A5102011738- Epilepsy research and treatment
- Mechanisms of cancer metastasis
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Trace Elements in Health
- Cancer Mechanisms and Therapy
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Mental Health Research Topics
- RNA Research and Splicing
- Amino Acid Enzymes and Metabolism
- Diet and metabolism studies
- Peripheral Neuropathies and Disorders
- Ion channel regulation and function
- Schizophrenia research and treatment
- Ion Transport and Channel Regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Photocatalysis Techniques
- Glycogen Storage Diseases and Myoclonus
- EEG and Brain-Computer Interfaces
- Cancer, Hypoxia, and Metabolism
- Genomics and Rare Diseases
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Vagus Nerve Stimulation Research
Air Force Medical University
2015-2024
Xijing Hospital
2014-2024
Sun Yat-sen University
2024
Creative Commons
2019
Jiangsu University
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2009
University of Hong Kong
2003
Zero to Three
2003
The most severe form of brain glioma, glioblastoma (GBM), is highly malignant and usually resistant to chemotherapy. Therefore, discovery new targets for gene therapy important. Using subtraction cloning, we identified the human N-Myc downstream-regulated 2 (hNDRG2), located at chromosome 14q11.2, as a that significantly suppressed in GBM tissues. Semiquantitative RT-PCR showed hNDRG2 transcript expressed normal tissue low-grade gliomas but present low levels 15 27 (56%) tissues all 6 cell...
Lead is a heavy metal and important environmental toxicant nerve poison that can destruction many functions of the nervous system. poisoning medical condition caused by increased levels lead in body. interferes with variety body processes toxic to organs issues, including central It development system, therefore particularly children, causing potentially permanent neural cognitive impairments. In this study, we investigated relationship between intellectual neurobehavioral capabilities...
The NDRG2 gene belongs to a family of N-Myc downstream-regulated genes (NDRGs) and is expressed in many normal tissues. expression has been shown be regulated the stress response certain cells. However, its function not yet fully understood. Many studies have demonstrated that hypoxia, one responses, induced apoptosis several cell types. In current study, we investigated involvement hypoxia found was markedly up-regulated tumor lines exposed hypoxic conditions or similar stresses at mRNA...
MicroRNAs (miRNAs) exhibit tumor‐specific expression signatures and play crucial roles in tumorigenesis by targeting oncogenes. Here, through analyzing the miRNA‐array profiles of human glioblastoma tissues adjacent normal brain tissues, we found miR‐483–5p was significantly down‐regulated gliomas, which confirmed both glioma specimens cell lines. The overexpression suppressed proliferation induced a G0/G1 arrest. In contrast, inhibition promoted proliferation. Furthermore, dual‐luciferase...
The N-myc downstream-regulated gene 1 (ndrg1) is highly expressed in knock-out mice through an unknown regulatory mechanism. As one member of the human NDRG family, NDRG2 encodes a protein homologous to Ndrg1. However, it uncertain whether expression regulated by Myc because mouse ndrg2 and -3 are not affected Myc. In this study, we provide novel evidence that down-regulated via transcriptional repression. A high level was observed as reduced differentiated cells, whereas low shown following...
Summary Objective China has the largest population of patients with epilepsy worldwide, which imposes a heavy burden on public and health care systems. Several epidemiological surveys have been performed in China. Although these grossly describe prevalence gap treatment epilepsy, status centers is unclear. The number increased substantially recent decades. Therefore, nationwide investigation scale distribution, personnel, equipment, capacity each center great value. Methods In 2017–2018,...
Abstract Inflammatory responses in the brain are involved etiopathogenesis and sequelae of seizures. Ligation microglial CD40 plays a role development inflammatory central nervous system (CNS). Our study showed that there was an increased expression on activated microglia injury after lithium pilocarpine‐induced status epilepticus (SE) rats. Since peroxisome proliferator‐activated receptor gamma (PPARγ) acts as regulator CNS inflammation powerful pharmacological target for counteracting...
Abstract CELSR1 gene, encoding cadherin EGF LAG seven‐pass G‐type receptor 1, is mainly expressed in neural stem cells during the embryonic period. It plays an important role neurodevelopment. However, relationship between and disease of central nervous system has not been defined. In this study, we performed trios‐based whole‐exome sequencing a cohort 356 unrelated cases with partial epilepsy without acquired causes identified variants six cases. The included one de novo heterozygous...
Glioblastoma is a malignant primary brain tumor with poor prognosis median survival of only 12‑15 months. The high mortality rate this disease mainly due to the chemoresistance resulting from various reasons. Ubiquitin‑specific protease 4 (USP4) has recently been found be elevated in types cancer through regulating P53 activity. However, whether USP4 responsible for glioblastoma not clear. In present study, expression tissues and cell lines, as well its association temozolomide (TMZ) was...
Gastric cancer (GC) is a globally prevalent cancer, ranking fifth for incidence and fourth mortality worldwide. The N6-methyladenosine (m6A) related long noncoding RNAs (lncRNAs) were widely investigated in recent studies. Nevertheless, the underlying prognostic implication tumor immune mechanism of m6A-related lncRNA GC remain unknown.We systematically assessed m6A modification expression 407 clinical samples based on 23 regulators comprehensively associated these genes with lncRNAs. Then,...
Temporal lobe epilepsy (TLE) stands as the predominant adult focal syndrome, characterized by dysfunctional intrinsic brain dynamics. However, precise mechanisms underlying seizures in these patients remain elusive. Our study encompassed 116 TLE compared with 51 healthy controls. Employing microstate analysis, we assessed dynamic disparities between and controls, well drug-resistant (DRE) drug-sensitive (DSE) patients. We constructed functional connectivity networks based on microstates...