A5101560694- Peptidase Inhibition and Analysis
- Pregnancy and preeclampsia studies
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Advanced Fiber Laser Technologies
- Adipose Tissue and Metabolism
- Neurofibromatosis and Schwannoma Cases
- Advanced Fiber Optic Sensors
- Supramolecular Chemistry and Complexes
- Peroxisome Proliferator-Activated Receptors
- Hippo pathway signaling and YAP/TAZ
- Photonic Crystal and Fiber Optics
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Biliary and Gastrointestinal Fistulas
- Medical Image Segmentation Techniques
- PI3K/AKT/mTOR signaling in cancer
- Protein Degradation and Inhibitors
- Immune cells in cancer
- Immune Cell Function and Interaction
- Medical Imaging and Analysis
- Nanoplatforms for cancer theranostics
- Gallbladder and Bile Duct Disorders
- Medical Imaging Techniques and Applications
- Pediatric Hepatobiliary Diseases and Treatments
Xi'an Institute of Optics and Precision Mechanics
2024-2025
University of Chinese Academy of Sciences
2024-2025
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Tianjin Medical University
2005-2023
First Affiliated Hospital of Zhengzhou University
2023
Baogang Group (China)
2022
Georgia State University
2017-2021
Beijing University of Chinese Medicine
2021
Shanghai Veterinary Research Institute
2021
Abstract Glioblastoma is an aggressive tumor that associated with distinctive infiltrating microglia/macrophages populations. Previous studies demonstrated chlorogenic acid (5-caffeoylquinic acid, CHA), a phenolic compound low molecular weight, has anti-tumor effect in multiple malignant tumors. In the present study, we focused on macrophage polarization to investigate mechanisms behind anti-glioma response of CHA vitro and vivo . We found treatment increased expression M1 markers induced by...
Abstract In many types of cancer, tumor cells prefer to use glycolysis as a major energy acquisition method. Here, we found that the 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/computed (CT)-based markers were positively associated with expression programmed cell death ligand 1 (PD-L1), pyruvate kinase M2 (PKM2), both which indicate poor prognosis in patients pancreatic ductal adenocarcinoma (PDAC). However, regulatory mechanism PD-L1 remains elusive. this study,...
It is increasingly recognized that activation of beige adipocyte thermogenesis by pharmacological or genetic approaches increases energy expenditure and alleviates obesity. Sympathetic nervous system (SNS) directly innervating brown adipose tissue (BAT) white (WAT) plays a key role in promoting nonshivering thermogenesis. However, direct evidence supports the importance SNS innervation for formation still lacking, significance protection body temperature during cold challenge not clear. Here...
G9a has been reported to highly express in bladder transitional cell carcinoma (TCC) and inhibition significantly attenuates proliferation, but the underlying mechanism is not fully understood. The present study aimed at examining potential role of autophagy anti-proliferation effect on TCC T24 UMUC-3 lines vitro. We found that both pharmaceutical genetical attenuated proliferation by MTT assay, Brdu incorporation assay colony formation assay. induced like morphology as determined...
Abstract Aim JQ1, a BET bromodomain inhibitor, is promising therapeutic approach for bladder cancer (BC). Our study aimed to determine whether autophagy induced by JQ1 and its potential role toward proliferation in BC. Methods Cell was determined methylthiazolyldiphenyl‐tetrazolium bromide (MTT) assay, cell counting colony formation assay. Autophagosomes autolysosomes were observed transmission electron microscopy mRFP‐EGFP‐LC3 fluorescence 3‐MA, BAFA1, NH 4 Cl, siATG5 used inhibit...
Krüppel-like factor 5 (KLF5) promotes cell proliferation of bladder cancer. However, whether KLF5 regulates other processes in cancer is not clear. We found that increases migration and lamellipodia formation, expression FYN phosphorylation FAK cells. In addition, transcription through binding to its promoter. overexpression rescues formation reduced by knockdown. Furthermore, the KLF5/FYN/p-FAK axis necessary for lysophosphatidic acid (LPA) promote migration. Our findings indicate both are...
Abstract Brown adipocytes share the same developmental origin with skeletal muscle. Here we find that a brown adipocyte-to-myocyte remodeling also exists in mature adipocytes, and is induced by prolonged high fat diet (HFD) feeding, leading to dysfunction. This process regulated interaction of epigenetic pathways involving histone DNA methylation. In demethylase UTX maintains persistent demethylation repressive mark H3K27me3 at Prdm16 promoter, expression. PRDM16 then recruits...
Curcumin has frequently been used as a therapeutic agent in the treatment of various types disease and is known to enhance drug sensitivity cells. In present study, combined effect curcumin temsirolimus on apoptosis human renal cell carcinoma (RCC) cells was investigated. Temsirolimus an inhibitor mechanistic target rapamycin signaling pathway first‑line metastatic RCC. It demonstrated that with markedly induced RCC cells, however this not observed following or alone. Co‑treatment led...
We accomplish a compact 150-MHz figure-9 Er:fiber laser through the use of hybrid device wavelength division multiplexer and phase shifter. By combining time-independent rate equation nonlinear Schrödinger equation, evolution intracavity field towards stable mode locking state is presented. further quantify output characteristics laser. Explicitly, 5.8-mW average power, center 1561.2 nm 3-dB spectral bandwidth 29.2 are obtained. More importantly, an integrated root-mean-square relative...
Abstract Nanosystems responsive to tumor‐specific enzymes are considered as a highly attractive approach intracellular drug release for targeted cancer therapy. Mesoporous silica nanoparticles capped with tryptophan‐mediated cucurbit[8]uril complex Fe 3 O 4 minimize the premature leakage while being able deliver payload on demand at target tissue. The supramolecular interaction between tryptophan and is disrupted in presence of indoleamine 2,3‐dioxygenase 1 (IDO1) enzyme (abundant tumor...
Abstract BACKGROUND. Early diagnosis of nasopharyngeal carcinoma (NPC) remains a challenge. Serum protein profiling is promising approach for the classification cancer versus noncancer samples. The objective current study was to assess feasibility mass spectrometry‐based and tree algorithm discriminating between patients with NPC controls. METHODS. samples from controls were analyzed by using surface‐enhanced laser desorption/ionization time‐of‐flight spectrometry (SELDI‐TOF‐MS). divided...
Extracting cardiorespiratory signals from non-invasive and non-contacting sensor arrangements, i.e. magnetic induction sensors, is a challenging task. The respiratory cardiac are mixed on top of large time-varying offset likely to be disturbed by measurement noise. Basic filtering techniques fail extract relevant information for monitoring purposes.We present real-time system based an adaptive Kalman filter approach that separates signal offsets, heart three different channels. It...
Abstract The fabrication, characterization, and therapy efficiency of a noncovalent‐bonded hydrogel network, which is assembled by utilizing cucurbit[7]uril as supramolecular linker to “stick” superparamagnetic γ‐Fe 2 O 3 nanoparticles onto the polymer backbone catechol‐functionalized chitosan are described. unique barrel‐shaped structure not only facilitates host–guest recognition with catechol derivatives, but also forms robust electrostatic interactions between its carbonyl portals in...