A5015998327- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Thermochemical Biomass Conversion Processes
- Food Allergy and Anaphylaxis Research
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Coal and Its By-products
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Iron and Steelmaking Processes
- Crystallization and Solubility Studies
- Allergic Rhinitis and Sensitization
- Respiratory viral infections research
- Natural product bioactivities and synthesis
- Advanced biosensing and bioanalysis techniques
- X-ray Diffraction in Crystallography
- Pediatric health and respiratory diseases
- Thin-Film Transistor Technologies
- Metal Extraction and Bioleaching
- CAR-T cell therapy research
- Catalytic Processes in Materials Science
- Pharmacological Effects of Natural Compounds
University of Chicago
2019-2024
University of Washington
2014-2024
Seattle University
2018-2024
Tianjin University of Traditional Chinese Medicine
2022-2024
Community Health Center
2024
Cleveland Clinic Lerner College of Medicine
2023
Shenzhen Institutes of Advanced Technology
2022-2023
Guangxi University of Chinese Medicine
2023
Cleveland Clinic
2023
Shanghai University
2020-2022
The microbiome modulates host immunity and aids the maintenance of tolerance in gut, where microbial food-derived antigens are abundant. Yet modern dietary factors excessive use antibiotics have contributed to rising incidence food allergies, inflammatory bowel disease other non-communicable chronic diseases associated with depletion beneficial taxa, including butyrate-producing Clostridia. Here we show that intragastrically delivered neutral negatively charged polymeric micelles releasing...
Butyrate-a metabolite produced by commensal bacteria-has been extensively studied for its immunomodulatory effects on immune cells, including regulatory T macrophages and dendritic cells. However, the development of butyrate as a drug has hindered butyrate's poor oral bioavailability, owing to rapid metabolism in gut, low potency (hence, necessitating high dosing), foul smell taste. Here we report that bioavailability can be increased esterifying it serine, an amino acid transporter aids...
The COVID-19 pandemic underscores the need for rapid, safe, and effective vaccines. In contrast to some traditional vaccines, nanoparticle-based subunit vaccines are particularly efficient in trafficking antigens lymph nodes, where they induce potent immune cell activation. Here, we developed a strategy decorate surface of oxidation-sensitive polymersomes with multiple copies SARS-CoV-2 spike protein receptor-binding domain (RBD) mimic physical form virus particle. We evaluated vaccination...
Helicobacter pylori is a prevalent pathogen that colonizes the pylorus and contributes to pathogenesis of gastric cancer. The increasing antibiotic resistance in H. presents substantial challenge for effective eradication, making development more therapeutic strategies imperative. In this study, we screened 37 pure compounds (purity >95%), 3 ethanol extracts, 6 aqueous extracts from different medicinal herbs their potential inhibitory effects against vitro . Among tested compounds, 15...
A new family of fluorinated polyimides with four pendant trifluoromethylphenyl groups was prepared. The incorporation multi-bulky and large noncoplanar structures brought about great improvement for their properties.
Nanocarrier-based drug delivery systems are playing an emerging role in human immunodeficiency virus (HIV) chemoprophylaxis and treatment due to their ability alter the pharmacokinetics improve therapeutic index of various antiretroviral (ARV) compounds used alone combination. Although several nanocarriers have been described for combination ARV drugs, measurement drug-drug activities facilitated by use these nanotechnology platforms has not fully investigated topical prevention. Here, we...
The SARS-CoV-2 virus has caused an unprecedented global crisis, and curtailing its spread requires effective vaccine which elicits a diverse robust immune response. We have previously shown that vaccines made of polymeric glyco-adjuvant conjugated to antigen were in triggering such response other disease models hypothesized the technology could be adapted create against SARS-CoV-2. core platform is copolymer p(Man-TLR7), composed monomers with pendant mannose or toll-like receptor 7 (TLR7)...
Rabdosia rubescens, a commonly used traditional Chinese medicine, has increasingly gained attention for its use as an antitumor herb. Oridonin, bioactive diterpenoid isolated from been reported to induce apoptosis in human laryngeal cancer HEp-2 cells by our group. Here, we made unexpected observations that the caspase-9 inhibitor (C9i) enhanced response selected stimuli, and which were deficient using siRNA exhibited no resistance apoptotic signals actually demonstrated increased...
Targeted nanocarriers deliver HIV-1 latency-reversing agents to CD4 + T cells in the lymph nodes.
Synthesis of noble metal nanoparticles with controllable sizes and morphologies by environment-friendly methods is scientifically important technologically challenging. Here, we report fabrication monodispersed silver (AgNPs) in aqueous conditions dendronized chitosan oligosaccharides (CSOs) as templates. These CSOs carry three-folded dendritic oligoethylene glycol pendants, which integrate the features biocompatibility from oligosaccharides, well multi-valency crowding structure effects...
Epidermal growth factor receptor (EGFR), a transmembrane glycoprotein, is expressed at high levels in large proportion of laryngeal squamous cell carcinoma (LSCC). Cetuximab (Cet), an anti-EGFR monoclonal antibody, has limited clinical outcome for patients with head and neck carcinoma. Our previous studies showed that oridonin (ORI), natural safe kaurene diterpenoid isolated from Rabdosia rubescens, inhibited HEp-2 cells through inhibition EGFR phosphorylation. The aim the present study was...
The only FDA-approved oral immunotherapy for a food allergy provides protection against accidental exposure to peanuts. However, this therapy often causes discomfort or side effects and requires long-term commitment. Better preventive therapeutic solutions are urgently needed. We develop tolerance-inducing vaccine technology that utilizes glycosylation-modified antigens induce antigen-specific non-responsiveness. administered intravenously (i.v.) subcutaneously (s.c.) traffic the liver lymph...
: Pangdahai (matured, ripened, and dried seeds of Scaphium affine (Mast.) Pierre) is widely used in managing several diseases countries like China, Vietnam, Japan, India. This study evaluated the anti-inflammatory effects crude extracts (ethanol aqueous) isolated compounds Pangdahai. Xylene-induced ear edema mice, carrageenan-induced paw rats, nitric oxide (NO) assay were to evaluate screen from ethanolic TNF-α IL-1β levels tissues rat foot determined by ELISA. The cytotoxicity was also MTT...
Inverse vaccines that tolerogenically target antigens to antigen-presenting cells (APCs) offer promise in prevention of immunity allergens and protein drugs treatment autoimmunity. We have previously shown targeting hepatic APCs through intravenous injection synthetically glycosylated antigen leads effective induction antigen-specific immunological tolerance. Here, we demonstrate these glycoconjugates lymph node (LN) under homeostatic conditions local increased accumulation the LNs compared...
Regulation of protein activity is important in their applications for biomedicine and therapeutics. Here, an approach the regulation bioactivity through molecular confinement provided by oligoethylene glycol (OEG)-based dendronized chitosan (DCS) hydrogels reported. Structural effects on thermoresponsiveness are investigated. The highly transparent formed from thermoresponsive DCSs thermal dehydration exhibit intriguing reversible sol–gel transition property when triggered at physiological...