A5100400684- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Kidney Stones and Urolithiasis Treatments
- Colorectal Cancer Screening and Detection
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Lymphatic System and Diseases
- Economic and Financial Impacts of Cancer
- Atherosclerosis and Cardiovascular Diseases
- Cancer therapeutics and mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2025
Eye & ENT Hospital of Fudan University
2025
Cancer Hospital of Chinese Academy of Medical Sciences
2021-2024
Fujian Medical University
2014-2024
Fourth Hospital of Changsha
2024
Shenzhen Second People's Hospital
2023-2024
Shenzhen University Health Science Center
2023-2024
Fujian Provincial Hospital
2014-2024
Cancer Clinic
2024
Harbin Institute of Technology
2023
Oxaliplatin resistance can develop in colorectal cancer (CRC), which may involve inhibition of ferroptosis, although further research is needed to understand this potential mechanism. We evaluated CRC cells with acquired oxaliplatin (HCT116-Or) or congenital (H716) determine whether a ferroptosis inducer (RSL3) inhibitor (liproxstatin-1) could modulate the effects oxaliplatin. The results suggested that induction significantly reverse cells. Bioinformatic and cytobiological searches also...
Background— Postoperative atrial fibrillation is a frequent complication in cardiac surgery. The aberrant activation of signal transducer and activator transcription 3 (STAT3) contributes to the pathogenesis fibrillation. MicroRNA-21 (miR-21) promotes fibrosis. Recent studies support existence reciprocal regulation between STAT3 miR-21. Here, we test hypothesis that these 2 molecules might form feedback loop postoperative by promoting Methods Results— A sterile pericarditis model was created...
IntroductionVariable genomic breakpoints have been identified through the application of target-capture DNA next-generation sequencing (NGS) for ALK, ROS1, and RET fusion detection in NSCLC. We investigated whether breakpoint location can predict matched targeted therapy efficacy.MethodsNSCLCs were analyzed by NGS, target-specific RNA whole-transcriptome sequencing, immunohistochemistry.ResultsIn total, 3787 NSCLC samples analyzed. NGS detected fusions 241, 59, 76 cases, respectively. These...
Gastric cancer (GC) is one of the most common malignancies. Immunotherapy becomes an indispensable part GC. This study conducts bibliometric analysis immunotherapy for GC to clarify research status and identify potential new directions. VOS viewer CiteSpace visualization software were used demonstrate collaborations correlations. A total 1141 English publications from 2012 2022 included. The number increased year by year. mainly China (n = 579, 50.70%), followed United States. Fudan...
Abstract Background 5‐Fluorouracil (5‐FU) and capecitabine‐associated cardiotoxicity ranging from asymptomatic electrocardiography (ECG) abnormalities to severe myocardial infarction has been reported in a number of studies, but such Chinese patients with malignant diseases not investigated date. In the present study, we aimed prospectively evaluate incidence rates clinical manifestations 5‐FU‐ cancer recruited multiple centers China. Methods Among 527 who completed 196 received 5‐FU‐based...
There have been no comprehensive large-scale studies that evaluated the benefits of chemotherapy-based regimens in addressing HER2-altered advanced non-small-cell lung cancer (NSCLC) a first-line setting. Data on HER2 alteration subtypes and concomitant alterations are also limited. Accordingly, our retrospective, real-world POLISH study assesses efficacy chemotherapy alone (C) as well combinations with immune checkpoint inhibitors (C + I) or angiogenesis A) for NSCLC; molecular features...
Objective: To investigate the role of Ym2 in olfactory epithelium homeostasis and behavior. Methods: Differential expression young aged mice was analyzed using single-cell RNA sequencing. related genes were identified, their biological function by GO enrichment analysis. The Ym2-related detected immunostaining RNAscope situ hybridization. Buried food pullet test used to assess impact knockout on function, while evalute effect epithelium. Statistical analysis performed GraphPad Prism 8.0.1...
The Kirsten rat sarcoma viral oncogene (KRAS) is the most frequently mutated in human cancers. Significant advancements have been made targeted therapy and immunotherapy for this gene recent years, underscoring importance of comprehensively understanding genomic landscape KRAS across various cancer types. Using next-generation sequencing (NGS) technology a panel 520 genes, mutations, tumor mutation burden (TMB), microsatellite instability (MSI-H) status were investigated. An analysis 10,820...
