A5100343543- Ubiquitin and proteasome pathways
- interferon and immune responses
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Pluripotent Stem Cells Research
- Sarcoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- RNA regulation and disease
- Enzyme Catalysis and Immobilization
- Inflammasome and immune disorders
- Diverse Approaches in Healthcare and Education Studies
- Aging, Elder Care, and Social Issues
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Anesthesia and Neurotoxicity Research
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Health, Medicine and Society
- Education and Learning Interventions
- Virtual Reality Applications and Impacts
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Rheumatoid Arthritis Research and Therapies
- Consumer Perception and Purchasing Behavior
- Mitochondrial Function and Pathology
Shanghai Institute of Nutrition and Health
2019-2024
Fujian Normal University
2019-2024
Inner Mongolia Normal University
2024
Qingdao Institute of Bioenergy and Bioprocess Technology
2024
Chinese Academy of Sciences
2017-2024
University of Chinese Academy of Sciences
2024
Hainan Medical University
2024
Hainan General Hospital
2024
Qinghai New Energy (China)
2024
Southern Medical University
2019-2022
Central precocious puberty (CPP), largely caused by germline mutations in the MKRN3 gene, has been epidemiologically linked to cancers. is frequently mutated non–small cell lung cancers (NSCLCs) with five cohorts. Genomic aberrations are significantly enriched NSCLC samples harboring oncogenic KRAS mutations. Low expression levels correlate poor patient survival. Reconstitution of MKRN3-inactivated cells directly abrogates vitro and vivo tumor growth proliferation. knockout mice susceptible...
Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and initiated by activating mutations in KIT or PDGFRA receptor tyrosine kinases. Chromosome 22q deletions well-recognized frequent abnormalities GISTs, occurring ∼50% of GISTs. These thought to contribute pathogenesis this disease via currently unidentified tumor suppressor mechanisms. Using whole exome sequencing, we report recurrent genomic inactivated DEPDC5 gene GISTs (16.4%, 9 55 patients). The demonstration...
Gastrointestinal stromal tumor (GISTs) are clinically heterogenous exhibiting varying degrees of disease aggressiveness in individual patients. We comprehensively describe the genomic and transcriptomic landscape a cohort 117 GISTs including 31 low-risk, 18 intermediate-risk, 29 high-risk, 34 metastatic 5 neoadjuvant from 105 have notably low mutation burden but widespread copy number variations. Aggressive harbor remarkably more aberrations than low-/intermediate-risk GISTs. Complex...
Pyroptosis is a proinflammatory programmed cell death pathway mediated by gasdermins. Exploring the role of pyroptosis can provide new insights into tumor malignancy. The most recent studies on have focused cells. However, effects microenvironment (TME), immunotherapeutic responses, and efficacy been neglected, especially in case glioma. In this study, four independent glioma cohorts comprising 1,339 samples pan-cancer cohort 10,535 were analyzed. relationships among status, prognosis,...
Death Associated Protein Kinase 1 (DAPK1) is an important signaling kinase mediating the biological effect of multiple natural biomolecules such as IFN-γ, TNF-α, curcumin, etc. DAPK1 degraded through both ubiquitin-proteasomal and lysosomal degradation pathways. To investigate crosstalk between these two pathways, we carried out a screen using set ubiquitin E2 siRNAs at presence Tuberous Sclerous 2 (TSC2) identified that small ubiquitin-like molecule (SUMO) pathway able to regulate protein...
Glioblastoma (GBM) is the most malignant and aggressive glioma, which has a very poor prognosis. Temozolomide (TMZ) still first‐line treatment, but resistance inevitable even in MGMT‐deficient glioblastoma cells. The aims of this study were to comprehend effect TMZ on nucleus underlying mechanism acquired GBM. We show changes nuclear proteome GBM U87 cells treated with for 1 week. Label‐free–based quantitative proteomics used investigate protein abundance change. Subsequently, gene ontology...
Fibroblasts can be transdifferentiated directly into other somatic cells such as cardiomyocytes, hematopoietic cells, and neurons. An advantage of cell differentiation without first generating induced pluripotent stem (iPSCs) is that it avoids contamination the differentiated with residual iPSCs, which may cause teratoma. However, since primary fibroblasts from biopsy undergo senescence during repeated culture, difficult to grow in sufficient numbers for future therapeutic purposes. To...
2-Phenylethanol (2-PE) and indole-3-acetic acid (IAA) are important secondary metabolites produced by microorganisms, their production closely linked to the growth state of microorganisms environmental factors. Enterobacter CGMCC 5087 can produce both 2-PE IAA depending on α-ketoacid decarboxylase KDC4427. This study aimed investigate effects different environment factors including osmotic pressure, temperature, pH synthesis in sp. 5087. The bacteria exhibited an enhanced capacity for while...
With the rapid development of Artificial Intelligence (AI) technology, its application in creative industry, especially field animation, is continuously increasing. Generated Content (AIGC) technology revolutionizing traditional production process, introducing new methods creation. AIGC, integrating technologies such as computer vision, natural language processing, and generative adversarial networks, assists character design, scene construction, script writing. This integration not only...
Synovial inflammation is vital for the progression of osteoarthritis (OA). The objective this study was to explore effects and potential molecular mechanisms sphingosine kinase 2 (SPHK2) on proliferation migration fibroblast-like synoviocytes (FLS).
We have previously found that the DAPK-DDX20 signaling axis exerts an anti-cancer activity in hepatocellular carcinoma (HCC) by inhibiting GTPase of CDC42, thereby reducing invasive and migratory capabilities cancer cells without affecting cell proliferation. DDX20 serves as intermediate protein regulated DAPK control CDC42. Specifically, enhances levels suppressing degradation. However, mechanism underlying regulation remains unclear. In current study, we discovered is degraded through...
Virtual Reality (VR) is increasingly integrated with other industries since the 20th century, and VR frequently applied in teaching. VR-based immersive virtual experiments provide a new possibility for teaching of physics colleges. In this case, experiment platform was designed to guide standardize experimental procedure process. Meanwhile, offered experimenters nearly real laboratory scene, by which expense sites test equipment significantly reduced. The data showed that highly pragmatic...