Abstract Background Tumor angiogenesis, an essential process for cancer proliferation and metastasis, has a critical role in prognostic of kidney renal clear cell carcinoma (KIRC), as well target guiding treatment with antiangiogenic agents. However, tumor angiogenesis subtypes potential epigenetic regulation mechanisms KIRC patient remains poorly characterized. System evaluation might help to reveal the develop more treatments patients. Method Ten independent signatures were obtained from...

In the quest for efficient tumor diagnosis via liquid biopsy, extracellular vesicles (EVs) have shown promise as a source of potential biomarkers. This study addresses gap in biomarker efficacy predicting clinically significant prostate cancer (csPCa) between Western and Chinese populations. We developed urinary vesicles-based score (EPS) model, utilizing EXODUS technique EV isolation from 598 patients incorporating gene expressions FOXA1, PCA3, KLK3. Our findings reveal that EPS model...

Prostate cancer (PCa) is definitively diagnosed by systematic prostate biopsy (SBx) with 13 cores. This method, however, can increase the risk of urinary retention, infection and bleeding due to excessive number We retrospectively analyzed 622 patients who underwent SBx multiparametric MRI (mpMRI) from two centers between January 2014 June 2022. The data were collected manually segment Regions Interest (ROI) tumor layer layer. ROI reconstructions fused form outline volume interest (VOI),...

Abstract Objective Immune cells residing in the testicular interstitial space form immunological microenvironment of testis. They are assumed to play a role maintaining homeostasis and immune privilege. However, status related cell polarization patients with nonobstructive azoospermia (NOA) remains poorly characterized. System evaluation testis NOA may help reveal mechanisms idiopathic azoospermia. Study design The gene expression patterns normal human testes were systematically analyzed by...

Prostate biopsies are frequently performed to screen for prostate cancer (PCa) with complications such as infections and bleeding. To reduce unnecessary biopsies, here we designed an improved predictive model of MRI-based volume associated zone-adjusted prostate-specific antigen (PSA) concentrations diagnosing PCa risk stratification. Multiparametric MRI administered 422 consecutive patients before initial transrectal ultrasonography-guided 13-core from January 2012 March 2018 at Fujian...

Chronic inflammation of the male genital tract is thought to be a primary etiological factor infertility. The abundance and activation macrophages dendritic cells in patients with chronic were closely associated oligozoospermia asthenospermia. epididymitis appears more important than seminal vesiculitis or prostatitis due direct interaction between spermatozoa epididymal inflammatory cells. In this study, we present case report 41-year-old oligoasthenospermia epididymitis. Hematoxylin-eosin...

Background: Prostate cancer (PCa) is one of the most common tumors urinary system. Cuproptosis a novel mode controlled cell death that related to development various tumor types. However, functions cuproptosis-related long noncoding RNAs (CRLs) in PCa have not yet been well studied. Methods: In this study, data patients were obtained from The Cancer Genome Atlas (TCGA) and Changhai Hospital. Univariate multivariate Cox regression analyses LASSO analysis conducted screen CRLs linked prognosis...

Abstract Background Radical prostatectomy remains the fundamental treatment for prostate cancer, and improving patients’ compliance with postoperative follow-ups is essential quality of life. This study investigates effect education levels on recovery follow-up after radical prostatectomy. Methods Data from 1,112 patients undergoing between 2011 2020 were collected using medical records, “pc-follow” systems used to collect baseline information, level, pathological number outpatient visits,...

Abstract Background Prostate cancer (PCa) is definitively diagnosed by systematic prostate biopsy (SBx) with 13 cores. This method, however, can increase the risk of urinary retention, infection and bleeding due to excessive number Methods We retrospectively analyzed 622 patients who underwent SBx multiparametric MRI (mpMRI) from two centers between January 2014 June 2022. The data were collected manually segment Regions Interest (ROI) tumor layer by-layer. ROI reconstructions fused form...

Macrophages, as essential components of the tumor immune microenvironment (TIME), could promote growth and invasion in many cancers. However, role macrophages (TME) immunotherapy PCa is largely unexplored at present. Here, we investigated roles macrophage-related genes molecular stratification, prognosis, TME, immunotherapeutic response PCa. Public databases provided single-cell RNA sequencing (scRNA-seq) bulk RNAseq data. Using Seurat R package, scRNA-seq data was processed macrophage...