Background Frailty is a common condition among patients with liver cirrhosis. Nonetheless, its role in predicting transplant-free survival (TFS) remains unclear. Aim This systematic review and meta-analysis were conducted to elucidate the relationship between frailty TFS Methods Cohort studies addressing objective of this extracted from PubMed, Embase, Web Science databases. Between-study heterogeneity was assessed Cochrane Q test, I^2 statistic estimated. Random-effect models, considering...
Abstract Background Diverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation sequencing (NGS), but the role exonic remains elusive. We investigated whether exonic-breakpoint could predict matched targeted therapy efficacy in non-small cell lung cancer (NSCLC). Methods NSCLC samples were analyzed NGS, RNA immunohistochemistry (IHC), and fluorescence situ hybridization. Results Using kinase 685 7148 (9.6%)...
Plaque rupture is a critical concern due to its potential for severe outcomes such as cerebral infarction and myocardial infarction, underscoring the urgency of noninvasive early diagnosis. Magnetic resonance imaging (MRI) has gained prominence in plaque imaging, leveraging noninvasiveness, high spatial resolution, lack ionizing radiation. Ultrasmall iron oxides, when modified with polyethylene glycol, exhibit prolonged blood circulation passive targeting toward sites, rendering them...
Abstract There has been a steady increase in the incidence of signet ring cell (SRC) carcinoma, distinct histological type with cells containing abundant intracytoplasmic mucin. We aimed to analyze clinicopathological characteristics and prognostic value patients SRC gastric cancer (GC) who underwent gastrectomy. Clinical data 10,312 GC D2 radical gastrectomy were obtained from Surveillance, Epidemiology, End Results database retrospectively analyzed. X-tile plots constructed illustrate...
To examine lymphatic microvessel density (LMVD) in primary pterygia.We included tissue samples from 88 excised (including 34 grade 1, 28 2, and 26 3) pterygia 7 nasal epibulbar conjunctivae segments used as control samples. Sections each pterygium were immunostained with CD31 vessel endothelial hyaluronan receptor 1 (LYVE-1) monoclonal antibodies to evaluate LMVD blood density. We real-time polymerase chain reaction analysis measure expression of vascular growth factor A (VEGF-A) VEGF-C...
Abstract Background ROS1 gene fusion represents a specific subtype of non‐small cell lung cancer (NSCLC). Crizotinib is recommended for ROS1‐ positive NSCLC due to its favorable outcome in published clinical trials. However, the low incidence NSCLC, there limited information on real‐world outcomes patients treated with either crizotinib or platinum‐based doublet chemotherapy. Methods Outcomes were recorded 102 stage Ⅲb Ⅳ who at four Chinese hospitals between April, 2010 and June, 2019....
Purpose: To investigate the effect of tacrolimus in alkali burn-induced corneal neovascularization (NV) and inflammation to compare with anti-vascular endothelial growth factor (anti-VEGF). Methods: After alkali-burn, 84 Wistar rats were randomly divided into three groups received either saline solution or 0.05% (0.5 mg/mL) four times daily, subconjunctival anti-VEGF injection mg/0.05 mL). Corneal NV, opacity epithelial defects, status inflammation, levels proinflammatory angiogenic...
Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) predisposition syndrome. We performed a large-scale study to assess screening strategy for identifying LS in Chinese CRC patients routine clinical testing. A total of 4,195 eligible CRCs were universally screened. Then, 8.7% detected with dMMR. The incidence was 2.7% (115 4,195) this cohort; among over 70 years age, only 0.3% (2 678) diagnosed as LS. 17.4% cases showed large genomic deletions/duplications. probands...
The uncommon p.L747P mutation in epidermal growth factor receptor (EGFR) exon 19 reveals to alter the response tyrosine kinase inhibitors (TKIs) patients diagnosed with advanced non-small cell lung cancer (NSCLC). However, underlying mechanism is still not clear. This study aimed investigate clinical outcomes, binding affinities, and modes of action currently available EGFR TKIs towards mutation.Clinical data NSCLC harboring who had received different generations were collected from medical...
Histidine triad nucleotide-binding 2 (HINT2), a member of the histidine proteins family, sensitizes cells to apoptosis in hepatocellular carcinoma. Here, we showed that HINT2 expression is lower primary colorectal cancer (CRC) and metastasis tissues than normal tissues, abundance inversely correlated with CRC tumor stage. Treating 5-aza-2'-deoxycytidine, demethylating agent, upregulated HINT2, suggesting downregulation caused by methylation gene promoter. increased migration invasion vitro,...