A5100781745- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Metabolism, Diabetes, and Cancer
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Immune cells in cancer
- Advanced Breast Cancer Therapies
- Gut microbiota and health
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
Renji Hospital
2013-2025
Shanghai Jiao Tong University
2012-2025
Xian Yang Central Hospital
2025
State Grid Corporation of China (China)
2024
Shanghai Institute of Hematology
2015-2023
State Key Laboratory of Oncogene and Related Genes
2012-2023
Shanghai Cancer Institute
2014-2023
Tianjin University of Traditional Chinese Medicine
2022
Central People's Hospital of Zhanjiang
2019-2021
China National Rice Research Institute
2021
It is increasingly evident that long noncoding RNAs (lncRNA) have causative roles in carcinogenesis. In this study, we report findings implicating a novel lncRNA gastric cancer, termed GAPLINC (gastric adenocarcinoma predictive intergenic RNA), based on the use of global microarray and situ hybridization (ISH) analyses to identify aberrantly expressed human cancer specimens. 924-bp-long highly tissues. suppression with gene expression profiling cells revealed alterations cell migration...
Epidemiological studies have indicated an association between statin use and reduced incidence of colorectal cancer (CRC), work in preclinical models has demonstrated a potential chemopreventive effect. Statins are also associated with dysbiosis the gut microbiome, yet role microbiome protective effect statins CRC is unclear. Here we validated by retrospectively analysing cohort patients who underwent colonoscopies. This was confirmed patient cohorts, found that tumour burden partly due to...
Abstract Reversible post-translational modifications represent a mechanism to control tumor metabolism. Here we show that mitochondrial Sirtuin5 (SIRT5), which mediates lysine desuccinylation, deglutarylation, and demalonylation, plays role in colorectal cancer (CRC) glutamine metabolic rewiring. Metabolic profiling identifies deletion of SIRT5 causes marked decrease 13 C-glutamine incorporation into tricarboxylic-acid (TCA) cycle intermediates glutamine-derived non-essential amino acids....
Aims: To investigate the antitumor effects of probiotics Clostridium butyricum and Bacillus subtilis on colorectal cancer (CRC) progression. Materials & methods: The C. B. CRC cells were studied. Male C57BL/6 mice with 1,2-dimethylhydrazine dihydrochloride (DMH)-induced intervened by these two examined comparing tumor incidence detecting inflammatory immune-related markers. Results conclusions: inhibited proliferation cells, caused cell cycle arrest promoted apoptosis. In vivo, development...
Abstract Colorectal carcinogenesis coincides with immune cell dysfunction. Metformin has been reported to play a role in stimulating antitumor immunity, suggesting it could be used overcome immunosuppression colorectal cancer. Herein, using single-cell RNA sequencing (scRNA-seq), we showed that metformin remodels the landscape of In particular, treatment expanded proportion CD8+ T cells and potentiated their function. Analysis metabolic activities cancer tumor microenvironment (TME) at...
Here, we ascertained the clinical characteristics of Chinese patients with autoimmune gastritis (AIG) and determined correlation dietary lifestyle factors AIG occurrence development to establish a noninvasive predictive model for AIG. In this case-control study, enrolled 479 from seven independent centers nationwide in China; them, 279 had AIG, 112 chronic atrophic mostly antrum, 88 nonatrophic gastritis. Their data were systematically collected analyzed. Finally, multivariate logistic...
Aberrant methylation has been shown to trigger the inactivation of tumor suppressor genes during tumorigenesis. MicroRNAs (miRNAs) have found deregulated in human colorectal cancer (CRC), and some them may function as genes. Here, we investigated CpG island promoter hypermethylation a potential mechanism underlying miRNA disruption identifed methylation-sensitive miRNAs that might repress CRC development. We compared differential expression after 5-aza-2'-deoxycitidine (5-aza-dC) treatment...
