A5042479118- Immune Cell Function and Interaction
- Immune cells in cancer
- COVID-19 Impact on Reproduction
- Single-cell and spatial transcriptomics
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Genetic and phenotypic traits in livestock
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
State Key Laboratory of Respiratory Disease
2019-2021
Guangzhou Medical University
2019-2021
Henan University
2020-2021
Kunming Institute of Zoology
2016
Chinese Academy of Sciences
2016
Abstract Profiling heterologous cell types within tumors is essential to decipher tumor microenvironment that shapes progress and determines the outcome of therapeutic response. Here, we comprehensively characterized transcriptomes 34,037 single cells obtained from 12 treatment‐naïve patients with colorectal cancer. Our comprehensive evaluation revealed attenuated B‐cell antigen presentation, distinct regulatory T‐cell clusters different origin novel polyfunctional associated macrophages...
Knowledge of immune cell phenotypes, function, and developmental trajectory in acute myeloid leukemia (AML) microenvironment is essential for understanding mechanisms evading surveillance immunotherapy response targeting special components.Using a single-cell RNA sequencing (scRNA-seq) dataset, we analyzed the bone marrow (BM) samples from 16 AML patients 4 healthy donors, but not blasts.We observed significant difference between normal BM cells. Here, defined diversity dendritic cells (DC)...
Morbidity and mortality of coronavirus disease 2019 (COVID-19) is age-dependent. It remains unclear whether vertical severe acute respiratory syndrome 2 (SARS-CoV-2) occurs during pregnancy how such infection will affect fetal development. Here, we performed single-cell transcriptomic analysis placenta other tissues from fetuses in comparison with those adults using public-available datasets. Our revealed that a very small proportion trophoblast cells expressed the Angiotensin I Converting...
Dendritic cells (DCs) play pivotal roles in T-cell homeostasis and activation, metabolic programing has been recently linked to DC development function. However, the underpinnings corresponding distinct functions remain largely unresolved. Here, we demonstrate a special metabolic–epigenetic coupling mechanism orchestrated by tuberous sclerosis complex subunit 1 (TSC1)-mechanistic target of rapamycin (mTOR) for homeostatic Specific ablation Tsc1 compartment (Tsc1DC-KO) preserved but led...
A common phenotypic difference among domestic animals is variation in coat color. Six-white-point a pigmentation pattern observed varying pig breeds, which seems to have evolved through several different mechanistic pathways. Herein, we re-sequenced whole genomes of 31 Diannan small-ear pigs from China and found that the six-white-point color likely regulated by polygenic loci, rather than MC1R locus. Strong associations were at three loci (EDNRB, CNTLN, PINK1), explain about 20 percent...
Background: The morbility and mortality of patients with coronavirus disease 2019 (COVID-19) is associated age. However, it remains mysterious what factors influence the immunity to infection determine outcome. Methods: Here we have comprehensively investigated clinical features 186 cases including 25 pediatric under ten years old analyzed that their outcomes. Findings: Although severity COVID-19 was age, found even in children regardless In contrast adults, mainly had mild symptoms did not...