A5100418957- Plant tissue culture and regeneration
- Nuclear Physics and Applications
- Plant Water Relations and Carbon Dynamics
- Land Use and Ecosystem Services
- Plant and Fungal Species Descriptions
- Sarcoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Remote Sensing and Land Use
- Soil Carbon and Nitrogen Dynamics
- Biopolymer Synthesis and Applications
- Coral and Marine Ecosystems Studies
- Nanocluster Synthesis and Applications
- Environmental Changes in China
- Nuclear Materials and Properties
- Cryospheric studies and observations
- Methane Hydrates and Related Phenomena
- Forest, Soil, and Plant Ecology in China
- Coastal and Marine Management
- Advanced Photocatalysis Techniques
- Climate variability and models
- Inflammasome and immune disorders
- Video Coding and Compression Technologies
- Cancer Genomics and Diagnostics
- Plant Parasitism and Resistance
- Remote Sensing in Agriculture
University of Science and Technology of China
2024-2025
China University of Geosciences (Beijing)
2025
Chinese Academy of Sciences
2008-2024
Beijing Institute of Big Data Research
2024
Aerospace Information Research Institute
2024
West Anhui University
2024
Hefei Institutes of Physical Science
2024
Ningbo University
2023
Hainan Medical University
2023
Sichuan Agricultural University
2023
Proton computed tomography (pCT) has the potential to improve accuracy of dose calculations for proton treatment planning, and will also be useful pretreatment verification patient positioning relative beam. A design study was performed define optimal approach a pCT system based on specifications applications in therapy. Conceptual detailed is presented; consists silicon-based particle tracking crystal calorimeter measure energy loss individual protons. We discuss formation images...
Carbon quantum dots (CDs) are promising nanomaterials in biomedical, photocatalytical and photoelectronic applications. However, determining how to explore an ideal precursor for a renewable carbon resource is still interesting challenge. Here, the first time, we report that wastes of bagasse as new were prepared fluorescent CDs by hydrothermal carbonization (HTC) process. The characterization results show such bagasse-derived monodispersed, contain quasi spherical particles with diameter...
The balance between ecosystem service supply–demand and landscape ecological risk are two crucial aspects influencing the sustainable development of regional ecosystems. Current evaluations ignore these lead to partial planning in urban areas. As a result, framework was built for areas based on multidimensional ecosystems high-efficiency land use planning. First, determine scale, supply demand five services were quantified—biodiversity conservation, carbon sequestration, water food...
Abstract. The Tibetan Plateau has a significant role with regard to atmospheric circulation and the monsoon in particular. Changes between closed plant cover open bare soil are one of striking effects land use degradation observed unsustainable range management or climate change, but experiments investigating changes surface properties processes together feedbacks rare have not been undertaken world's two largest alpine ecosystems, steppe Kobresia pygmaea pastures Plateau. We connected...
X-ray computed tomography (CT) is the most commonly used imaging technique for noninvasive diagnosis of disease. In order to improve tissue specificity and prevent adverse effects, we report design synthesis iodine-doped carbon dots (I-doped CDs) as efficient CT contrast agents fluorescence probe by a facile bottom-up hydrothermal carbonization process. The as-prepared I-doped CDs are monodispersed spherical nanoparticles (a diameter ~2.7 nm) with favorable dispersibility colloidal stability...
Predicting peptide binding affinity with human leukocyte antigen (HLA) is a crucial step in developing powerful antitumor vaccine for cancer immunotherapy. Currently available methods work quite well predicting HLA alleles such as HLA-A*0201, HLA-A*0101, and HLA-B*0702 terms of sensitivity specificity. However, few types that are present the majority populations including HLA-A*0202, HLA-A*0203, HLA-A*6802, HLA-B*5101, HLA-B*5301, HLA-B*5401, HLA-B*5701 still cannot be predicted satisfactory...
Target 14 of the Sustainable Development Goals (SDG 14) depicts a better future regarding capacity coastal environments to cope with several developmental challenges. However, gaps in data and indicators restrict effective implementation this global plan. In context, under umbrella Digital Belt Road (DBAR) Program, DBAR_COAST working group (WG) aims solve problems sustainable development along Maritime Silk (MSR). This paper demonstrates recent efforts WG develop based on Earth observation...
Naoxintong (NXT) is a Chinese Materia Medica standardized product extracted from 16 various kinds of traditional herbal medicines including Salvia miltiorrhiza, Angelica sinensis, Astragali Radix. clinically effective in treating ischaemia heart disease. Nucleotide-binding oligomerization domain-Like Receptor with Pyrin domain 3 (NLRP3) inflammasome has been critically involved myocardial ischaemia/reperfusion (I/R) injury. Here, we have suggested that NXT might attenuate I/R injury via...
