A5036576535- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- Nanocluster Synthesis and Applications
- Cancer-related molecular mechanisms research
- Conducting polymers and applications
- Lung Cancer Diagnosis and Treatment
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Perovskite Materials and Applications
- Mesenchymal stem cell research
- Semiconductor materials and interfaces
- Osteoarthritis Treatment and Mechanisms
- Spinal Cord Injury Research
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
Jiangsu University
2014-2025
Affiliated Hospital of Jiangsu University
2014-2025
National Yang Ming Chiao Tung University
1987-2024
Central People's Hospital of Zhanjiang
2017-2024
Anhui University
2024
Hefei Institutes of Physical Science
2024
Fujian Medical University
2012-2023
Wuhan University
2023
Southwest University
2023
National Cheng Kung University
2023
Purpose: The primary goal of the present study was to develop nano-drug consisting doxorubicin and exosome derived from mesenchymal stem cells, explore its effect on osteosarcoma in vitro. Methods: exosomes were isolated bone marrow MSCs (BM-MSCs) by an Exosome Isolation Kit. exosome-loaded (Exo-Dox) prepared mixing with Dox-HCl, desalinizing triethylamine then dialyzing against PBS overnight. nanoparticle tracking analysis (NTA) transmission electron microscope (TEM) used characterize...
This trial aimed to assess the efficacy and safety of paclitaxel plus fluorouracil regimen versus cisplatin in definitive concurrent chemoradiotherapy (dCRT) patients with locally advanced esophageal squamous cell carcinoma (ESCC).Patients ESCC were enrolled randomly assigned either group or group. The treated one cycle per week dCRT for five cycles followed by month consolidation chemotherapy two cycles. cisplatin/5-fluorouracil chemotherapy. radiotherapy dose was 61.2 Gy delivered 34...
The inherent radioresistance and inaccuracy of localization tumors weaken the clinical implementation effectiveness radiotherapy. To overcome these limitations, hyaluronic acid-functionalized bismuth oxide nanoparticles (HA-Bi2O3 NPs) were synthesized by one-pot hydrothermal method for target-specific computed tomography (CT) imaging radiosensitization tumor. After functionalization with acid, Bi2O3 NPs possessed favorable solubility in water excellent biocompatibility uptaken specifically...
The objective of this study was to investigate the antitumor activity, targeting capability, and mechanism developed nanodrug consisting doxorubicin exosome (Exo-Dox) derived from mesenchymal stem cells in vitro vivo. exosomes were isolated with Exosome Isolation Kit, Exo-Dox prepared by mixing Dox-HCl, desalinizing triethylamine then dialyzing against PBS overnight. examined nanoparticle tracking analysis (NTA) transmission electron microscopy (TEM). evaluated cell viability assay,...
Abstract 2D Ruddlesden–Popper perovskites are highly regarded materials for improving the stability of perovskite solar cells (PSCs). Wherein, self‐additive have recently been proposed to provide substantial strategies managing crystallization kinetics and bulk defects. For a profound understanding formation mechanisms, herein, with selecting three as demonstrations, comprehensive analysis behavior combing experimental theoretical calculations is conducted. Self‐additive exhibit more...
X-ray computed tomography (CT) is the most commonly used imaging technique for noninvasive diagnosis of disease. In order to improve tissue specificity and prevent adverse effects, we report design synthesis iodine-doped carbon dots (I-doped CDs) as efficient CT contrast agents fluorescence probe by a facile bottom-up hydrothermal carbonization process. The as-prepared I-doped CDs are monodispersed spherical nanoparticles (a diameter ~2.7 nm) with favorable dispersibility colloidal stability...
Abstract Epigenetic abnormalities play a vital role in the progression of ovarian cancer. Lysine-specific demethylase 1 (LSD1/KDM1A) acts as an epigenetic regulator and is overexpressed tumors. However, upstream LSD1 expression this cancer remains elusive. Here, we show that epidermal growth factor (EGF) signaling upregulates protein levels SKOV3 HO8910 cells overexpressing both EGF receptor. This effect correlated with decrease dimethylation H3K4, major substrate LSD1, LSD1-dependent...
Macrophages are a type of immune cell that helps eliminate pathogens and diseased cells. Recent research has shown macrophages can sense mechanical cues from potential targets to perform effective phagocytosis, but the mechanisms behind it remain unclear. In this study, we used DNA-based tension probes study role integrin-mediated forces in FcγR-mediated phagocytosis. The results showed when phagocytic receptor FcγR is activated, force-bearing integrins create "mechanical barrier" physically...
Decreasing oocyte competence with maternal aging is a major factor in mammalian infertility. One of the factors contributing to this infertility changes chromatin modifications, such as histone acetylation old MII stage oocytes. Recent studies indicate that at arise germinal vesicle (GV) stage. We hypothesised methylation could also change GV To test hypothesis, we examined mono-, di- and trimethylation H3 lysine 4 (H3K4 me1, me2 me3, respectively) young older oocytes from 6-8-...
Esophageal cancer is a highly invasive malignancy. Neoadjuvant chemoradiotherapy not only increases the rate of complete resection but also improves median survival. However, sensitive biomarker urgently needed in clinical practice. 60 esophageal squamous cell carcinoma (ESCC) patients undergoing neoadjuvant (NCRT) were enrolled at People's Hospital Affiliated to Jiangsu University. Patients grouped according tumor regression grade (TRG) criteria from College American Pathologists (CAP). The...
Abstract Purpose: Preclinical model found that elective nodal irradiation (ENI) attenuated the efficacy of radiotherapy and radio-immunotherapy. However, limited clinical studies have explored correlation between radiation dose-volume parameters negative tumor draining lymph nodes (TDLNs) T-cell activation/prognosis for cancer patients treated with definitive radio(chemo)therapy. Experimental Design: Patients locally advanced esophageal undergoing chemoradiotherapy (CRT) were selected from...
<div>AbstractPurpose:<p>A preclinical model found that elective nodal irradiation attenuated the efficacy of radiotherapy (RT) and radio-immunotherapy. However, limited clinical studies have explored correlation between radiation dose–volume parameters negative tumor-draining lymph nodes (TDLN) T-cell activation/prognosis for patients with cancer treated definitive radiochemotherapy.</p>Experimental Design:<p>Patients locally advanced esophageal undergoing...
<p>Supplementary Figures</p>
Abstract Although perovskite solar cells (PSCs) demonstrate outstanding power conversion efficiency (PCE), their practical applications are still limited by stability issues caused various problems such as poor crystal quality triggered structural instability. Herein, to address the instability of perovskites, we introduced a polymer additive, poly-L-lysine hydrobromide (PLL), into precursor promote growth, thereby constructing stable structure. The results show that introduction PLL...
The death-associated protein kinase 1 (DAPK1) gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 has been found in many carcinomas. epigenetic changes TSGs are now recognized as mechanism contributing to development chronic myeloid leukemia (CML). To clarify role CML, we examined status 49 patients with CML using methylation-specific polymerase chain reaction. aberrant was 25 (51.0%) cases, not all controls. No correlation between age, hematologic parameters,...