A5101958193- Reproductive Biology and Fertility
- Insect Resistance and Genetics
- Sperm and Testicular Function
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- Animal Genetics and Reproduction
- Genetically Modified Organisms Research
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Luminescence and Fluorescent Materials
- Respiratory Support and Mechanisms
- Ferroptosis and cancer prognosis
- Phytochemistry and Biological Activities
- Immunotherapy and Immune Responses
- Prenatal Screening and Diagnostics
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Advanced Fluorescence Microscopy Techniques
- Platelet Disorders and Treatments
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
Northeast Agricultural University
2024-2025
Tongji Hospital
2023-2025
Huazhong University of Science and Technology
2003-2025
Ministry of Agriculture and Rural Affairs
2025
Chongqing Medical University
2015-2024
Children's Hospital of Chongqing Medical University
2021-2024
Chongqing Maternal and Child Health Hospital
2013-2024
Weatherford College
2024
Shanghai Jiao Tong University
2019-2023
XinHua Hospital
2019-2023
Over 120 small-molecule kinase inhibitors (SMKIs) have been approved worldwide for treating various diseases, with nearly 70 FDA approvals specifically cancer treatment, focusing on targets like the epidermal growth factor receptor (EGFR) family. Kinase-targeted strategies encompass monoclonal antibodies and their derivatives, such as nanobodies peptides, along innovative approaches use of degraders protein interaction inhibitors, which recently demonstrated clinical progress potential in...
Long noncoding RNAs (lncRNAs) have several known functions in plant development, but their possible roles responding to disease remain largely unresolved. In this study, we described a comprehensive disease-responding lncRNA profiles defence against cotton fungal Verticillium dahliae. We further revealed the conserved and specific characters of process between two species. Conservatively for species, found expression dominance induced lncRNAs Dt subgenome, indicating biased induction pattern...
Catalytic oxidation of non-activated aliphatic alcohols with molecular oxygen is rather challenging, especially in an aqueous medium the absence additional base. Bismuth usually used as a promoter platinum-based catalysts. In this work, bismuth oxide was explored support, and Pt0 nanoparticles supported on (Pt/Bi2O3) exhibited high activity for aerobic n-butanol using water solvent base under optimized conditions. Besides n-butanol, liquid primary low solubility could also be smoothly...
Abstract Background SLC25A17, a peroxisomal solute carrier, has been implicated in various physiological and pathological processes. However, its precise roles underlying mechanisms triple-negative breast cancer (TNBC) remain incompletely understood. Methods The expression survival data of were derived from TCGA GEO databases. A variety vitro assays conducted, including proliferation, apoptosis, cell cycle, migration, invasion. Reactive oxygen species (ROS) measured by immunofluorescence...
Long non-coding RNAs (lncRNAs) can play significant regulatory roles in cells that affect the development and acquired drug resistance of lung cancer. Herein, we report lncRNA linc00665 is significantly upregulated non-small cell cancer (NSCLC) tissues compared with adjacent normal tissues. affects sensitivity NSCLC to chemotherapy cisplatin (DDP), making it a potential target for treatment NSCLC. Functional experiments showed enhanced proliferation migration vivo vitro, knocking down could...
Precise targeting has become the main direction of anti-cancer drug development. Trophoblast cell surface antigen 2 (Trop-2) is highly expressed in different solid tumors but rarely normal tissues, rendering it an attractive target. Trop-2-targeted antibody-drug conjugates (ADCs) have displayed promising efficacy treating diverse tumors, especially breast cancer and urothelial carcinoma. However, their clinical application still limited by insufficient efficacy, excessive toxicity, lack...
ABSTRACT Background Homologous recombination deficiency (HRD) exhibits significant associations with the occurrence, progression, and prognosis of breast cancer. However, primary cancer HRD positivity rate is merely 24%. The identification markers associated crucial for development novel therapeutic approaches role oncogene ERCC6L in remains unclear, its interaction radiotherapy has yet to be explored, necessitating further investigation clarification. Methods We employed WGCNA identify...
Abstract Powdery mildew (PM) caused by Eeysiphe heraclei is a serious concern in Heracleum moellendorffii Hance. E. biotrophic fungus that absorbs glucose as the major carbon energy source, using haustoria after infection. However, mechanisms of sugar efflux from host cells to remain undetermined. Our previous study revealed infection altered transfer and distribution H. moellendorffii, increased concentrated infected regions. Here, RNA‐sequencing was used identify key transporter, HmSWEET1,...
