Amelia Martines
A5089784216- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Trace Elements in Health
- Cancer Genomics and Diagnostics
- Renal and Vascular Pathologies
- Chronic Lymphocytic Leukemia Research
- Nuclear Receptors and Signaling
- Amino Acid Enzymes and Metabolism
University of Cincinnati
2024
University of Cincinnati Medical Center
2024
Istituto Oncologico Veneto
2022
Molecular Oncology (United States)
2022
<p>Bulk RNA and spatial transcriptomics analysis of ccRCC.</p>
<p>Characterization of subpopulations cancer cells identified by scRNA-seq.</p>
<p>Expression of SLC25A40 glutathione transporter in RCC cells.</p>
<div>Abstract<p>Copper (Cu) is a cofactor of cytochrome c oxidase (CuCOX), indispensable for aerobic mitochondrial respiration. This study reveals that advanced clear cell renal carcinomas (ccRCC) accumulate Cu, allocating it to CuCOX. Using range orthogonal approaches, including metabolomics, lipidomics, isotope-labeled glucose and glutamine flux analysis, transcriptomics across tumor samples, lines, xenografts, patient-derived xenograft models, combined with genetic...
<p>Glucose metabolism in CuHi and CuLo cells.</p>
<p>Cu regulates metabolism and CuCOX is necessary for Cu-induced tumor growth.</p>
<p>Accumulation of Cu and its allocation to CuCOX correlates with the progression ccRCC drives tumor growth.</p>
<p>Cu induces NRF2-dependent activation of glutathione biosynthesis.</p>
<p>Characterization of subpopulations cancer cells identified by scRNA-seq.</p>
<p>Cu regulates metabolism and CuCOX is necessary for Cu-induced tumor growth.</p>
<p>Expression of SLC25A40 glutathione transporter in RCC cells.</p>
<p>Bulk RNA and spatial transcriptomics analysis of ccRCC.</p>