A5080422097- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Renal cell carcinoma treatment
- Computational Drug Discovery Methods
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
Jianghan University
2023
Northwest University
2021
Gastric cancer (GC) is one of the leading causes cancer-related death worldwide. MicroRNAs (miRNAs) are known to be important regulators GC. This study aims investigate role miRNA (miR)-497 in We demonstrated that expression miR-497 was downregulated human GC tissues. After N-methyl-N-nitrosourea treatment, incidence knockout mice significantly higher than wild-type mice. overexpression suppressed cell proliferation, cell-cycle progression, colony formation, anti-apoptosis ability, and...
With an enormous amount of research concerning kidney cancer being conducted, various treatments have been applied to its cure. However, high recurrence and metastasis rates continue pose a threat the survival patients with renal clear cell carcinoma (KIRC). Data from The Cancer Genome Atlas were downloaded, series analyses performed, including differential analysis, Cox weighted gene coexpression network least absolute shrinkage selection operator multivariate receiver operating...
Abstract Alzheimer’s disease (AD) is a severe neurodegenerative for which there currently no effective treatment. Mild cognitive impairment (MCI) an early that may progress to AD. The diagnosis of AD and MCI in the stage has important clinical significance. Methods To this end, paper proposed hypergraph-based netNMF (HG-netNMF) algorithm integrating structural magnetic resonance imaging (sMRI) with corresponding gene expression profiles. Results Hypergraph regularization assumes regions...