A5100624270- Advanced Optimization Algorithms Research
- Optimization and Variational Analysis
- Iterative Methods for Nonlinear Equations
- Sparse and Compressive Sensing Techniques
- Matrix Theory and Algorithms
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Diet and metabolism studies
- Nutritional Studies and Diet
- Inflammasome and immune disorders
- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Advanced Glycation End Products research
- Immune Response and Inflammation
- CAR-T cell therapy research
- Ginseng Biological Effects and Applications
- Immune Cell Function and Interaction
- Chemical synthesis and alkaloids
- Agriculture Sustainability and Environmental Impact
- Solar-Powered Water Purification Methods
- Alkaloids: synthesis and pharmacology
- Autophagy in Disease and Therapy
- Additive Manufacturing and 3D Printing Technologies
- Phagocytosis and Immune Regulation
- Psychedelics and Drug Studies
Northwest University
2019-2024
Rongcheng City People's Hospital
2024
Jiangsu University
2024
North China University of Technology
2024
Ministry of Education of the People's Republic of China
2021-2023
Northeastern University
2022
Tongji Hospital
2015
Huazhong University of Science and Technology
2015
Qufu Normal University
1998-2013
Kao Yuan University
2003
Importance Tongxinluo, a traditional Chinese medicine compound, has shown promise in vitro, animal, and small human studies for myocardial infarction, but not been rigorously evaluated large randomized clinical trials. Objective To investigate whether Tongxinluo could improve outcomes patients with ST-segment elevation infarction (STEMI). Design, Setting, Participants Randomized, double-blind, placebo-controlled trial was conducted among STEMI within 24 hours of symptom onset from 124...
G protein-coupled receptors (GPCRs) are currently the most widely focused drug targets in clinic, exerting their biological functions by binding to chemicals and activating a series of intracellular signaling pathways. Formyl-peptide receptor 1 (FPR1) has typical seven-transmembrane structure GPCRs can be stimulated large number endogenous or exogenous ligands with different chemical properties, first which was identified as formyl-methionine-leucyl-phenylalanine (fMLF). Through...
Ischemic stroke is characterized by insufficient blood supply to brain tissue and associated with increased morbidity mortality in adults worldwide. Growth arrest-specific protein 6 (GAS6) a vitamin K-dependent widely expressed the central nervous system. The biological functions of GAS6 are mediated interaction TAM (Tyro3, Axl Mertk) receptors, including cell survival proliferation, immune regulation apoptosis. Omentin-1, also known as intelectin-1 (ITLN-1), novel adipocytokine that...
Helicobacter pylori is a prevalent pathogen that colonizes the pylorus and contributes to pathogenesis of gastric cancer. The increasing antibiotic resistance in H. presents substantial challenge for effective eradication, making development more therapeutic strategies imperative. In this study, we screened 37 pure compounds (purity >95%), 3 ethanol extracts, 6 aqueous extracts from different medicinal herbs their potential inhibitory effects against vitro . Among tested compounds, 15...
Abstract Most sepsis deaths are due to the development of multiple organ failure, in which heart failure is a recognized manifestation sepsis. To date, role liver X receptors α (NR1H3) still uncertain. Here, we hypothesized that NR1H3 mediates essential sepsis‐related signalings attenuate septic failure. Adult male C57BL/6 or Balbc mice and HL‐1 myocardial cell line were performed for vivo vitro experiments, respectively. knockout agonist T0901317 was applied evaluate impact on We found...
Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechanisms of nanoFe septic cardiomyopathy remain unknown.NanoFe was prepared via liquid-phase reduction method functionalized with biocompatible polymer sodium carboxymethylcellulose (CMC). We then successfully constructed mouse model myocardial injury by challenging cecal ligation puncture...
In this paper, based on a new class of asymptotic l 1 exact penalty functions, we propose smooth function for solving nonlinear programming problems. One the main features our algorithm is that at each iteration, do not need to solve global minimum functions. Furthermore, convergence property established without requiring any constraint qualifications. By addressing perturbation obtain lower semi-continuity zero necessary and sufficient condition ensure objective values generated by optimal...