A5059997287- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Breast Cancer Treatment Studies
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Autophagy in Disease and Therapy
- Neurosurgical Procedures and Complications
- Trigeminal Neuralgia and Treatments
- Barrier Structure and Function Studies
- Neuroscience and Neuropharmacology Research
- Breast Implant and Reconstruction
- Ginseng Biological Effects and Applications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Glycation End Products research
- Reconstructive Surgery and Microvascular Techniques
- Facial Nerve Paralysis Treatment and Research
- Breast Lesions and Carcinomas
- Andrographolide Research and Applications
- Cannabis and Cannabinoid Research
- Eicosanoids and Hypertension Pharmacology
- Pharmacological Effects of Natural Compounds
Huizhou Central People's Hospital
2025
Tongji University
2012-2023
Tongji Hospital
2010-2023
Central South University
2005-2021
Xiangya Hospital Central South University
2005-2021
Hunan Cancer Hospital
2018
University of California, Los Angeles
2018
Lac Courte Oreilles Ojibwa Community College
2006
Shanghai Ninth People's Hospital
2003
Previous studies reported that URB597 (URB) had therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuroinflammation and autophagy dysfunction. However, the interaction mechanisms underlying CCH-induced abnormal excessive remain unknown. In this study, we investigated roles of impaired in nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing (NLRP) 3 inflammasome activation rat hippocampus under condition induced CCH as well...
Abstract Aims Clear roles and mechanisms in explaining gut microbial dysbiosis metabolites short‐chain fatty acids (SCFAs) alterations chronic cerebral ischemic pathogenesis have yet to be explored. In this study, we investigated hypoperfusion (CCH)‐induced microbiota metabolic profiles of SCFAs as well the effects fecal transplantation (FMT) treatment on CCH‐induced hippocampal neuronal injury. Methods Bilateral common carotid artery occlusion (BCCAo) was used establish CCH model. Gut feces...
Abstract Augmentation of endoplasmic reticulum (ER) stress may trigger excessive oxidative stress, which induces mitochondrial dysfunction. The fatty acid amide hydrolase inhibitor, URB597, shows anti-oxidation characteristics in multiple neurological disorders. present study aimed to determine whether inhibition ER was involved the protective effects URB597 against chronic cerebral hypoperfusion (CCH)-induced cognitive impairment. Hippocampal HT-22 cells were exposed oxygen-glucose...
Abstract URB597 (URB) has therapeutic potential for treating chronic cerebral hypoperfusion (CCH)-induced neuronal death. The present study investigated the protective effects of URB on autopahgy and mitophagy in a CCH model as well underlying mechanisms. ultrastructural changes were examined by electron microscopy. mitochondrial membrane was assessed immunofluorescence. expressions autophagy-related proteins (beclin-1, p62, LC3), lysosome-related (CTSD LAMP1), mitophagy-related (BNIP3, cyt...
Ischemic stroke, a cerebrovascular disease worldwide, triggers cascade of pathophysiological events, including blood-brain barrier (BBB) breakdown. Brain microvascular endothelial cells (BMECs) play vital role in maintaining BBB function. The injury BMECs may worsen neurovascular dysfunction and patients’ prognosis. Therefore, uncover the principal molecular mechanisms involved disruption stroke becomes pressing. endocannabinoid system (ECS) has been implicated increasingly physiological...
Abstract Background Little is known about the association between gut microbiota and intestinal injury under a state of chronic cerebral hypoperfusion (CCH). Here, effects short-chain fatty acids (SCFAs), as important metabolic products, on function potential mechanisms after CCH were investigated. Methods Rats subjected to bilateral common carotid artery occlusion (BCCAo) induce CCH. The metabolites SCFAs assessed by 16S rRNA sequencing targeted metabolomics, respectively. Transcriptomic...
Objective This study aims to explore the clinical features, diagnosis, and treatment of infantile fibrosarcoma (IFS) associated with BRAF mutations, goal enhancing clinicians’ understanding this rare genetic variant its relationship IFS. Methods The China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP PubMed, Center for Biotechnology Information (NCBI) were searched using keywords “infantile fibrosarcoma” “congenital relevant articles published before August 2024. A total...
In a rat model, we studied the time courses of vascular endothelial growth factor (VEGF) expression and angiogenesis induced by chronic cerebral hypoperfusion in brain, investigated histological basis normal-perfusion pressure breakthrough.Twenty-one Sprague-Dawley rats were randomly divided into control group (n = 3) model assessed at various points after creation carotid artery-jugular vein fistula (12 h, n 3; 24 72 7 d, 21 90 3). The VEGF messenger ribonucleic acid (mRNA) protein brain...
Objective: To evaluate the operative outcomes and mechanisms of microvascular decompression in treating typical atypical trigeminal neuralgia. Methods: A group 45 patients with neuralgia 17 treated by micro-vascular from 2000 to 2002 were reviewed, including their clinical presentations, findings, outcomes. Results: Of neuralgia, mean duration was 3.1 years, age pain onset 60.3 years. Single division involved 20 (44.4%), 2 or 3 divisions other 25 (55.6%). During operation, artery compression...
JOURNAL/nrgr/04.03/01300535-202404000-00034/inline-graphic1/v/2023-09-09T133047Z/r/image-tiff Upregulation of vascular endothelial growth factor A/basic fibroblast (VEGFA/bFGF) expression in the penumbra cerebral ischemia can increase volume, reduce lesion and enhance neural cell proliferation differentiation, thereby exerting neuroprotective effects. However, beneficial effects endogenous VEGFA/bFGF are limited as their is only transiently increased. In this study, we generated multilayered...
Due to controversial surgical treatment for hemorrhagic moyamoya disease (MMD), a large proportion of these patients chose conservative treatment. The aim this study was assess cognitive function in adult with MMD who received no revascularization.Twenty-six only intraventricular hemorrhage (IVH) confirmed by positive computed tomography and magnetic resonance imaging scan, 20 spontaneous IVH whose digital subtraction angiography results were negative, 30 healthy controls identified matched...
Abstract Background The aim of this study was to compare quilting suture with conventional on the formation seroma at pectoral area after mastectomy (ME) sentinel lymph nodes biopsy (SLN) or axillary dissection (ALND) for breast cancer. Methods Two hundred thirty-five consecutive cancer patients were retrospectively analyzed. primary outcome incidence Grade 2 3 anterior within 1 month postoperatively. We categorized into early late according drainage removal time. Cox regression used...
Introduction: Brain ischemia is a common neurological disorder worldwide that activates cascade of pathophysiological events involving decreases in oxygen and glucose levels. Despite substantial efforts to explore its pathogenesis, the management ischemic neuronal injury remains an enormous challenge. Accumulating evidence suggests VEGF modified nanofiber (NF) materials fatty-acid amide hydrolase (FAAH) inhibitor URB597 exert influence on alleviating brain damage. We aimed further...
Object. A new experimental model of chronic cerebral hypoperfusion was developed to study the effects systemic arterial shunting and obstruction primary vessel that drains intracranial venous blood on perfusion pressure (CPP), as well pathological changes during restoration normal pressure. Methods. Twenty-four Sprague—Dawley rats were randomly assigned either a sham-operated group, an arteriovenous fistula (AVF) or group (eight each). The animal readied by creating through end-to-side...