A5101608907- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Renal and related cancers
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Bioactive natural compounds
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Ion Transport and Channel Regulation
- Microtubule and mitosis dynamics
- Pancreatic and Hepatic Oncology Research
- Sperm and Testicular Function
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Retinoids in leukemia and cellular processes
- Renal cell carcinoma treatment
- Global Health Care Issues
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Heat shock proteins research
- DNA Repair Mechanisms
- Cell death mechanisms and regulation
- Glutathione Transferases and Polymorphisms
Second Affiliated Hospital of Xi'an Jiaotong University
2011-2025
Xi'an Jiaotong University
2006-2013
Abstract Aim JQ1, a BET bromodomain inhibitor, is promising therapeutic approach for bladder cancer (BC). Our study aimed to determine whether autophagy induced by JQ1 and its potential role toward proliferation in BC. Methods Cell was determined methylthiazolyldiphenyl‐tetrazolium bromide (MTT) assay, cell counting colony formation assay. Autophagosomes autolysosomes were observed transmission electron microscopy mRFP‐EGFP‐LC3 fluorescence 3‐MA, BAFA1, NH 4 Cl, siATG5 used inhibit...
The aquaporins (AQPs), water channel proteins, are known playing a major role in transcellular and transepithelial movement; they also exhibit several properties related to tumor development. aim of the present study is elucidate whether expression AQP5 strong prognostic biomarker for prostate cancer, potential progression cancer cells.AQP5 was measured 60 tissues cells (both PC-3 LNCaP) by immunohistochemistry immunofluorescence assay. gene amplification detected with FISH (fluorescence...
KIFC1 (kinesin family member C1) plays a critical role in clustering of extra centrosomes various cancer cells and thus could be considered as promising therapeutic target. However, whether is involved the procession renal cell carcinoma (RCC) still remains unclear. In this study, we found that was upregulated RCC tissues responsible for tumorigenesis ( p < 0.001). The high expression correlates with aggressive clinicopathologic parameters. Kaplan‐Meier analysis suggested associated poor...
There are huge differences in the disease burden of kidney cancer (KC) between countries and regions Asia. Therefore, we conducted this study to investigate KC attributable risk factors We obtained data on incidence, prevalence, mortality, disability adjusted life years, sociodemographic index (SDI), Asian from 1990 2021 Global Burden Disease database. Joinpoint regression was used analyze overall trend change The health inequalities Asia were evaluated. correlation SDI assessed....
The diagnostic criteria for cM0 (i+) stage proposed by American Joint Committee on Cancer (AJCC) in renal cell carcinoma (RCC) still remains unclear. present study aimed to establish and validate the of based postoperative circulating tumor cells (CTCs) monitoring patients with localized (LRCC). This enrolled 204 LRCC who received partial or radical nephrectomy from January 2015 November 2021. Cases were randomly divided into test set validation set. correlation between clinicopathological...
Current strategies to treat androgen-independent prostate cancer are associated with a number of challenges and not yet curative. Matrine is naturally occurring alkaloid extracted from the Chinese herb Sophora flavescens. has shown anti-proliferative properties in types cancer, including breast, gastric, lung pancreatic tumors. was also found promote apoptosis inhibit invasion cells. We evaluated antitumor effects matrine on PC-3 The cell cycle progression cells were tested. Matrine-treated...
Circular RNAs (circRNAs) take on regulatory roles in renal cell carcinoma (RCC). The research's goal was to figure out circ-CSPP1's role and molecular mechanism RCC. results clarified that circ-CSPP1 expression enhanced Down-regulating refrained the proliferation, migration, invasion, Warburg effect (aerobic glycolysis), but accelerated apoptosis of RCC cells. luciferase activity assay exhibited could perform as an endogenous sponge for miR-493-5p. Elevating miR-493-5p repressed progression....
The enhancer of zeste 2 polycomb repressive complex subunit (EZH2) gene has been recognized to be a proto‑oncogene and linked human malignancies. However, the additional functions EZH2 in renal cell carcinoma (RCC) are not completely understood. In present study, possible role RCC was identified. demonstrated promote proliferation invasion potential 769‑P cells, inhibition prevent these two processes 786‑O cells. Mechanically, increase phosphorylation signal transducer activator...
Armadillo repeat-containing protein 8 (ARMc8) is a key factor in regulating cell migration, proliferation, tissue maintenance, and tumorigenesis. However, its role bladder cancer remains unknown. Thus, this study we sought to investigate the effect of ARMc8 on epithelial-to-mesenchymal transition (EMT) progress cells induced by transforming growth factor-1 (TGF-1). Our results found that was highly expressed lines. silencing inhibited TGF-1-induced migration invasion suppressed EMT cells....
Notch signaling pathway regulates cancer cell growth. RBPJ is a key transcription factor downstream of receptor activation, whereas the role in carcinogenesis prostate ill-defined.Here, we evaluated effects inhibition on growth cells. We knocked down cells by short hairpin interfering RNA (shRNA). measured an MTT assay. analyzed levels cell-cycle-associated proteins Western blot.We found that shRNA for efficiently inhibited expression cells, resulting significant decrease Further,...
Abstract Transmembrane protein 88 (TMEM88) acts as a novel tumor‐associated protein. The dysregulation of TMEM88 has been observed in several tumor types. However, the relevance tumorigenesis is still contradictory. This study assessed bladder cancer. levels were found to be significantly lower cancer tissue. Upregulation resulted dramatic decrease cellular proliferative and invasive abilities decreased level active β‐catenin prohibited activation Wnt/β‐catenin pathway, an effect that was...
Replication-defective adenovirus vector without both E1 and E3 is one of the most popular tools in transgenic therapies. However, more attention should be paid to vectors mediated-gene modified study on endothelial cells (ECs). To verify possible danger that process, we explored effect ECs this study. By using western blot analysis, showed level CD40 CD40L human umbilical vein (HUVECs) were upregraduated by infection at 100 multiplicity (MOI). The activation induced MOI can partly...