Increasing evidence has suggested that dysregulation of microRNAs (miRNAs) could contribute to tumor progression. The miR-34 family is directly transactivated by suppressor p53 which frequently mutated in various cancers; however, the effect miR-34a on ovarian cancer cells remains unclear. aim paper was study expression and miR-34a's relation cell proliferation metastasis vitro. determined quantitative RT-PCR a panel 60 human samples. Functional characterization accomplished reconstitution...
The cross-coupling reactions have been used in C–C bond formation which can be extensively optoelectronic materials for organic light-emitting diodes, photovoltaics, and chemical biosensing. Here, we report 2-fold geminal at 1,1-dibromoolefins via of aromatic boronic esters over Pd catalysts multiple topological configurations π-conjugated molecules. We employ a series recipes from precursor toolbox to produce macrocycles, conjugated dendrimers, linear polymers, microporous polymers...
Failed fertilization after conventional IVF is one of the most frustrating experiences in assisted reproductive technology. “Late” rescue ICSI may be not an optimal strategy for treating unfertilized oocytes. Short co-incubation gametes combined with early has some advantages complete failure IVF. We evaluate and time ICSI. A total 180 patients underwent short treatment (study group). 494 male factor infertility served as a control group. Clinical pregnancy rate, implantation live birth rate...
Aggregation-induced enhanced near-infrared dyes based on terrylenediimide–tetraphenylethene dyads with a maximum emission wavelength of up to 800 nm.
We have designed and synthesized an amphiphilic photoswitchable fluorophore, PEGylated perylenemonoimide-dithienylethene (PEG-PMI-DTE), which exhibits evident bistable photochromism, fluorescence switching, fatigue resistance. The fine nanostructures of liposomes can be observed directly under super-resolution fluorescent microscopy by aid the fluorophore as a staining agent, with optical resolution 30 nm.
China is currently the only country that has commercialized genetically engineered tree species, and this attracted worldwide attention. As a perennial transgenic poplar long growth cycle needs to be tested for long-term ecological risks. The main purpose of study was explore safety poplars in arthropod community, physical chemical properties soil, gene flow, soil microbial diversity. found could effectively inhibit number pests. Moreover, 741 did not affect stability community. Studies on...
The present study aimed to investigate the effects of dexmedetomidine on emergence delirium (ED) in pediatric patients undergoing cardiac surgery.Fifty children both sexes aged 1-6 years weighing 10-25 kilograms, with American Society Anesthesiologists (ASA) physical status grade II, sevoflurane-based general anesthesia for elective surgery, were randomly assigned two groups. group (group D, N.=25) received 0.5 µg/kg over 10 minutes, followed by an infusion at µg/kg/h until end whereas...
Ginsenosides are the major effective ingredients responsible for pharmacological effects of ginseng. Malonyl ginsenosides natural that contain a malonyl group attached to glucose unit corresponding neutral ginsenosides.Medium-pressure liquid chromatography and semipreparative high-performance were used isolate purified compounds their structures determined by extensive one-dimensional- two-dimensional nuclear magnetic resonance (NMR) experiments.A new saponin, namely malonyl-ginsenoside Re,...
In this prospective cohort study, the effects of a time-lapse monitoring system on embryo quality and clinical pregnancy outcomes were assessed. A total 608 patients undergoing in vitro fertilization between April 2013 June 2014 at our institution recruited for study group-matched into (TLM) (N = 304) or standard incubator (SI) 304). The patients' characteristics TLM SI groups not significantly different. group showed higher transferable ratio Day 3 (61.65% vs. 52.87%; p < 0.0010, RR =1.10...
The objective of this prospective cohort study was to investigate whether cryopreservation cleavage or blastocyst stage embryos improves in vitro fertilization outcomes recurrent implantation failure (RIF) patients. comprised 575 patients who were allocated receive either single frozen/thawed blastocyst-stage transfer (SBT) double-cleavage-stage embryo (DET). clinical pregnancy rate, and ongoing rate higher the SBT group compared with DET (41.15% vs. 27.11%, p < 0.001; 41.15% 19.28%, 40.03%...
Abstract Postovulatory aging leads to the decline in oocyte quality and subsequent impairment of embryonic development, thereby reducing success rate assisted reproductive technology (ART). Potential preventative strategies preventing oocytes from associated underlying mechanisms warrant investigation. In this study, we identified that cordycepin, a natural nucleoside analogue, promoted vitro, as indicated by reduced fragmentation, improved spindle/chromosomes morphology mitochondrial...