Mutations of p53 cause not only loss wild-type function but also gain novel oncogenic functions (GOF). Accumulating evidence suggest that hotspot mutations may confer different types and magnitudes GOF. Here we add support to the heterogeneity mutant GOF by showing their unequal association with early tumor onset spectrum types. We stratified Li-Fraumeni syndrome (LFS) patients according carried using data from updated germline mutation database. When compared loss-of-function nonsense...
Many Rho GTPase activation proteins (RhoGAPs) are deleted or downregulated in cancers, but the functional consequences still unclear. Here, we show that RhoGAP ArhGAP11A induces cell-cycle arrest and apoptosis by binding to tumor suppressor p53. The domain of binds tetramerization p53, not its family members p63 p73. interaction stabilizes tetrameric conformation p53 enhances DNA-binding activity, thereby inducing apoptosis. Upon DNA damage stress, accumulates nucleus interacts with whereas...
Octamer transcription factor 1 (OCT1) was found to be expressed in intestinal metaplasia and gastric cancer (GC), but the exact roles of OCT1 GC remain unclear. The objective this study determine functional prognostic implications GC.Expression examined paired normal cancerous tissues significance analysed by univariate multivariate survival analyses. functions on synbindin expression extracellular signal-regulated kinase (ERK) phosphorylation were studied vitro xenograft mouse models.The...
In this study we investigated the biological role and mechanism of miR-198 in colorectal carcinoma (CRC). MiR-198 expression was shown to exhibit a strongly negative correlation with lymph node invasion, distant metastasis patient survival examinations cancer tissues paired normal mucosa tissues. fucosyl transferase 8 (FUT8) identified as potential target bioinformatics analysis luciferase reporter assays. Overexpression CRC cell lines decreased FUT8 levels by immunofluorescence inhibited...
The effect of metformin on gut microbiota has been reported, but whether can suppress colorectal cancer (CRC) by affecting composition and rescue F. nucleatum-induced tumourigenicity remains unclear.To identify associated with both CRC occurrence treatment, first, we reanalyzed the microbiome our previous data two human cohorts normal individuals. Subsequently, summarized altered from published literatures. Several taxa, including Fusobacterium, were treatment. We investigated APCMin/+ mice...
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor commonly inactivated in glioblastoma multiforme (GBM), but the prognostic significance of PTEN remains controversial. Here, we demon- strate significant value combined mutation expression for survival patients with GBM basis analysis large-scale cancer genomic data. nonsense mutations associated sig- nificantly shorter disease-free overexpression protein linked to overall GBM. correlated decreased p53 Gata3...
Antiangiogenesis therapy has shed new light on cancer treatment, but its effectiveness, especially for overall patient survival, is still controversial. Here, we show that antiangiogenesis treatment causes a persistent suppression of mitochondria biogenesis in colorectal cells, which renders them more sensitive to glycolytic blockade therapy. We first analyzed bevacizumab-resistant colon xenografts by two-dimensional Blue Native/SDS-PAGE and found serious loss mitochondrial protein complex...
The polycomb group protein enhancer of zeste homologue 2 (EZH2), which has histone methyltransferase (HMT) activity, is overexpressed in malignant tumours. However, the role EZH2 colorectal cancer (CRC) invasion little known. Here we investigated clinical significance, biological effects, and mechanisms signalling. Knockdown significantly reduced cell secretion matrix metalloproteinases 2/9 (MMP2/9) vitro studies. dramatically increased overall survival decreased metastasis lung vivo...
Persistent infection with Helicobacter pylori (H. pylori) contributes to gastric diseases including chronic gastritis and cancer. However, the pathogenesis of this carcinogenic bacterium has not been completely elucidated. Here, we report that H. rapidly triggers STAT3 signaling induces STAT3-dependent COX-2 expression both in vitro vivo. upregulates by binding increasing activity promoter. turn regulates IL-6/STAT3 under basal conditions during infection. These findings suggest a positive...