A5070927641- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Pancreatitis Pathology and Treatment
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Liver physiology and pathology
- Nanoplatforms for cancer theranostics
- Bone Tissue Engineering Materials
- Trace Elements in Health
- Cytokine Signaling Pathways and Interactions
- Natural product bioactivities and synthesis
- Cancer Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Peptidase Inhibition and Analysis
Affiliated Hospital of North Sichuan Medical College
2020-2025
Qilu Hospital of Shandong University
2020-2025
Lanzhou University
2021-2024
First Hospital of Lanzhou University
2022-2024
Chongqing University of Arts and Sciences
2024
Chongqing Academy of Chinese Materia Medica
2024
Chongqing University
2024
Xiaomi (China)
2024
Shanghai Eighth People Hospital
2024
Sichuan University
2023
Cholestatic liver diseases are characterized by excessive bile acid accumulation in the liver. Endothelial cells (ECs) shape local microenvironment both normal conditions and injury, yet their role cholestasis is unclear. Through a comparative analysis of single-cell RNA sequencing data from various murine models we identify distinctive Myc activation within ECs during obstructive resulting duct ligation (BDL). overexpression significantly upregulates P-selectin, increasing neutrophil...
Background. Hepatocellular carcinoma (HCC) remains a challenging medical problem. Cuproptosis is novel form of cell death that plays crucial role in tumorigenesis, angiogenesis, and metastasis. However, it unclear whether cuproptosis-related genes (CRGs) influence the outcomes immune microenvironment HCC patients. Method. From The Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases, we obtained mRNA expression file related clinical information We selected 19 CRGs as...
Pancreatic hamartoma is an extremely rare, non-neoplastic, mass-forming lesion that may be mistaken for malignancy, and the pre-operative diagnosis particularly challenging. The published literature contains only 23 cases of pancreatic hamartoma. majority reported patients with a single benign tumor‑like disease received pancreatectomy. Immunohistochemical findings confirmed following surgery. current study reports case 53-year-old female who presented to Department Abdominal Surgery,...
Angelica polysaccharides (AP) have numerous benefits in relieving type 2 diabetes (T2D). However, the underlying mechanisms yet to be fully understood. Recent many reports suggested that altering gut microbiota can adverse effects on host metabolism and contribute development of T2D. Here, we successfully established T2D model using male KKAy mice with high-fat high-sugar feed. Meanwhile, C57BL/6 were fed a normal either or without AP supplementation. In each group, measured mice's fasting...
To assess prognostic benefits of intraoperative electron beam radiation therapy (IOERT) in patients with nonmetastatic locally advanced pancreatic cancer (LAPC) and evaluate optimal adjuvant treatment after IOERT. A retrospective cohort study using prospectively collected data was conducted at the Cancer Hospital Chinese Academy Medical Sciences, China National Center. Two hundred forty-seven consecutive LAPC who underwent IOERT between January 2008 May 2015 were identified included study....
Gastric cancer (GC) is one of the most common malignant tumors in digestive system with high mortality globally. However, biomarkers that accurately predict prognosis are still lacking. Therefore, it important to screen for novel prognostic markers and therapeutic targets. We conducted differential expression analysis survival out genes. A stepwise method was employed select a subset genes multivariable Cox model. Overrepresentation enrichment (ORA) used search pathways associated poor...
The advanced gastric adenocarcinoma (GAC) patients (stage III/IV) with surgery may have inconsistent prognoses due to different demographic and clinicopathological factors. In this retrospective study, we developed clinical prediction models for estimating the overall survival (OS) cancer-specific (CSS) in GAC surgery.A analysis was conducted using Surveillance, Epidemiology, End Results (SEER) database. total population from 2004 2015 divided into four levels according age, of which 179...
Abstract Liver metastasis stands as the primary contributor to mortality among patients diagnosed with colorectal cancer (CRC). Neutrophil extracellular traps (NETs) emerge pivotal players in progression and of cancer, showcasing promise prognostic biomarkers. Our objective is formulate a predictive model grounded genes associated neutrophil identify novel therapeutic targets for combating CRLM. We sourced gene expression profiles from Gene Expression Omnibus (GEO) database. trap-related set...
Surface treatment is known as a very efficient measure by which to modulate the surface properties of biomaterials in terms grain structure, topography, roughness and chemistry determine osseointegration implants. In this work, two-step method modification was employed impart high osteogenic activity biomineralization capacity on Ti-25Nb-3Mo-2Sn-3Zr alloy (a type β-titanium named TLM). The preliminary mechanical attrition (SMAT) refined average size from 170 ± 19 μm 74 8 nm TLM layer...
Recent study in rabbits demonstrated that vasectomy via the inguinal canal did not result any spermatogenic damage 3 months postoperation; this aimed to determine whether would occur a longer term. The left or right vas deferens was ligated near epididymal head (unilateral proximal vasectomy, 12 animals) distal 11 adult male rabbits, with sham operation being performed on contralateral side. Six postoperation, testes, epididymides and vasa deferentia were removed methacrylate resin-embedded...
JinGuanLan (JGL) formula is a traditional Chinese medicine (TCM) developed by the Department of Pharmacology at First Hospital Lanzhou University. The network pharmacology approach was applied to determine potential active compounds, therapeutic targets, and main pathways JGL evaluate its application value in acne vulgaris.Data on compounds their related targets were obtained from Traditional Medicine Systems Database Analysis Platform (TCMSP). Acne vulgaris-related searched Online Mendelian...
The expression of angiopoietin (ANGPT) 1, ANGPT2, vascular endothelial growth factor (VEGF) A, VEGFB, VEGFC, VEGFD, and placental (PGF) is significantly higher in tumor tissues than normal both unpaired paired hepatocellular carcinoma (HCC) samples. PGF are primarily involved regulating the activation epithelial-mesenchymal transition pathway; ANGPT1 RAS/mitogen-activated protein kinase receptor tyrosine (RTK) pathways; VEGFA engaged RTK VEGFD mainly tuberous sclerosis protein/mammalian...
Abstract Hepatocellular carcinoma (HCC) remains a worldwide health problem. Mounting evidence indicates that exhausted T cells play critical role in the progress and treatment of HCC. Therefore, detailed characterisation their clinical significance warrants further investigation Based on GSE146115, we presented comprehensive single‐cell Atlas Pseudo‐time analysis revealed tumour heterogeneity progressively increased, gradually appeared during progression. Functional enrichment evolutionary...