A5100351608- Neonatal Respiratory Health Research
- Cancer Diagnosis and Treatment
- Metallurgical and Alloy Processes
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Peroxisome Proliferator-Activated Receptors
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- MicroRNA in disease regulation
- interferon and immune responses
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Electronic Packaging and Soldering Technologies
- CRISPR and Genetic Engineering
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- Cancer, Lipids, and Metabolism
- Congenital Diaphragmatic Hernia Studies
- Prostate Cancer Treatment and Research
- Tracheal and airway disorders
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
Tongji Hospital
2008-2025
Huazhong University of Science and Technology
2008-2025
Hefei University of Technology
2023-2025
University of Cincinnati Medical Center
2011-2024
Capital Medical University
2019-2024
Weifang People's Hospital
2024
Tianjin Medical University General Hospital
2024
Tianjin Medical University Cancer Institute and Hospital
2024
Institute of Hematology & Blood Diseases Hospital
2024
United States University
2024
A phase II trial of the oral epidermal growth factor receptor (EGFR) inhibitor erlotinib in patients with gastroesophageal adenocarcinomas stratified according to primary tumor location into two groups: junction (GEJ)/cardia and distal gastric adenocarcinomas.Patients a histologically proven diagnosis adenocarcinoma GEJ or stomach (ST) that was unresectable metastatic; presence measurable disease; no prior chemotherapy for advanced metastatic cancer; Zubrod performance status (PS) 0 1;...
Objective. Subepithelial tumors (SETs) in the stomach are usually considered benign. However, some do have potential for malignant transformation, especially when originating muscularis propria (MP). Our study aimed to evaluate clinical efficacy and safety of endoscopic submucosal dissection (ESD) gastric SETs MP. Material methods. A total 145 MP 144 patients were treated by ESD between September 2008 December 2012. Characteristics SETs, therapeutic outcomes, pathologic characteristics,...
Silicon-based broadband photodetectors (BBPDs) are extensively utilized in both the civilian and military fields due to their advanced fabrication processes superior optoelectronic properties. However, most silicon-based BBPDs exhibit significantly reduced response visible range compared near-infrared band, which limits further application systems. In this study, a visible-light-enhanced Ti3C2Tx MXene/Si NW heterojunction BBPD is constructed by employing small diameter silicon nanowire (Si...
Castration-resistant prostate cancer (CRPC) is an advanced-stage (PC) associated with high mortality. We reported that G-1, a selective agonist of G protein-coupled receptor 30 (GPR30), inhibited PC cell growth by inducing G2 cycle arrest and arrested PC-3 xenograft growth. However, the therapeutic actions G-1 their relationships androgen in vivo are unclear. Using LNCaP to model during androgen-sensitive (AS) versus castration-resistant (CR) phase, we found CR but not AS tumors no...
In patients with borderline resectable pancreas cancers, clinicians frequently consider radiographic response as the primary driver of whether should be offered surgical intervention following neoadjuvant therapy (NT). We sought to determine any correlation between and pathologic rates NT.Between 2005 2015, 38 at a tertiary care referral center underwent NT followed by pancreaticoduodenectomy for cancer. Radiographic after completion surgery were graded according RECIST Evans' criteria,...
Pancreas ductal adenocarcinoma (PDAC) is one the most aggressive cancers and associated with very high mortality, requiring development of novel treatments. The mitochondrial voltage-gated potassium channel, Kv1.3 emerging as an attractive oncologic target but its function in PDAC unknown. Here, we evaluated tissue expression resected from 55 patients using immunohistochemistry (IHC) show that all tumors expressed 60% tumor specimens having expression. In Pan02 cells, recently developed...
This study investigated whether expression of the common cystic fibrosis transmembrane conductance regulator (CFTR) mutant F508del in apical membrane enterocytes confers increased bicarbonate secretory capacity on intestinal epithelium mice compared to that CFTR knockout (KO) mice. KO mice, (F508del) and wild-type (WT) littermates were bred FVB/N background. isolated brush border (BBM) contained approximately 5-10% fully glycosylated band C protein WT BBM. Similarly, forskolin (FSK)-induced,...
Benign metastasizing leiomyoma (BML) is a rare disease that usually occurs in women of reproductive age. They typically have history uterine treated with hysterectomy. BML can metastasize to distant organs, the lung being most common organ. We report two patients who presented benign lung. Our first case was fifty-two-year-old female multiple masses, past medical underwent hysterectomy 17 years ago. A CT-guided biopsy showed appearing spindle cells and pathology confirmed her diagnosis...
Abstract Our previous study indicated that adhesion molecule catenin alpha‐like 1(CTNNAL1) is downregulated in airway epithelial cells of asthma patients and animal model but little known about how the CTNNAL1 affects pathogenesis. To reveal direct relationship between CTNNAL1, CTNNAL1‐deficient mouse bronchopulmonary tissue was constructed by introducing CTNNAL1‐siRNA sequence using adeno‐associated virus (AAV) as vector. The established stimulation house dust mite (HDM). After...
Glioblastoma is a malignant primary brain tumor with poor prognosis median survival of only 12‑15 months. The high mortality rate this disease mainly due to the chemoresistance resulting from various reasons. Ubiquitin‑specific protease 4 (USP4) has recently been found be elevated in types cancer through regulating P53 activity. However, whether USP4 responsible for glioblastoma not clear. In present study, expression tissues and cell lines, as well its association temozolomide (TMZ) was...
Copper (Cu) is an essential trace element required for mitochondrial respiration. Late-stage clear cell renal carcinoma (ccRCC) accumulates Cu and allocates it to cytochrome c oxidase. We show that drives coordinated metabolic remodeling of bioenergy, biosynthesis redox homeostasis, promoting tumor growth progression ccRCC. Specifically, induces TCA cycle-dependent oxidation glucose its utilization glutathione protect against H
Most kidney cancers are renal cell carcinomas (RCC). RCC lacks early warning signs and 70 % of patients with develop metastases. Among them, 50 having skeletal metastases developed a dismal survival less than 10 at 5 years. Therefore, exploring the key driving proteins pathways involved in bone metastasis could benefit patients' therapy prolong their survival. We examined difference between OS-RC-2 cells OS-RC-2-BM5 (subpopulation from OS-RC-2) proteomics. Then we employed Western-blot,...
Background: Acute kidney injury is the most common complication after liver transplantation. Sodium bicarbonate Ringer's solution a new type of crystalloid that has been recently used in clinical setting. Whether sodium reduces occurrence postoperative AKI and improves outcomes transplantation patients not clear. Objective: To compare effects versus normal saline on acute following classic orthotopic Methods: Sixty-four participants were randomly assigned to Ringers (BRS) group or (NS)...
A series of novel narrowband photodetectors based on MAPbBr 3− n X (X = Cl, I) single-crystal films were fabricated, and further applied to the identification different color LEDs employed in traffic lights.