A5085933714- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Perovskite Materials and Applications
- CAR-T cell therapy research
- Circular RNAs in diseases
- PARP inhibition in cancer therapy
- Chalcogenide Semiconductor Thin Films
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research
- Blood properties and coagulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Natural product bioactivities and synthesis
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Quantum Dots Synthesis And Properties
- Spine and Intervertebral Disc Pathology
- Peptidase Inhibition and Analysis
- Nanowire Synthesis and Applications
- Plant Molecular Biology Research
Tongji Hospital
2020-2025
Huazhong University of Science and Technology
2020-2025
Fudan University
2024
Over 120 small-molecule kinase inhibitors (SMKIs) have been approved worldwide for treating various diseases, with nearly 70 FDA approvals specifically cancer treatment, focusing on targets like the epidermal growth factor receptor (EGFR) family. Kinase-targeted strategies encompass monoclonal antibodies and their derivatives, such as nanobodies peptides, along innovative approaches use of degraders protein interaction inhibitors, which recently demonstrated clinical progress potential in...
Background Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial bifunctional enzyme encoded in the nucleus. It plays significant role regulation of glucose, nucleic acid, and folate metabolism, maintains redox balance cells. The present study aimed at elucidating potential function mechanisms MTHFD2 explored correlation between ferroptosis triple-negative breast cancer. Methods expression, survival analysis, clinical were performed using data from various online databases...
Abstract Background SLC25A17, a peroxisomal solute carrier, has been implicated in various physiological and pathological processes. However, its precise roles underlying mechanisms triple-negative breast cancer (TNBC) remain incompletely understood. Methods The expression survival data of were derived from TCGA GEO databases. A variety vitro assays conducted, including proliferation, apoptosis, cell cycle, migration, invasion. Reactive oxygen species (ROS) measured by immunofluorescence...
Precise targeting has become the main direction of anti-cancer drug development. Trophoblast cell surface antigen 2 (Trop-2) is highly expressed in different solid tumors but rarely normal tissues, rendering it an attractive target. Trop-2-targeted antibody-drug conjugates (ADCs) have displayed promising efficacy treating diverse tumors, especially breast cancer and urothelial carcinoma. However, their clinical application still limited by insufficient efficacy, excessive toxicity, lack...
ABSTRACT Background Homologous recombination deficiency (HRD) exhibits significant associations with the occurrence, progression, and prognosis of breast cancer. However, primary cancer HRD positivity rate is merely 24%. The identification markers associated crucial for development novel therapeutic approaches role oncogene ERCC6L in remains unclear, its interaction radiotherapy has yet to be explored, necessitating further investigation clarification. Methods We employed WGCNA identify...
Fermitin family member 1 (FERMT1) is significantly overexpressed in human cancers and associated with poor prognosis, but its contributions to tumorigenesis nasopharyngeal carcinoma (NPC) progression remain unclear.The public GEO database was examined investigate the role of FERMT1. Immunohistochemistry (IHC) staining FERMT1 performed NPC tissues corroborate results. Western blotting qRT-PCR were test expression related proteins mRNAs. Cell counting kit-8 assay (CCK8 assay) colony formation...
Background: Coronavirus disease-2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a newly emerging coronavirus. BSG (basigin) involved in the tumorigenesis of multiple tumors and recently emerged as novel viral entry receptor for SARS-CoV-2. However, its expression profile normal individuals cancer patients are still unclear. Methods: We performed comprehensive analysis distribution tissues, tumor cell lines via bioinformatics experimental...
The crystallization and growth of perovskite crystals are two crucial factors influencing the performance solar cells (PSCs). Moreover, iodoplumbate complexes such as PbI
Background: Head and neck squamous cell carcinoma (HNSCC) is a common malignancy with high mortality morbidity worldwide, but the underlying biological mechanisms of molecules tumor infiltrating-immune cells (TIICs) are still unknown. Methods Results: We obtained mRNAs, lncRNAs, miRNAs expression profiles 546 HNSCC from The Cancer Genome Atlas (TCGA) database to develop ceRNA network. CIBERSORT was employed estimate fraction 22 types TIICs in HNSCC. Univariate multivariate Cox regression...
