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Megan E. Bischoff

ORCID: 0000-0002-7950-2825
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A5043911563
Research Areas
  • Renal cell carcinoma treatment
  • Ferroptosis and cancer prognosis
  • Trace Elements in Health
  • Autophagy in Disease and Therapy
  • Endoplasmic Reticulum Stress and Disease
  • Heavy Metal Exposure and Toxicity
  • Epigenetics and DNA Methylation
  • Renal and Vascular Pathologies
  • Cancer Genomics and Diagnostics
  • Radiomics and Machine Learning in Medical Imaging
  • Extracellular vesicles in disease
  • Amino Acid Enzymes and Metabolism
  • Nuclear Receptors and Signaling
  • Cancer, Hypoxia, and Metabolism

University of Cincinnati Medical Center
 2021-2024

University of Cincinnati
 2024

 Supplementary Figure S7 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Bulk RNA and spatial transcriptomics analysis of ccRCC.</p>

10.1158/2159-8290.28367907 preprint EN cc-by 2025-02-07
 Supplementary Figure S6 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Characterization of subpopulations cancer cells identified by scRNA-seq.</p>

10.1158/2159-8290.28367910 preprint EN cc-by 2025-02-07
 Supplementary Figure S5 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Expression of SLC25A40 glutathione transporter in RCC cells.</p>

10.1158/2159-8290.28367913 preprint EN cc-by 2025-02-07
 Data from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<div>Abstract<p>Copper (Cu) is a cofactor of cytochrome c oxidase (CuCOX), indispensable for aerobic mitochondrial respiration. This study reveals that advanced clear cell renal carcinomas (ccRCC) accumulate Cu, allocating it to CuCOX. Using range orthogonal approaches, including metabolomics, lipidomics, isotope-labeled glucose and glutamine flux analysis, transcriptomics across tumor samples, lines, xenografts, patient-derived xenograft models, combined with genetic...

10.1158/2159-8290.c.7662960 preprint EN 2025-02-07
 Supplementary Figure S4 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Glucose metabolism in CuHi and CuLo cells.</p>

10.1158/2159-8290.28367916 preprint EN cc-by 2025-02-07
 Supplementary Figure S2 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Cu regulates metabolism and CuCOX is necessary for Cu-induced tumor growth.</p>

10.1158/2159-8290.28367922 preprint EN cc-by 2025-02-07
 Supplementary Figure S1 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Accumulation of Cu and its allocation to CuCOX correlates with the progression ccRCC drives tumor growth.</p>

10.1158/2159-8290.28367925 preprint EN cc-by 2025-02-07
 Supplementary Figure S3 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Cu induces NRF2-dependent activation of glutathione biosynthesis.</p>

10.1158/2159-8290.28367919 preprint EN cc-by 2025-02-07
 Supplementary Figure S6 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Characterization of subpopulations cancer cells identified by scRNA-seq.</p>

10.1158/2159-8290.28555218 preprint EN cc-by 2025-03-07
 Supplementary Figure S2 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Cu regulates metabolism and CuCOX is necessary for Cu-induced tumor growth.</p>

10.1158/2159-8290.28555230 preprint EN cc-by 2025-03-07
 Supplementary Figure S5 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Expression of SLC25A40 glutathione transporter in RCC cells.</p>

10.1158/2159-8290.28555221 preprint EN cc-by 2025-03-07
 Supplementary Figure S7 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
OPENALEX - Publications 
Megan E. Bischoff Behrouz Shamsaei Juechen Yang Dina Secic Bhargav Vemuri and 21 more Julie A. Reisz Angelo D’Alessandro Caterina Bartolacci Rafał Adamczak L. Ph. H. Schmidt Jiang Wang Amelia Martines Jahnavi Venkat Vanina Toffessi Tcheuyap Jacek Biesiada Catherine A. Behrmann Katherine E. Vest James Brugarolas Pier Paolo Scaglioni David R. Plas Krushna C. Patra Shuchi Gulati Julio A. Landero Figueroa Jarek Meller John T. Cunningham Maria Czyzyk-Krzeska

<p>Bulk RNA and spatial transcriptomics analysis of ccRCC.</p>

10.1158/2159-8290.28555215 preprint EN cc-by 2025-03-07
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