted cells, initial screening a broad range viral agents identify effective vehicles is essential. Using novel library...
Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in various types of tumors and functions as an oncogene; it could also be a potential target tumor therapy. Meanwhile, the high mortality pancreatic adenocarcinoma (PAAD) largely depends on limited effectiveness Based promising PTTG1 cancer treatment, we explored influence treatment PAAD this study. The Cancer Genome Atlas Program (TCGA) data showed that higher expression was associated with clinical stages worse prognosis cancer....
The objective of this study was to find potential biomarkers for predicting sustained virologic responses interferon-α (IFN-α) treatment in chronic hepatitis B (CHB) patients. A total 101 CHB patients were treated with pegylated IFN-α2a 48 weeks and followed up 24 weeks, including 34 IFN responders (IFN-Rs) 67 nonresponders (IFN-NRs). After peripheral blood mononuclear cells (PBMCs) Epstein-Barr virus-transferred (EBV-B) cell lines different concentrations IFN-α vitro, activated...
Methods for customizing and improving virus vector tropism are limited. In this study, we introduce a microRNA (miRNA)-regulated molecular method to enhance transduction without genome alteration. Based on the importance of adenovirus (Ad) vectors cancer gene treatment, exemplified technology an Ad type 5 (Ad5) temporally carrying knob from Ad37. We constructed producer cell line stably expressing fused Ad5/37 chimeric fiber comprising Ad5 shaft-tail Ad37 miRNA inhibiting expression...
<h3>Background:</h3> Cognitive behavioural therapy (CBT) is considered an effective first-line treatment for obsessive–compulsive disorder (OCD). However, the neural basis of CBT OCD has not yet been elucidated. The role amygdala in and its functional coupling with cerebral cortex have received increasing attention, may provide new understanding OCD. <h3>Methods:</h3> We acquired baseline resting-state MRI (fMRI) scans from 45 unmedicated patients 40 healthy controls; we then another wave...
Lenvatinib is a potent first-line therapy for patients with hepatocellular carcinoma (HCC), but it also increased the number of neutrophils in HCC tumor microenvironment. CitH3, MPO-DNA, elastase and MPO activity were measured assessing neutrophil extracellular traps (NETs) vivo vitro. Cell cuproptosis was assessed by measurement copper content, FDX1, pyruvate. The functions lenvatinib, DNase I, interleukin 33 (IL33) neutralizing antibody GPX4 growth explored mice. induced NETs...
Determining the early changes of brain structure that occur from vegetative state/unresponsive wakefulness syndrome (VS/UWS) to a minimally conscious state (MCS) is important for developing our understanding processes underlying disorders consciousness (DOC), particularly during spontaneous recovery severe damage.This study used multi-modal neuroimaging approach investigate structural VS/UWS MCS.The Coma Recovery Scale-Revised (CRS-R) score, 24-h electroencephalography (EEG), and ultra-high...