A5100638521- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Cancer Genomics and Diagnostics
- COVID-19 Digital Contact Tracing
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Mobile Crowdsensing and Crowdsourcing
- Structural Health Monitoring Techniques
- Lung Cancer Treatments and Mutations
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Machine Learning in Healthcare
- Vascular anomalies and interventions
- Advanced Measurement and Detection Methods
- Renal and Vascular Pathologies
- Sensor Technology and Measurement Systems
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Ultrasonics and Acoustic Wave Propagation
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Congenital limb and hand anomalies
Shanghai Institute of Nutrition and Health
2021-2024
University of Chinese Academy of Sciences
2022-2024
Zhejiang University
2023
Second Affiliated Hospital of Zhejiang University
2022-2023
Chongqing Medical University
2023
Lanzhou University
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
State Key Laboratory of Biotherapy
2022
Sichuan University
2022
Chinese Academy of Sciences
2021
Microglia continuously survey the brain parenchyma and actively shift status following stimulation. These processes demand a unique bioenergetic programme; however, little is known about metabolic determinants in microglia. By mining large datasets generating transgenic tools, here we show that hexokinase 2 (HK2), most active isozyme associated with mitochondrial membrane, selectively expressed microglia brain. Genetic ablation of HK2 reduced microglial glycolytic flux energy production,...
Ferroptosis is implicated in a range of brain disorders, but it unknown whether neurons or glia the are particularly effected. Here, we report that primary cortical astrocytes (PA), microglia (PM), and (PN) varied their sensitivities to ferroptosis. Specifically, PM were most sensitive ferroptosis, while PN relatively insensitive. In contrast, equally susceptible apoptosis, with PA being less affected, whereas all three cell types similarly autophagic death. tri-culture system containing PA,...
Central precocious puberty (CPP), largely caused by germline mutations in the MKRN3 gene, has been epidemiologically linked to cancers. is frequently mutated non–small cell lung cancers (NSCLCs) with five cohorts. Genomic aberrations are significantly enriched NSCLC samples harboring oncogenic KRAS mutations. Low expression levels correlate poor patient survival. Reconstitution of MKRN3-inactivated cells directly abrogates vitro and vivo tumor growth proliferation. knockout mice susceptible...
Objective. This study focuses on the identification of risk factors, classification stroke level, and evaluation importance interactions various patient characteristics using cohort data from Second Hospital Lanzhou University. Methodology. Risk factors are identified by relationships between response, as well ranking characteristics. Then, after discarding negligible some well-known multicategorical algorithms used to predict level stroke. In addition, Shapley additive explanation method...
Background Cancer immunotherapies can induce durable tumor regression, but most patients do not respond. SETD2 mutation has been linked to the efficacy of immune checkpoint inhibitors (ICIs) immunotherapy. The functional importance inactivation and how modulate immunotherapy response remains unclear. Methods To explore function in immunotherapy, knockout subsequent experiments were conducted. Bulk RNA-seq, ATAC-seq, Chip-seq single-cell RNA-seq performed dissect mechanism microenvironment...
In this paper, we propose a new privacy-preserving, automated contact tracing system, ACOUSTIC-TURF, to fight COVID-19 using acoustic signals sent from ubiquitous mobile devices. At high level, ACOUSTIC-TURF adaptively broadcasts inaudible ultrasonic with randomly generated IDs in the vicinity. Simultaneously, system receives other nearby (e.g., 6 feet) users. such individual user are not disclosed others and can accurately detect encounters physical proximity 6-foot granularity. We have...
Instead of acquiring the previous aberrations an optical wavefront with a sensor, sensor-less (WFSless) adaptive optics (AO) systems compensate for distortion by optimizing performance metric directly. The stochastic parallel gradient descent (SPGD) algorithm is pervasively adopted to achieve optimization. In this work, we incorporate CoolMomentum, method optimization Langevin dynamics simulated annealing, into SPGD. Numerical simulations reveal that, compared state-of-the-art SPGD variant,...
Abstract In response to the risk of settling in long-term storage viscoelastic fuel aircraft solid engines, this study proposes a fuel-settling monitoring system based on cooperation implanted optical fibers and wireless passive sensors for first time. The does not require wiring holes original structure engine, avoiding unpredictable damage structure. At same time, elastic modulus settlement sensor is similar that fuel, overcoming problem measurement uncertainty caused by mismatch...
Triphalangeal thumb-polysyndactyly syndrome (TPTPS) is an autosomal dominant limb disorder with triphalangeal thumbs, polysyndactyly, and syndactyly.In this study, we describe a fourgeneration Han Chinese family eight affected members.Haplotype analysis, Affymetrix SNP 6.0 arrays, qPCR, gap-PCR were performed.Haplotyping results linked the disease-causing region to 7q36 that includes zone of polarizing activity-regulatory sequence.A 442-kb duplication was found on chromosome 7 cosegregated...
Superior mesenteric artery syndrome (SMAS) is a rare medical condition resulting from vascular compression of the third part duodenum in angle between aorta and superior artery, leading to partial or complete intestinal obstruction causing series symptoms. We now introduce case SMAS after lung cancer surgery, which was unique that it most likely caused by weight loss surgery.A 58-year-old male patient gradually developed severe nausea, vomiting, surgery. A diagnosis made computed tomography...
As a critical structure of aerospace equipment, aluminum alloy stiffened plate will influence the stability spacecraft in orbit and normal operation system. In this study, GWO-ELM algorithm-based impact damage identification method is proposed for panels to monitor evaluate condition such spacecraft. Firstly, together with numerical simulation, experimental simulation obtain acoustic emission signals reinforced performed, establish data. Subsequently, amplitude-frequency characteristics are...