A5100397012- Ferroptosis and cancer prognosis
- Aortic Disease and Treatment Approaches
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immune cells in cancer
- Occupational and environmental lung diseases
- Sexual function and dysfunction studies
- Aortic aneurysm repair treatments
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Glioma Diagnosis and Treatment
- Arsenic contamination and mitigation
- Aluminum toxicity and tolerance in plants and animals
- Pituitary Gland Disorders and Treatments
- Peripheral Nerve Disorders
- Pain Mechanisms and Treatments
- Urinary Bladder and Prostate Research
- Cardiac electrophysiology and arrhythmias
- Kidney Stones and Urolithiasis Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Nerve Injury and Rehabilitation
- NF-κB Signaling Pathways
- interferon and immune responses
- Inflammasome and immune disorders
Union Hospital
2019-2024
Huazhong University of Science and Technology
2008-2024
Hubei Provincial Center for Disease Control and Prevention
2024
Tongji Hospital
2007-2023
Czech Academy of Sciences, Institute of Biophysics
2008
Tongji University
2007
Background It has been proved that triglyceride glucose-body mass index (TyG-BMI) is a readily available and clinically significant indicator of insulin resistance (IR). Nevertheless, the association between TyG-BMI incident Type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to relationship T2DM explore predictive characteristics TyG-BMI. Methods Our was conducted as longitudinal cohort study. 8,430 men 7,034 women were enrolled analyzed. They both non-diabetic subjects with...
Background Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a mitochondrial bifunctional enzyme encoded in the nucleus. It plays significant role regulation of glucose, nucleic acid, and folate metabolism, maintains redox balance cells. The present study aimed at elucidating potential function mechanisms MTHFD2 explored correlation between ferroptosis triple-negative breast cancer. Methods expression, survival analysis, clinical were performed using data from various online databases...
Background: The development of thoracic aortic aneurysm and dissection (TAAD) is mediated by inflammasome activation, which exacerbates the secretion pro-inflammatory cytokines, chemokines, matrix metalloproteinases (MMPs), reactive oxygen species (ROS). glycolytic enzyme pyruvate kinase M2 (PKM2) has shown a protective role against various disorders with an inflammatory basis, such as sepsis, tumorigenesis, diabetic nephropathy. However, its potential in TAAD not been investigated so far....
Abstract This study aims to develop a prognostic risk prediction model for the development of silicosis among workers exposed silica dust in China. The was performed by using retrospective cohort 3,492 an iron ore, with 33 years follow-up. We developed score system linear combination predictors weighted LASSO penalized Cox regression coefficients. model’s predictive accuracy evaluated time-dependent ROC curves. Six were selected into final (age at entry cohort, mean concentration respirable...
Background Low-density lipoprotein cholesterol (LDL-C) is the primary target of lipid-lowering therapy on management hypercholesterolemia in United States and European guidelines, while apolipoprotein B (apoB) secondary target. The objective was to determine if elevated levels apoB superior LDL-C assessing residual risk coronary atherosclerotic heart disease severity atherosclerosis participants with statin treatment. Methods This study included 131 generalized linear model relative...
Abstract Panaxydol is a naturally occurring non‐peptidyl small molecule isolated from the lipophilic fractions of Panax notoginseng, well‐known Chinese traditional medicine. Previous studies have shown that panaxydol inhibited growth various kinds malignant cell lines. To date, there has been no report concerning effect on inhibition in glioma cells. In this paper, we examined panaxydol's antiproliferation and proapoptotic effects rat C6 cells investigated its mechanism. Cell was determined...
Chronic allograft dysfunction (CAD) resulting from fibrosis is the major limiting factor for long-term survival of lung transplant patients.Myofibroblasts promote in multiple organs, including lungs.In this study, we identified PLK1 as a promoter myofibroblast differentiation and investigated mechanism by which its inhibition alleviates transplant-associated obliterative bronchiolitis (OB) during CAD.High-throughput bioinformatic analyses experiments using murine heterotopic tracheal...
Given the similarities in clinical manifestations of cystic-solid pituitary adenomas (CS-PAs) and craniopharyngiomas (CPs), this study aims to establish validate a nomogram based on preoperative imaging features blood indices differentiate between CS-PAs CPs.A departmental database was searched identify patients who had undergone tumor resection January 2012 December 2020, those diagnosed with or CPs by histopathology were included. Preoperative magnetic resonance (MRI) as well retrieved...
Abstract Thoracic aortic aneurysm (TAA), a serious cardiovascular disease that causes morbidity and mortality worldwide. At present, few biomarkers can accurately diagnose the appearance of TAA before dissection or rupture. Our research has intention to investigate developing applicable for promising clinically diagnostic probable regulatory targets TAA. In our research, we built correlation networks utilizing expression profile peripheral blood mononuclear cell obtained from public...
Background: Elevated expression of Copine-1 (CPNE1) has been proved in various cancers; however, the underlying mechanisms by which it affects clear cell renal carcinoma (ccRCC) are unclear. Methods: In this study, we applied multiple bioinformatic databases to analyze and clinical significance CPNE1 ccRCC. Co-expression analysis functional enrichment were investigated LinkedOmics, cBioPortal Metascape. The relationships between tumor immunology explored using ESTIMATE CIBERSORT method....
Objective Insulin plays a central role in the regulation of energy and glucose homeostasis, insulin resistance (IR) is widely considered as “common soil” cluster cardiometabolic disorders. Assessment sensitivity very important preventing treating IR-related disease. This study aims to develop validate machine learning (ML)-augmented algorithms for assessment community primary care settings. Methods We analyzed data 9358 participants over 40 years old who participated population-based cohort...
Objective: Spinal cord injury often leads to the loss of penile sensation, and severely affects individual's sexual function. The present study aimed restore sensory pathway through end-to-side dorsal root (DR) transfer neurorrhaphy in rats, preliminarily verified feasibility operation.Design: 40 male adult Sprague-Dawley rats were divided into three groups. In model (n = 20) resection 10) groups, right L6 DR, S1 contralateral branch nerve penis (DNP) transected. distal stump DR group was...
Abstract Background: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), one of mitochondrial enzymes, is involved in folate and nucleic acid metabolism maintains the cellular redox balance. However, function MTHFD2 bladder cancer still poorly characterized. This study was designed to elucidate effect regulatory mechanism on cells explore relationships between immune cell infiltration tumor microenvironment (TME). Methods: The data from Oncomine, TIMER, Cancer Genome Atlas (TCGA) Human...
Abstract Background: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), one of mitochondrial enzymes, is involved in folate and nucleic acid metabolism maintains the cellular redox balance. However, function MTHFD2 bladder cancer still poorly characterized. This study was designed to elucidate effect regulatory mechanism on cells explore relationships between immune cell infiltration tumor microenvironment (TME). Methods: The data from Oncomine, TIMER, Cancer Genome Atlas (TCGA) Human...