A5060964641- Cancer, Hypoxia, and Metabolism
- Medicinal Plant Pharmacodynamics Research
- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Natural product bioactivities and synthesis
- Thyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
Northwest University
2022-2023
Background: Breast cancer is a common worldwide. Triple-negative breast (TNBC) an aggressive form of characterized by poor prognosis. Icariin (ICA) flavonoid glycoside purified from the natural product Epimedium, which reported to exert inhibitory effect on variety cancers. However, molecular mechanisms behind ICA suppressed TNBC remain elusive. Methods: The curative effects cells and potential targets were predicted network pharmacology biology methods screening, mechanism inhibition was...
Lactate, an intermediate product of glycolysis, has become essential regulator tumor maintenance, development, and metastasis. Lactate can drive tumors by changing the microenvironment cells. Because lactate's important role in cancer, we aim to find a novel prognostic signature based on lactate metabolism-related genes (LMRGs) breast cancer (BC).
Several observational studies have confirmed the relationship between thyroid hormones and coronavirus disease 2019 (COVID-19), but this correlation remains controversial. We performed a two-sample Mendelian randomization (MR) analysis based on largest publicly available summary datasets. Summary statistics with 49 269 individuals for free thyroxine (FT4) 54 288 stimulating hormone (TSH) were used as exposure instruments. Genome-wide association of susceptibility (cases = 38 984; controls 1...