A5101703400- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Protein Kinase Regulation and GTPase Signaling
- Genomics and Chromatin Dynamics
- Hippo pathway signaling and YAP/TAZ
- Cellular transport and secretion
- Nerve injury and regeneration
- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
- Microtubule and mitosis dynamics
- Bone Tumor Diagnosis and Treatments
- Wnt/β-catenin signaling in development and cancer
- Sarcoma Diagnosis and Treatment
- Cellular Mechanics and Interactions
- Lung Cancer Treatments and Mutations
Renji Hospital
2008-2022
Shanghai Jiao Tong University
2008-2022
Yantaishan Hospital
2019-2021
Shandong University
2019
State Key Laboratory of Oncogene and Related Genes
2013-2018
Case Western Reserve University
2013-2017
Shanghai Institute of Hematology
2013-2017
XinHua Hospital
2017
First Affiliated Hospital of Zhengzhou University
2015
Aberrant methylation has been shown to trigger the inactivation of tumor suppressor genes during tumorigenesis. MicroRNAs (miRNAs) have found deregulated in human colorectal cancer (CRC), and some them may function as genes. Here, we investigated CpG island promoter hypermethylation a potential mechanism underlying miRNA disruption identifed methylation-sensitive miRNAs that might repress CRC development. We compared differential expression after 5-aza-2'-deoxycitidine (5-aza-dC) treatment...
Objective: Colorectal cancer (CRC) is one of the common malignant tumors worldwide. Chromobox (CBX) family proteins are important components epigenetic regulation complexes and implicated in development multiple cancers by blocking differentiation promoting proliferation. However, little known about function distinct CBX colorectal cancer. Methods: Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier plotter, cBioPortal, GeneMANIA, TIMER were utilized to analyze...
Osteosarcoma often requires multidisciplinary treatment including surgery, chemotherapy and radiotherapy. However, tumor behavior can vary widely among patients selection of appropriate therapies in any individual patient remains a critical challenge. Radiomics seeks to quantify complex aspects images under the assumption that this information is related biology. This study tested hypothesis radiomic signature extracted from Diffusion-weighted magnetic resonance (DWI-MRI) improve prediction...
The role of the mTOR signal pathway in colorectal cancer (CRC) pathogenesis remains unclear, and combination effect PD98059 (an inhibitor for MEK) rapamycin mTOR) on CRC is still unknown. Here, we found that treatment with suppressed proliferation cells, induced apoptosis, arrested cell cycle, reduced incidence volume mice, as well inhibited phosphorylation MEK components, which effects were more significant than single-drug treatments. These findings indicate combined appears to be a...
Krabbe disease ( KD ) is a rare caused by the deficiency of β‐galactocerebrosidase. This study investigated 22 unrelated Chinese patients, including their clinical presentations, plasma psychosine levels and β‐galactocerebrosidase gene mutations. We found late‐onset form present in 82% patients our study, which was more prevalent than from other populations. Plasma were elevated , correlated with severity presentations. Sanger sequencing identified 8 novel mutations, 7 missense p. H253Y...
Zinc finger protein 278 (ZNF278) is a novel Krueppel Cys2-His2-type zinc that ubiquitously distributed in human tissues. Whether ZNF278 related to the development of colorectal cancer still unclear. The transcriptional level was studied by real-time polymerase chain reaction. results showed expression increased 53% tissues compared corresponding non-cancerous down-regulation detected only three (6%) non-cancer No significant difference 19 (41%) pairs samples. However, we failed find...
Accumulating evidence has shown that microRNAs (miRNAs) are aberrantly expressed in human esophageal cancer and crucial to tumorigenesis.Herein, we identified the role of miR-29b squamous cell carcinoma (ESCC) development vitro vivo.MiR-29b expression was investigated thirty cases ESCC samples as well four lines by real-time PCR.Transwell assays were conducted explore effects on invasion lines.The impact overexpression putative target MMP-2 subsequently confirmed via Western blot.Our results...
Abstract The extracellular signal‐regulated kinase (ERK), mitogen‐activated protein (MAPK) pathway is an important cell proliferation pathway. We previously reported that the transport particle complex 4 (TRAPPC4), ERK2 interaction may activate ERK1/2, modulate pERK2 nuclear localization and regulate apoptosis in colorectal cancer (CRC) cells. present study further investigated function of TRAPPC4–ERK2 CRC vitro vivo. Silencing TRAPPC4 induced G0/G1 phase cycle arrest, upregulated p21...
Objective. Tumor suppressor gene silencing via promoter hypermethylation is an important event in the pathogenesis of colorectal cancer (CRC). Some aberrant DNA has high tumor specificity, so it may contribute to early diagnosis CRC. The objective this study was establish novel therapeutic and diagnostic strategies against CRC by identifying methylation-related genes. Material andmethods. Two microarray-based approaches were used identify genes We identified methylation-sensitive colon cell...
Gastric cancer (GC) is one of the most common malignancies, with an ever-increasing incidence and high mortality rate. Chromobox4 (CBX4), also named hPC2, a small ubiquitin-related modifier (SUMO) E3 ligase. Previous studies have found that CBX4 expression associated tumor size, pathologic differentiation decreased patient survival in hepatocellular carcinoma (HCC). However, prognostic value GC not been clarified. In our study, ONCOMINE, UALCAN, Kaplan-Meier Plotter, cBioPortal, DAVID 6.8...
The molecular mechanisms that control the development of colorectal cancer (CRC) remain poorly defined. Here we show Synbindin promoted CRC oncogenesis by activating Wnt signaling and altering gut microbiome. upregulation in human CRCs was associated with poor patient prognosis. Intestine‐specific disruption balanced disturbed microbiota protected mice against tumor formation colitis‐associated (CAC) model. protective role compromised after depletion. In host, increased goblet cells mucin2...
Purpose: Cervical cancer (CC) is the fourth most common with high death rate in females. The study aims to detect mechanism of long non-coding RNA (LncRNA) PCAT1 on radiosensitivity CC. Methods: expression PCAT1, miR-128 and GOLM1 CC tissues cells was measured by qRT-PCR. Different doses X-ray were used for radiation treatment 6 Gy chosen perform following experiments. proliferation, migration invasion MTT assay, wound healing assay transwell respectively. target relationships among...
Abstract Protein tyrosine nitration occurs under both physiological and pathological conditions 1 . However, enzymes that remove this protein modification have not yet been identified. Here we report the pseudo-phosphatase domain of receptor T (PTPRT) is a denitrase removes nitro-groups from residues in paxillin. PTPRT normally functions as tumor suppressor frequently mutated variety human cancers including colorectal cancer 2,3 We demonstrate some tumor-derived mutations located...
e21045 Background: It is unclear which one of signatures ΔCT or RQ values from gene expression respond better in chemotherapy evaluation. Improved understanding required for the comparison analysis FFPE and blood samples. Methods: 370 solid tumor consecutive samples were tested by quantitative PCR. Among all samples, 251 cases (108 lung cancer, 72 colon 44 gastric 27 breast cancer) with self-blood control enrolled thresholds set at 15-35 cycles, involved predictive biomarkers ERCC1, BRCA1,...