A5100660325- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Epigenetics and DNA Methylation
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Lipid metabolism and disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
Southern Medical University
2023-2025
Nanfang Hospital
2023-2025
Xiangya Hospital Central South University
2015-2024
Central South University
2014-2024
Hunan Provincial Center for Disease Control and Prevention
2024
Hunan Cancer Hospital
2019-2023
Qingdao Eighth People's Hospital
2021
Texas A&M University
2020
Tumor Hospital of Xinjiang Medical University
2017
Xinjiang Medical University
2017
Chronic hypoxia is the most common cause of secondary pulmonary hypertension, for which mechanisms are still unclear. Recent studies implicated an important role microRNAs (miRNAs) in hypoxia-mediated responses various cellular processes, including cell apoptosis and proliferation. Therefore, we hypothesized that these regulatory molecules might be etiology hypoxic hypertension. Here show miRNA-328, a posttranscriptional regulator, was drastically downregulated artery (PA) after assault. PA...
Breast cancer (BC) is the most common malignancy in women with unfavorite prognosis. Tanshinone IIA (Tan IIA) inhibits BC progression, however, underlying mechanism remains largely undefined. The cytotoxicity of Tan was assessed by CCK-8 and LDH assays. Ferroptosis monitored level MDA, Fe2+, lipid ROS GSH. IHC western blot were employed to detect localization expression SLC7A11, PIAS4, KDM1A other key molecules. SUMOylation SLC7A11 detected Ni-beads pull-down assay co-IP. Luciferase ChIP...
Long non‐coding RNA (lncRNA) is involved in the regulation of tumorigenesis and metastasis. In this study, we focused on clinical relevance, biological effects, molecular mechanisms lncRNA differentiation antagonizing non‐protein coding (DANCR) breast cancer. We compared expression DANCR between cancer normal tissues, cell lines epithelial cells using quantitative real‐time PCR (qRT‐PCR) analysis. By knocking down overexpressing DANCR, assessed its significance regulating viability (MTT...
Patients with primary aldosteronism (PA) are at a high risk of cardiovascular diseases (CVD) and metabolic syndrome. Notable inflammatory fibrotic changes differential microRNA (miRNA) expression profiles in the perirenal fat observed PA may contribute to this increased risk, however, which has not been fully elucidated. This study aimed explore role miR-24-3p circulating inflammation its correlation CVD patients PA. Perirenal thickness (PRFT) measured by computed tomography (CT), fat,...
The focus of the study is to examine function TYMSOS in immune escape breast cancer, which most frequently diagnosed malignancy among women globally. Our demonstrated that upregulated was associated with unfavorable prognosis and cancer. promoted malignant phenotypes cancer cells, reduced cytotoxicity NK92 cells on these cells. CBX3 a downstream effector TYMSOS-induced Mechanistic studies showed facilitated CBX3-mediated transcriptional repression ULBP3, it also SYVN1-mediated...
The aim of this study is to explore the various modes action miR-497 has on human cervical cancer (CC) cell behavior. We also speculate that achieves its anti-tumor role by governing RAF-1 via MAPK/ERK signaling pathway. CC tissues with corresponding adjacent normal were collected from 168 patients. RAF-1-positive cells identified means immunohistochemistry in tissues. A series inhibitors, mimics and siRNA against introduced validate regulatory mechanisms for RAF-1. Quantitative real-time...
The function of long non-coding RNA (lncRNA) MALAT1 in regulating triple-negative breast cancer (TNBC) stemness and tumorigenesis was investigated.Sphere formation colony assays coupled with flow cytometry were employed to evaluate the percentage CD44high/CD44low cells, ALDH+ cells performed stemness. Bisulfite sequencing PCR (BSP) detect methylation level MALAT1. Tumor xenograft experiment vivo. Finally, dual-luciferase reporter RIP verify binding relationship between miR-137.Our results...
Abstract Triple-negative breast cancer (TNBC) accounts for 15–20% of cases in the United States, lacks targeted therapeutic options, and is associated with a 40–80% risk recurrence. Thus, identifying actionable targets treatment-naïve chemoresistant TNBC critical unmet medical need. To address this need, we performed high-throughput drug viability screens on human tumor cells isolated from 16 patient-derived xenograft models primary TNBC. The span range subtypes exhibit diverse set putative...
Aim: This study aimed to evaluate the effects of centromere protein W (CENPW, also known as CUG2) in hepatocellular carcinoma (HCC). Methods: CENPW expression HCC tissues and cells was detected by RT-qPCR assay. CCK-8 colony formation assay were used assess cell proliferation. Wound healing Transwell detect migration invasion, respectively. The flow cytometry analyze cycle distribution apoptosis. Results: upregulated cells. Knockdown inhibited proliferation, migration, invasion induced G0/G1...
Diabetic kidney disease (DKD) has become the leading cause of end-stage (ESKD) in most countries. Recently, long noncoding RNA XIST been found involved development DKD. A total 1184 hospitalized patients with diabetes were included and divided into four groups based on their estimated glomerular filtration rate (eGFR) urinary albumin to creatinine ratio (UACR): normal control group (nDKD), DKD normoalbuminuric reduced eGFR (NA-DKD), albuminuria but without (A-DKD), (Mixed), then clinical...