A5029283228- MicroRNA in disease regulation
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Protease and Inhibitor Mechanisms
- Cancer-related molecular mechanisms research
- Ion Transport and Channel Regulation
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Nitric Oxide and Endothelin Effects
- Nuclear Receptors and Signaling
- Chemical Synthesis and Analysis
- Calpain Protease Function and Regulation
- Cerebral Palsy and Movement Disorders
- Prostate Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Balance, Gait, and Falls Prevention
- Natural product bioactivities and synthesis
- Sirtuins and Resveratrol in Medicine
- Medicinal Plant Pharmacodynamics Research
- Endoplasmic Reticulum Stress and Disease
- Venous Thromboembolism Diagnosis and Management
Northwest University
2020-2024
Huawei Technologies (China)
2024
Fujian Medical University
2010-2024
Union Hospital
2019-2024
Xi'an Medical University
2023
Ministry of Education of the People's Republic of China
2022-2023
Xian Central Hospital
2017-2021
Xi'an Jiaotong University
1994-2021
First Hospital of Xi'an
2021
Wuhan No.1 Hospital
2019
Background: Breast cancer is a common worldwide. Triple-negative breast (TNBC) an aggressive form of characterized by poor prognosis. Icariin (ICA) flavonoid glycoside purified from the natural product Epimedium, which reported to exert inhibitory effect on variety cancers. However, molecular mechanisms behind ICA suppressed TNBC remain elusive. Methods: The curative effects cells and potential targets were predicted network pharmacology biology methods screening, mechanism inhibition was...
Abstract We recently found that 5‐lipoxygenase (5‐LOX) is activated to produce cysteinyl leukotrienes (CysLTs), and CysLTs may cause neuronal injury astrocytosis through activation of CysLT 1 2 receptors in the brain after focal cerebral ischemia. However, property astrocyte responses vitro ischemic not clear; whether 5‐LOX, CysLTs, their are also involved astrocytes remains unknown. In present study, we performed oxygen‐glucose deprivation (OGD) followed by recovery induce ischemic‐like...
Abstract Objectives Previously we demonstrated the neuroprotective effect of montelukast, a cysteinyl leukotriene receptor-1 (CysLT1) antagonist, on acute brain injury after focal cerebral ischaemia in mice. In this study, have determined its chronic mice and rats. Methods After transient was induced by middle artery occlusion, montelukast intraperitoneally injected or orally administered to rats for five days. Behavioural dysfunction, infarct volume, atrophy neuron loss were evaluate...
Ischemic stroke is characterized by insufficient blood supply to brain tissue and associated with increased morbidity mortality in adults worldwide. Growth arrest-specific protein 6 (GAS6) a vitamin K-dependent widely expressed the central nervous system. The biological functions of GAS6 are mediated interaction TAM (Tyro3, Axl Mertk) receptors, including cell survival proliferation, immune regulation apoptosis. Omentin-1, also known as intelectin-1 (ITLN-1), novel adipocytokine that...
Abstract Objective The prognosis for patients presenting with a large ischemic core (LIC) following endovascular thrombectomy is relatively poor. This study aimed to construct and validate nomogram predicting 3‐month unfavorable outcome in anterior circulation occlusion‐related LIC who underwent thrombectomy. Methods A retrospective training cohort prospective validation of were studied. diffusion weighted imaging related radiomic features pre‐thrombectomy clinical collected. After the...
Vascular endothelial cells (ECs) senescence plays a crucial role in vascular aging that promotes the initiation and progression of cardiovascular disease. The mutation Grb10-interacting GYF protein 2 (GIGYF2) is strongly associated with pathogenesis aging-related diseases, whereas its regulating ECs dysfunction still remains elusive. In this study, we found aberrant hyperexpression GIGYF2 senescent human aortas old mice. Silencing suppressed eNOS-uncoupling, senescence, dysfunction....
Objectives Olfactory disorder is one of the sensory features that reflects a decline in cognitive function. However, olfactory changes and discernibility smell testing aging population have yet to be fully elucidated. Therefore, this study aimed examine effectiveness Chinese Smell Identification Test (CSIT) distinguishing individuals with from those normal determine whether patients MCI AD show their identification abilities. Methods This cross-sectional included eligible participants aged...
Prostate biopsies are frequently performed to screen for prostate cancer (PCa) with complications such as infections and bleeding. To reduce unnecessary biopsies, here we designed an improved predictive model of MRI-based volume associated zone-adjusted prostate-specific antigen (PSA) concentrations diagnosing PCa risk stratification. Multiparametric MRI administered 422 consecutive patients before initial transrectal ultrasonography-guided 13-core from January 2012 March 2018 at Fujian...
Gait disorder is associated with cognitive functional impairment, and this disturbance more pronouncedly when performing additional tasks. Our study aimed to characterize gait disorders in mild impairment (MCI) under three dual tasks determine the association between performance function.A total of 260 participants were enrolled cross-sectional divided into MCI cognitively normal control. Spatiotemporal kinematic parameters (31 items) single task (serial 100-7, naming animals words recall)...
Intracellular calcium homeostasis disorder and mitochondrial dysfunction are involved in many acute chronic brain diseases, including ischemic injury. An imbalance fission fusion is one of the most important structural abnormalities found a large number related diseases. Here, we investigated effects division inhibitor A (mdivi A) mdivi B, two small molecule inhibitors protein dunamin-related 1 (Drp-1), neuronal injury induced by oxygen-glucose deprivation (OGD) PC12 cells. We that B...
With an enormous amount of research concerning kidney cancer being conducted, various treatments have been applied to its cure. However, high recurrence and metastasis rates continue pose a threat the survival patients with renal clear cell carcinoma (KIRC). Data from The Cancer Genome Atlas were downloaded, series analyses performed, including differential analysis, Cox weighted gene coexpression network least absolute shrinkage selection operator multivariate receiver operating...
Abstract Cerebral injury is closely associated with enhanced oxidative stress. A newly discovered secretory adipocytokine, intelectin‐1 (ITLN‐1), has been shown to have beneficial effects in neuroprotection epidemiological studies. However, the specific molecular mechanism of ITLN‐1 protecting against cerebral stress needs further investigation. In this study, we hypothesize that plays a protective role through SIRT1/PGC1‐α signaling pathway neuromatocytes. We used hydrogen peroxide (H 2 O )...
Gastric cancer (GC) is one of the most prevalent cancers worldwide. Ferroptosis and immune status tumor tissue play vital roles in initiation progression GC. However, role functional mechanisms ferroptosis- immunity-related genes (FIRGs) GC pathogenesis their correlations with prognosis have not been elucidated. We aim to establish a prognostic prediction model based on FIRGs signature for patients. Differentially expressed were screened from Cancer Genome Atlas (TCGA) cohorts. The least...
Macrophages, as essential components of the tumor immune microenvironment (TIME), could promote growth and invasion in many cancers. However, role macrophages (TME) immunotherapy PCa is largely unexplored at present. Here, we investigated roles macrophage-related genes molecular stratification, prognosis, TME, immunotherapeutic response PCa. Public databases provided single-cell RNA sequencing (scRNA-seq) bulk RNAseq data. Using Seurat R package, scRNA-seq data was processed macrophage...