Radiomics models have demonstrated good performance for the diagnosis and evaluation of prostate cancer (PCa). However, there are currently no validated imaging that can predict PCa or clinically significant (csPCa). Therefore, we aimed to identify best such prediction csPCa.

Background Prostate cancer (PCa) is the most common malignant tumor of male urinary system. Cuproptosis, as a novel regulated cell death, remains unclear in PCa. This study aimed to investigate role cuproptosis-related genes (CRGs) molecular stratification, prognostic prediction, and clinical decision-making Methods Cuproptosis-related subtypes were identified by consensus clustering analysis. A signature was constructed with LASSO cox regression analyses 10-fold cross-validation. It further...

PBRM1 is a tumor suppressor frequently mutated in clear cell renal carcinoma. However, no effective targeted therapies exist for ccRCC with loss. To identify novel therapeutic approaches to targeting PBRM1-deficient cancers, we employed synthetic lethality compound screening isogenic PBRM1+/+ and PBRM1-/- 786-O cells found that DNMT inhibitor 5-Fluoro-2’-deoxycytidine (Fdcyd) selectively inhibit growth. RCC lacking show enhanced DNA damage response, which leads sensitivity toxic drugs. Fdcyd...

To reduce unnecessary prostate biopsies, we designed a magnetic resonance imaging (MRI)-based nomogram prediction model of maximum sectional area (PA) and investigated its zone for diagnosing cancer (PCa).MRI was administered to 691 consecutive patients before biopsies from January 2012 2020. PA, central gland (CGA), peripheral (PZA) were measured on axial T2-weighted MRI. Multivariate logistic regression analysis under the receiver operating characteristic (ROC) curve performed evaluate...

Purpose To establish an individualized prostate biopsy model that reduces unnecessary cores based on multiparameter MRI (mpMRI). Materials and Methods This retrospective, non-inferiority dual-center study retrospectively included 609 patients from the Changhai Hospital June 2017 to November 2020 431 Fujian Union between 2014 2019. Clinical, radiological, pathological data were analyzed. Data used for modeling by calculating patients’ disease risk scores. external verification. Results Based...

Background: The adenylyl cyclase (ADCY) gene family encodes enzymes responsible for the synthesis of cyclic adenosine monophosphate (cAMP) from triphosphate (ATP), which comprises nine transmembrane isoforms (ADCYs 1–9). Although ADCYs correlate with intracellular signalling and tumorigenesis in different malignancies, their roles bladder cancer remain unclear. Methods: Utilizing urothelial carcinoma (BLCA) dataset Cancer Genome Atlas (TCGA), we employed R package 'limma' to identify...

Abstract Background The beta-1,4-N-acetyl-galactosaminyltransferase 4 (B4GALNT4) gene, encoding glycosyltransferase is involved in tumor-associated glycoprotein biosynthesis different cancer types, which influences cell proliferation, migration, invasion and metastasis. However, the correlation between expression of B4GALNT4 pan-cancers prognosis, immune infiltration, mutation tumor-related gene was under investigated. Methods analyzed using data from Cancer Genome Atlas (TCGA),...

Objective To identify the risk factors for prostate-sparing cystectomy by evaluating of prostatic invasion or incidental adenocarcinoma(PCa) in bladder cancer(BCa) patients undergoing radical cystectomy. Methods The from 2009 to 2014 Fujian Medical University Union Hospital were enrolled analyze tumor invasion. These included age, size, location, quantity, histologic grade and pathologic stage. Results In 123 male patients, mean age was 60 years( range, 31-78 years); 23(18.7%)...

Objective To explore risk factors of the progression to castration-resistant prostate cancer(CRPC)after hormone therapy (HT). Methods A total 178 patients with cancer from February 2009 2018 were enrolled analyze after androgen deprivation in Fujian Medical University Union Hospital. The mean age was 72 years ( range, 49-91 years); middle Gleason score 7 (range, 4-10); PSA at initiation HT 24.45 ng/ml 0.16-100.0 ng/ml); time nadir 9 months 0.5-69.0 months); 0.030 0.003-78.670...