A5101707680- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Colorectal Cancer Screening and Detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory mediators and NSAID effects
- Ferroptosis and cancer prognosis
- Adolescent Sexual and Reproductive Health
- Chronic Lymphocytic Leukemia Research
- Demographic Trends and Gender Preferences
- Crystallography and molecular interactions
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Pluripotent Stem Cells Research
Tongji Hospital
2020-2025
Huazhong University of Science and Technology
2013-2025
Yangzhou University
2025
Henan University of Science and Technology
2024
Sun Yat-sen University Cancer Center
2013-2024
Shandong University of Traditional Chinese Medicine
2024
Sun Yat-sen University
2013-2024
Children's Hospital of Fudan University
2009-2024
Guangxi Medical University
2021-2024
State Key Laboratory of Oncology in South China
2010-2024
Precise methods for postoperative risk stratification to guide the administration of adjuvant chemotherapy (ACT) in localized colorectal cancer (CRC) are still lacking. Here, we conducted a prospective, observational, and multicenter study investigate utility circulating tumor DNA (ctDNA) predicting recurrence risk.
Over 120 small-molecule kinase inhibitors (SMKIs) have been approved worldwide for treating various diseases, with nearly 70 FDA approvals specifically cancer treatment, focusing on targets like the epidermal growth factor receptor (EGFR) family. Kinase-targeted strategies encompass monoclonal antibodies and their derivatives, such as nanobodies peptides, along innovative approaches use of degraders protein interaction inhibitors, which recently demonstrated clinical progress potential in...
Rationale:The transition from acute inflammation to fibrosis following myocardial ischemia-reperfusion (MIR) significantly affects prognosis.Macrophages play a pivotal role in inflammatory damage and repair after MIR.However, the heterogeneity transformation mechanisms of macrophages during this are not well understood.Methods: In study, we used single-cell RNA sequencing (scRNA-seq) mass cytometry examine murine monocyte-derived MIR investigate macrophage subtypes their roles process.S100a9...
Acute myeloid leukemia (AML) is one of the most common types adult acute leukemia. Standard chemotherapies can induce complete remission in selected patients; however, a majority patients eventually relapse and succumb to disease. Thus, development novel therapeutics for AML urgently needed. Human C-type lectin-like molecule-1 (CLL-1) type II transmembrane glycoprotein, its expression restricted cells blasts. Moreover, CLL-1 expressed stem (LSCs), but absent hematopoietic (HSCs), which may...
Abstract Profiling heterologous cell types within tumors is essential to decipher tumor microenvironment that shapes progress and determines the outcome of therapeutic response. Here, we comprehensively characterized transcriptomes 34,037 single cells obtained from 12 treatment‐naïve patients with colorectal cancer. Our comprehensive evaluation revealed attenuated B‐cell antigen presentation, distinct regulatory T‐cell clusters different origin novel polyfunctional associated macrophages...
Objective: This study aims to investigate the prevalence of hearing loss, and analyse major demographics risk factors that influence in older adults China. Design: Cross-sectional investigation. Study sample: Probability proportionate size sampling (PPS) was adopted for this survey. Among 45,052 individuals, 6984 (≥60 years) were selected as subjects study. Results: The loss defined a speech frequency pure tone average more than 25 dB HL better ear 58.85%. Age gender most strongly associated...
Objectives To determine the association between sensory impairment and dementia in Chinese older adults. Design Cross‐sectional. Setting Older adults 31 provinces of China. Participants Individuals aged 65 (N = 250,752). Measurements Psychiatrists ascertained based on International Classification Diseases, 10th Revision . Sensory was measured as only hearing impairment, vision combined (combined impairment). Hearing defined greater than 40 dB loss better ear according to standard World...
We previously reported that a pan-PAD inhibitor, YW3-56, activates p53 target genes to inhibit cancer growth. However, the p53-independent anticancer activity and molecular mechanisms of YW3-56 remain largely elusive. Here, gene expression analyses found ATF4 involved in endoplasmic reticulum (ER) stress response were activated by YW3-56. Depletion greatly attenuated YW3-56-mediated activation mTORC1 regulatory SESN2 DDIT4. Using ChIP-exo method, high-resolution genomic binding sites CEBPB...