Osteosarcoma is one of the most common bone tumors in teenagers. We hope to provide a reliable method predict prognosis osteosarcoma and find potential targets for early diagnosis precise treatment. To address this issue, we performed detailed bioinformatics analysis based on Cancer Genome Atlas (TCGA). A total 85 patients with gene expression data clinicopathological features were included study, which was considered entire set. They randomly divided into train set test identified six...
Intervertebral disc degeneration, local lumbar segmental morphology changes, and atrophy of multifidus muscle have been considered to be associated with degenerative spondylolisthesis. However, there remains a great deal controversy. To further investigate their relationship spondylolisthesis, we conducted retrospective study that included 67 patients spondylolisthesis 182 control subjects. Propensity score matching was employed match the case group group. Disc height evaluated by anterior...
Lung adenocarcinoma (LUAD) is a major pathological type of lung cancer. Understanding the mechanism LUAD at molecular level important for clinical decision. In this study, we use bioinformatic analysis to explore prognostic value P4HA1 in and relationship with prognosis tumor-infiltrating immune cells (TIICs). The results showed that expression was significantly higher tumor tissues than normal patients. Upregulated related stage T classification. Kaplan-Meier indicated upregulation worse...
Osteosarcoma is a common malignant primary bone tumor in adolescents and children. Numerous studies have shown that circRNAs were involved the proliferation invasion of various tumors. However, role osteosarcoma remains unclear. Here, we aimed to explore regulatory network among circRNA-miRNA-mRNA osteosarcoma.The circRNA (GSE140256), microRNA (GSE28423), mRNA (GSE99671) expression profiles collected from Gene Expression Omnibus (GEO) database. Differentially expressed circRNAs, miRNAs mRNAs...
Abstract Background Radioresistance challenges the clinical outcomes of nasopharyngeal carcinoma (NPC). The 3‐phosphoinositide‐dependent protein kinase 1 (PDK1) is a crucial PI3K/AKT signaling pathway which has been implicated in process radioresistance. However, role PDK1 NPC remains largely unclear. Methods expression was determined by immunohistochemistry and Western blot. effects RNA interference pharmacologic inhibitor combination with irradiation were investigated. Results...
Background: Chemotherapy-induced thrombocytopenia (CIT) is a common hematological complication in cancer patients.Hetrombopag novel thrombopoietin receptor agonist, which has shown an additive effect stimulating platelet production when combined with recombinant human (rhTPO).Objectives: This multicenter retrospective cohort study aimed to evaluate the efficacy and safety of hetrombopag plus rhTPO compared alone for CIT.Methods: A total 294 patients solid tumors CIT (platelet count < 50×10 9...
Immunotherapy has had a high success rate in treating lung adenocarcinoma (LUAD) for several decades. However, many patients do not benefit from immunotherapy alone. Recent studies revealed that combination of and radiotherapy (RT) stimulates good systemic immune response to LUAD. clinical experimental evidence suggest RT may give rise primary immunodeficiency, facilitating tumor immunity escape. Little is known about the molecular mechanisms whereby stereotactic body (SBRT) influence...
Introduction Tumor microenvironment (TME) has been shown to be extensively involved in tumor development. However, the dynamic change of TME components and their effects are still unclear. Here, we attempted identify TME-related genes that could help predict survival may potential therapeutic targets. Methods Data was collected from UCSC Xena GEO database. ESTIMATE CIBERSORT algorithms were applied estimate proportions TIICs TME. We analyzed gene expression differences immune stromal...
Background: Elevated expression of Copine-1 (CPNE1) has been proved in various cancers; however, the underlying mechanisms by which it affects clear cell renal carcinoma (ccRCC) are unclear. Methods: In this study, we applied multiple bioinformatic databases to analyze and clinical significance CPNE1 ccRCC. Co-expression analysis functional enrichment were investigated LinkedOmics, cBioPortal Metascape. The relationships between tumor immunology explored using ESTIMATE CIBERSORT method....