A5101475716- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Galectins and Cancer Biology
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Esophageal Cancer Research and Treatment
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Immune cells in cancer
- Synthesis of Organic Compounds
- Extracellular vesicles in disease
- Mechanisms of cancer metastasis
- FOXO transcription factor regulation
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
Shanghai Jiao Tong University
2016-2025
Guilin Medical University
2025
Renji Hospital
2012-2024
Beijing Great Wall Hospital
1995
Postoperative abdominal infectious complication (AIC) is associated with metastasis in locally advanced gastric cancer (GC) patients after radical gastrectomy. However, the underlying mechanism remains unclear. Herein, we report that neutrophil extracellular traps (NETs), DNA meshes released by neutrophils response to infection, could promote GC cells proliferation, invasion, migration and epithelial-mesenchymal transition dependent on TGF-β signaling. Then model nude mice cecal puncture...
Epidemiological studies have indicated an association between statin use and reduced incidence of colorectal cancer (CRC), work in preclinical models has demonstrated a potential chemopreventive effect. Statins are also associated with dysbiosis the gut microbiome, yet role microbiome protective effect statins CRC is unclear. Here we validated by retrospectively analysing cohort patients who underwent colonoscopies. This was confirmed patient cohorts, found that tumour burden partly due to...
Abstract The objective of this study was to evaluate the role HOTAIR long noncoding RNA in gastric cancer metastasis. We analyzed expression levels by real-time reverse transcription PCR and Northern blot analysis 100 tissues (50 50 adjacent normal mucosa), four cell lines. Transient RNAi-mediated knockdown pcDNA-mediated overexpression were performed. Stable shRNA-mediated lentiviral-mediated on vivo tumorigenicity metastatic burden context xenograft assays. Proteomic profiling performed...
Objective To develop a predictive model for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) through radiomics analysis, integrating data from both enhanced computed tomography (CT) and magnetic resonance imaging (MRI). Methods A retrospective analysis was conducted on 93 HCC patients who underwent partial hepatectomy. The gold standard MVI based the histopathological diagnosis of tissue. were randomly divided into training validation groups 7:3 ratio. patients, including CT...
Statins, commonly used to lower cholesterol, are associated with improved prognosis in colorectal cancer (CRC), though their effectiveness varies. This study investigates the anti-cancer effects of atorvastatin CRC using patient-derived organoids (PDOs) and PDO-derived xenograft (PDOX) models. Our findings reveal that induces mitochondrial dysfunction, leading apoptosis cells. In response, cells induce mitophagy clear damaged mitochondria, enhancing survival reducing statin efficacy....
MicroRNAs (miRNAs) are small non‑coding RNA molecules that regulate the expression of targeted genes in a post‑transcriptional manner. Increasing evidence indicates miRNAs play important roles cancer pathogenesis, including apoptosis, proliferation and differentiation, as oncogenes or tumor suppressors. Previously, miR‑375 was shown to be involved human gastric cancer, however, mechanism remains poorly understood. In present study, downregulated tissues, particularly epidermal growth factor...
Bile acid reflux and subsequent caudal-related homeobox 2 (CDX2) activation contribute to gastric intestinal metaplasia (IM), a precursor of cancer; however, the mechanism underlying this phenomenon is unclear. Here, we demonstrate that alkylation repair homolog protein 5 (ALKBH5), major RNA N6-adenosine demethylase, required for bile acid-induced IM. Mechanistically, revealed N6-methyladenosine (m6A) modification profile in IM first time identified ZNF333 as novel m6A target ALKBH5. ALKBH5...
Long non-coding RNAs (lncRNAs) act as tumor suppressors or oncogenes in development and progression. In this study, we explored the expression biological role of lncRNA NRON gastric cancer (GC). We observed that lncNRON was upregulated GC tissues cell lines, high associated with malignant features poor prognosis patients. LncNRON found to promote proliferation tumorigenicity cells. Mechanistically, exerted its oncogenic functions by binding N6-methyladenosine eraser ALKHB5 mediating Nanog...
Peritoneal metastasis is one of the common forms in gastric cancer (GC). In this study, we identified expression pattern LINC00589 GC patients and investigate biological function cells. RNA-pulldown assay was performed to explore underlying molecular mechanism. Further, utilize polyethyleneimine-modified mesoporous silica nanoparticles (PMSNs) as nanocarriers for delivery encoding plasmid tested its therapeutic potential with peritoneal dissemination. We revealed that downregulated tissues...
The dynein axonemal heavy chain (DNAH) family of genes encode the chain, which is involved in cell motility. Genomic variations DNAH members have been frequently reported diverse kinds malignant tumors. In this study, we analyzed genomic database to evaluate mutation status gastric adenocarcinoma and further identified significance mutant as effective molecular biomarkers for predicting chemotherapy response cancer patients. We clinical data patients published Cancer Genome Atlas (TCGA)...
FBXW7, a component of the Skp-Cullin1-F-box, mediates target protein recognition. It is tumor suppressor gene that plays role in regulation cell cycle exit and reentry via c-Myc, c-Jun Notch degradation. There are few studies, particularly involving large patient cohort, have evaluated FBXW7 during gastric cancer progression. Our study aimed to evaluate value as clinical marker adenocarcinoma (GC) patients including subset treated with postoperative chemotherapy. Quantitative reverse...
Background . In recent studies, aberrant expression of various microRNAs (miRNAs) is reported to be associated with gastric cancer metastasis. Method Overexpression construct and inhibitor hsa-miR-376c-3p were expressed in human adenocarcinoma cell line SGC-7901. The level tumor related genes was detected by qPCR, western blot, immunostaining. Cell apoptosis determined flow cytometry. Xenograft SGC-7901 cells used elucidate the function growth vivo Result Expression cells. Downregulation...
Background Gastric cancer occupies the fourth highest morbidity rate of cancers worldwide. A higher incidence gastric had been found in East Asia compared to other regions. Gastrectomy with radical lymph node dissection is cornerstone curative treatment for Stage III cancer, and postoperative systemic chemotherapy docetaxel, S-1 improved patients’ disease-free survival rates. However, advances immunotherapy bring innovations management patients cancer. The objective this study was explore...
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