Abstract Background 5‐Fluorouracil (5‐FU) and capecitabine‐associated cardiotoxicity ranging from asymptomatic electrocardiography (ECG) abnormalities to severe myocardial infarction has been reported in a number of studies, but such Chinese patients with malignant diseases not investigated date. In the present study, we aimed prospectively evaluate incidence rates clinical manifestations 5‐FU‐ cancer recruited multiple centers China. Methods Among 527 who completed 196 received 5‐FU‐based...
The prognostic nutritional index (PNI) has been widely applied for predicting survival outcomes of patients with various malignant tumors. Although a low PNI predicts poor prognosis in colorectal cancer after tumor resection, the value remains unknown stage III colon undergoing curative resection followed by adjuvant chemotherapy. This study aimed to investigate cancer. Medical records 274 consecutive chemotherapy oxaliplatin and capecitabine between December 2007 2013 were reviewed. optimal...
Square tubes have been widely used as energy absorption components. To investigate the influences of multi-cell configuration and loading arrangement on crashworthiness square tubes, eight kinds were numerically analysed under axial oblique loads. Validation was performed against experimental data. According to complex proportional assessment method, T5-1 tube is found best performance. Next, a parameter study analyse effect geometric parameters crashworthiness. It that s/b ratio thickness...
Electrostatic spraying application is adopted in crop protection to prevent pest infestation, improve product quality and maximize yield. It involves a superposition of charges pesticide spray droplets attract substrate ions at obscured surfaces. The wraparound effect reduces off-target deposition, enhances on-target invariably improves efficiency. system works effectively optimum parameters combination with charging voltages, pressures, height regimes, flow rate, travel speed, electrode...
Aging is one of the factors leading to cancer. Gut microbiota related aging and colorectal cancer (CRC).A total 11 metagenomic data sets CRC were collected from R package curated Metagenomic Data. After batch effect correction, healthy individuals samples divided into three age groups. Ggplot2 Microbiota Process packages used for visual description species composition PCA in samples. LEfSe analysis was performed relative abundance healthy/CRC groups according age. Spearman correlation...
Oxaliplatin (OXA) is a chemotherapy agent commonly used in the treatment of colorectal cancer (CRC). Sodium butyrate (NaB) has an antitumor effect.In total, 30 patients stage III who completed 8 cycles regimens were recruited for this study. The divided into good and bad groups based on efficacy. Gas chromatography-mass spectrometry (GC/MS) was to detect microbial metabolites stool samples from CRC patients. Cell counting kit-8 (CCK-8), Annexin-V APC/7-AAD double staining, Transwell assays,...
As a cornerstone of Chinese traditional culture, opera encapsulates deep historical significance and embodies the national spirit, acting as vital conduit for transmitting intangible cultural heritage. However, in today’s society, this art form confronts challenge becoming marginalized, underscoring urgency its revitalization preservation. This study adopts mixed-methods approach, integrating questionnaire surveys with semi-structured interviews, to explore how perceived value culture shapes...
ABSTRACT Background Homologous recombination deficiency (HRD) exhibits significant associations with the occurrence, progression, and prognosis of breast cancer. However, primary cancer HRD positivity rate is merely 24%. The identification markers associated crucial for development novel therapeutic approaches role oncogene ERCC6L in remains unclear, its interaction radiotherapy has yet to be explored, necessitating further investigation clarification. Methods We employed WGCNA identify...
The age at sexual debut is declining in China, but little known about the relationship between social and demographic characteristics of Chinese youth timing debut.Data were drawn from 2009 National Youth Reproductive Health Survey, which collected background information 22,300 unmarried aged 15-24. Life table analysis was used to estimate gender-specific distributions by age, according urban or rural residence region. Cox proportional hazard regression models then employed identify...
Background High myopia (HM) is a leading cause of blindness that has strong genetic predisposition. However, its and pathogenic mechanisms remain largely unknown. Thus, this study aims to determine the profile individuals from two large Chinese families with HM 200 patients familial/sporadic HM. We also explored mechanism using HEK293 cells mouse model. Methods The participants underwent genome-wide linkage analysis exome sequencing. Visual acuity, electroretinogram response, refractive...