A5101946715- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Circular RNAs in diseases
- Ion channel regulation and function
- Ion Transport and Channel Regulation
- Cancer Mechanisms and Therapy
- Neurofibromatosis and Schwannoma Cases
- Rough Sets and Fuzzy Logic
- Electronic Health Records Systems
- Epigenetics and DNA Methylation
- Topic Modeling
- Lymphoma Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Biomedical Text Mining and Ontologies
- Immune Cell Function and Interaction
- Data Mining Algorithms and Applications
- Non-Invasive Vital Sign Monitoring
- Electrochemical Analysis and Applications
- Educational Innovations and Challenges
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2011-2025
Suizhou Central Hospital
2025
Mianyang Third People's Hospital
2025
Peking University
2024
Second People Hospital of Hunan
2024
Hunan University of Traditional Chinese Medicine
2024
Central South University
2023
Ministry of Education of the People's Republic of China
2023
Harbin Medical University
2023
As a newly identified and characterized gene, p42.3 is associated with cell proliferation tumorigenicity. The expression of upregulated in human gastric cancer (GC), but its underlying mechanisms action are not well understood. MicroRNAs (miRNAs) known to play vital regulatory roles many cellular processes. Here we utilized bioinformatics experimental approaches investigate the relationship between miRNAs gene. We showed that miR-29a could repress at both mRNA protein levels via directly...
The gene, collagen triple helix repeat containing 1 (CTHRC1), has been reported to increase in several kinds of human solid cancers and is associated with tumor invasion metastasis. To date, the expression function CTHRC1 gastric cancer (GC) have not reported. aim this study was investigate levels regulatory transcription mechanisms GC. Immunohistochemical analysis revealed that markedly increased carcinoma compared normal mucosa, chronic atrophic gastritis, intestinal metaplasia (P < 0.05...
Abstract Purpose Liver metastasis, a lethal malignancy of gastric cancer (GC) patients, execrably impairs their prognosis. As yet, however, few studies have been designed to identify the driving molecules during its formation, except screening evidence pausing before functions or mechanisms. Here, we aimed survey key event within invasive margin liver metastases. Methods A metastatic GC tissue microarray was used for exploring malignant events liver-metastasis followed by assessing...
The acid-sensing ion channel 1 (ASIC1) is a key receptor for extracellular protons. Although numerous structural and functional studies have been performed on this channel, the dynamics underlying gating mechanism remains unknown. We used normal mode analysis, mutagenesis, electrophysiological methods to explore relationship between inherent of ASIC1 its mechanism. Here we show that series collective motions among domains subdomains correlate with function. analysis result reveals intrinsic...
Acid-sensing ion channels (ASICs), which belong to the epithelial sodium channel/degenerin family, are activated by extracellular protons and inhibited amiloride (AMI), an important pharmacological tool for studying all known members of channel/degenerin. In this study, we reported that AMI paradoxically opened homomeric ASIC3 heteromeric plus ASIC1b at neutral pH synergistically enhanced channel activation induced mild acidosis (pH 7.2 6.8). The characteristic profile stimulation was...
MicroRNAs (miRNAs) are small non‑coding RNA molecules that regulate the expression of targeted genes in a post‑transcriptional manner. Increasing evidence indicates miRNAs play important roles cancer pathogenesis, including apoptosis, proliferation and differentiation, as oncogenes or tumor suppressors. Previously, miR‑375 was shown to be involved human gastric cancer, however, mechanism remains poorly understood. In present study, downregulated tissues, particularly epidermal growth factor...
Gastric cancer is associated with significant morbidity and mortality in the world. Blocking programmed cell death protein 1 pathway have been approved for treatment of a variety tumors achieved remarkable clinical therapeutic effects. However, immune checkpoint inhibitors failed to achieve satisfactory results gastric cancer. There need identify novel immunotherapy targets cancer.We analysed correlation between Treg cells CD8 + T samples. We studied relationship chemokines or compared...
11518 Background: NB003 is a potent and selective small-molecule tyrosine kinase inhibitor of KIT/PDGFRα. It was designed to inhibit broad spectrum primary acquired imatinib-resistant mutations in Methods: This first-in-human phase 1 study patients (pts) with advanced GIST who progressed on or intolerant imatinib other SoCs. Pts received oral twice daily (BID). An accelerated titration followed by Bayesian optimal interval (BOIN) design used. After the MTD MAD determined, putative RP2D(s)...
Background The use of lymph node (LN) tracers can help obtain a complete dissection the LNs and increase detection rate metastatic LNs. Carbon nanoparticle suspension injection (CNSI) has become increasingly used in radical gastrectomy procedures. This study is designed to evaluate quality LN gastric cancer patients with laparoscopic distal under guidance CNSI lymphography. Method was retrospective cohort including pathological biopsy diagnosis resectable who underwent gastrectomy. Data...
Abstract Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis induced and regulated after injury. Sonic hedgehog signaling participates in heart, liver, lung, kidney. Whether Shh modulates stroke underlying mechanisms are unclear. In this study, we found Hedgehog expression was upregulated patients with acute a middle artery occlusion/reperfusion rat model....
Acid-sensing ion channels (ASICs) are known to be primarily activated by extracellular protons. Recently, we characterized a novel nonproton ligand (2-guanidine-4-methylquinazoline, GMQ), which activates the ASIC3 channel subtype at neutral pH. Using an interactive computational-experimental approach, here extend our investigation delineate architecture of GMQ-sensing domain in channels. We first established GMQ binding mode and revealed that residues Glu-423, Glu-79, Leu-77, Arg-376,...
Abstract Gastrointestinal stromal tumor (GIST) is the most major mesenchymal neoplasm of digestive tract. Up to now, imatinib mesylate has been used as a standard first-line treatment for irresectable and metastasized GIST patients or adjuvant advanced who received surgical resection. However, secondary resistance usually happens, resulting in obstacle successful therapy. In this study, we first found that collagen calcium binding EGF domains 1 (CCBE1) expression gradually elevated along...
The mechanism underlying the pathogenesis of schizophrenia remains poorly understood. hyper-dopamine and hypo-NMDA receptor hypotheses have been most enduring ideas. Recently, emerging evidence implicates alterations major inhibitory system, GABAergic neurotransmission in schizophrenic patients. However, pathophysiological role system still dubious. In this study, we took advantage GABA transporter 1 (GAT1) knockout (KO) mouse, a unique animal model with elevated ambient GABA, to study...
Background Atherosclerosis has been recognized as a chronic inflammation initiated by dysfunction of endothelial cell that contributes to the increased morbidity and mortality severe cardiovascular events. The reported important role microRNA-98 (miR-98) in regulation behaviors prompt us hypothesize miR-98 could be involved process atherosclerosis.Methods Results current research showed expression was gradually down-regulated atherosclerotic mouse arteries isolated from ApoE ablation mice...