Central precocious puberty (CPP), largely caused by germline mutations in the MKRN3 gene, has been epidemiologically linked to cancers. is frequently mutated non–small cell lung cancers (NSCLCs) with five cohorts. Genomic aberrations are significantly enriched NSCLC samples harboring oncogenic KRAS mutations. Low expression levels correlate poor patient survival. Reconstitution of MKRN3-inactivated cells directly abrogates vitro and vivo tumor growth proliferation. knockout mice susceptible...
Abstract Objective Our study was designed to explore the role of IL‐37 in M1/M2 macrophage polarization imbalance pathogenesis periodontitis. Background Periodontitis is a chronic progressive inflammatory disease featured by gingival inflammation and alveolar bone resorption. Recent research has revealed that regulating viable method ameliorate periodontal inflammation. an anti‐inflammatory cytokine, which been reported inhibit innate adaptive immunity. Methods For vitro experiment, mouse...
Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and initiated by activating mutations in KIT or PDGFRA receptor tyrosine kinases. Chromosome 22q deletions well-recognized frequent abnormalities GISTs, occurring ∼50% of GISTs. These thought to contribute pathogenesis this disease via currently unidentified tumor suppressor mechanisms. Using whole exome sequencing, we report recurrent genomic inactivated DEPDC5 gene GISTs (16.4%, 9 55 patients). The demonstration...
Objectives: The tumor microenvironment (TME) plays a critical role in progression and therapeutic response. We aimed to establish TME-associated gene signature for lung adenocarcinoma (LUAD) patients. Materials Methods: comprehensively analyzed the expression data of 513 LUAD patients deriving from Cancer Genome Atlas (TCGA) database. To estimate composition TME, Estimation Stromal Immune cells malignant tissue using Expression (ESTIMATE) algorithm was used. then utilized protein-protein...
Abstract Background: KRAS is one of the most common mutated oncogenes in cancer, which primarily stimulates tumor growth by activating MAPK pathway. Tumors with non-KRASG12C mutations, such as KRASG12D, KRASG12V, and other codon mutation subtypes, currently lack compelling precision medicines. Therefore, development pan-KRAS inhibitor an unmet pressing clinical need. Methods Results: Here, we report a novel, orally bioavailable (ON) HJ-099, designed to treat various mutation-driven tumors....
Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear receptors (ER), and altering ER related protein expressions. With the GEO database analysis, Human centromere F (CENPF) is highly expressed in adenocarcinoma (LUAD), co-expression of CENPF ERβ was found nucleus LUAD cells through immunofluorescence. We identified explored its relationship with pathway. ERβ2/5 were T stage poor prognosis (P<0.05). knockout significantly inhibited cell growth, tumor growth...
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with few therapeutic options, representing one of the great challenges in oncology. Activating KRAS mutation, occurring >90% PDACs, present pancreatic intraepithelial neoplasia lesions, precursor lesions PDAC, indicating additional genetic alterations contribute to pathogenesis PDAC. PDAC sequencing projects identify recurrent genomic ERBB2 alterations, mutations and amplifications, 8.5% patients, ranking as top hit among 100...
IFL (Image Forgery Location) helps secure digital media forensics. However, many methods suffer from false detections (i.e., FPs) and inaccurate boundaries. In this paper, we proposed the CatmullRom Splines-based Regression Network (CSR-Net), which first rethinks task perspective of regression to deal with problem. Specifically speaking, propose an adaptive CutmullRom splines fitting scheme for coarse localization tampered regions. Then, positive cases, develop a novel re-scoring mechanism,...
Abstract. The Tibetan Plateau has a significant role with regard to atmospheric circulation and the monsoon in particular. Changes between closed plant cover open bare soil are one of striking effects land use degradation observed unsustainable range management or climate change, but experiments coupling changes surface properties processes feedbacks rare have not been undertaken world's two largest alpine ecosystems, steppe Kobresia pygmaea pastures plateau. We coupled measurements...
A thick natural lead target has been bombarded with a 600 MeV ${}^{18}\mathrm{O}$ beam. With the use of an online gas-thermochromatographic device mercury isotopes produced as residues were rapidly separated and collected. special coincident measurement technique increased sensitivity to detecting ${\ensuremath{\beta}}^{\ensuremath{-}}$-delayed $\ensuremath{\gamma}$ rays, resulting in observation six neutron-rich ${}^{203,205--209}\mathrm{Hg}$. Here ${}^{209}\mathrm{Hg}$ was created through...