A5065342624- Ovarian cancer diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Uterine Myomas and Treatments
- COVID-19 Clinical Research Studies
- Urinary and Genital Oncology Studies
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Colorectal and Anal Carcinomas
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Metabolomics and Mass Spectrometry Studies
- Adrenal and Paraganglionic Tumors
- Reproductive System and Pregnancy
- interferon and immune responses
- Angiogenesis and VEGF in Cancer
- Sirtuins and Resveratrol in Medicine
- Cancer Mechanisms and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- Cardiomyopathy and Myosin Studies
- COVID-19 diagnosis using AI
The First Affiliated Hospital, Sun Yat-sen University
2023-2025
Fudan University
2006-2025
Zhongshan Hospital of Xiamen University
2024-2025
Zhongshan Hospital
2023-2025
Sun Yat-sen University
2023-2025
Fujian Medical University
2022-2025
Union Hospital
2025
Obstetrics and Gynecology Hospital of Fudan University
2012-2024
Sichuan University
2011-2024
West China Second University Hospital of Sichuan University
2014-2024
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 infection, has been spreading globally. We aimed to develop a clinical model predict the outcome of patients with COVID-19 infection early.Demographic, and first laboratory findings after admission 183 (115 survivors 68 non-survivors from Sino-French New City Branch Tongji Hospital, Wuhan) were used predictive models. Machine learning approaches select features patients' outcomes. The area under...
Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been spreading globally. The number of deaths increased with the increase in infected patients. We aimed to develop a clinical model predict outcome COVID-19 patients early. Methods Epidemiological, clinical, and first laboratory findings after admission 183 (115 survivors 68 nonsurvivors) from Sino-French New City Branch Tongji Hospital were used...
Abstract Among the proinflammatory mediators, platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a major primary and secondary messenger involved in intracellular extracellular communication. Evidence suggests that PAF plays significant role oncogenic transformation, tumor growth, angiogenesis, metastasis. However, PAF, with its receptor (PAFR) their downstream signaling targets, has not been thoroughly studied cancer. Here, we characterized PAFR...
Abstract Ovarian steroid cell tumors, not otherwise specified (NOS) are rare sex cord-stromal tumors of the ovary with malignant potential. So far only a few cases were reported in English literature through Pubmed search. Here we report two such tumor, one was benign (first case underwent laparoscopic cystectomy) and other (died 10 months later after initial diagnosis), both presented amenorrhea clinical signs or symptoms virilization. In case, provided evidence (tumor embolus) addition to...
Gastrointestinal (GI) fistula is a well-recognized complication of acute pancreatitis (AP). However, it has been reported in limited literature. This study aimed to evaluate the incidence and outcome GI fistulas AP patients complicated with infected pancreatic or peripancreatic necrosis (IPN). Between 2010 2013 IPN who diagnosed our center were analyzed this retrospective study. And we also conducted comparison between without regarding baseline characteristics outcomes. Over 4 years, total...
This is the first and largest prospective, multicenter, active, population-based surveillance study of epidemiology Mycoplasma pneumoniae among outpatient children with mild respiratory tract infections (RTIs) during COVID-19 pandemic. Nationwide measures like strict face mask wearing restrictions on population movement implemented to prevent spread might also effectively M. .
Evaluate the clinical significance of esophagogastric junction (EGJ) morphology and contractile integral (EGJ-CI) in refractory gastroesophageal reflux disease (RGERD) patients. From June 2021 to 2023, 144 RGERD patients underwent comprehensive evaluation, recording symptom scores, demographic data. GERD classification (NERD or RE, A-D) was based on endoscopic findings. Reflux assessed through 24-hour pH-impedance monitoring, high-resolution esophageal manometry(HREM) measured parameters...
703 Background: For decades, intravesical Bacillus Calmette-Guérin (BCG) has been the standard treatment for high-risk non-muscle-invasive bladder cancer (HR NMIBC). However, its poor tolerability and limited availability underscore urgent need more effective therapies. Intravesical sequential gemcitabine docetaxel (GemDoce) demonstrated efficacy in HR NMIBC, immune checkpoint inhibitors (ICIs) have shown effectiveness as second-line therapy patients with BCG-unresponsive NMIBC....
Objectives: The purpose of this study was to analyze the effect different movement strategies, embossment structures, and torque compensation aligner on tooth during arch expansion using clear aligners by finite element analysis. Methods: Models comprising maxilla, dentition, periodontal ligament, were created imported into a analysis software. tests performed following: three orders (including alternating with first premolar molar, whole second molar or premolars molar), four shapes...
Abstract The association of pseudo-Meigs' syndrome, elevation CA 125 to the struma ovarii is a rare condition. So far only nine cases have been reported in English literature through MEDLINE search. Here we report 46-year-old case ovarii, presented with ascites, hydrothorax, right ovarian mass and elevated serum level. These findings were misdiagnosed for an malignancy at first impression. Immediate resolution hydrothorax normalization level followed by removal. Struma could be cause 125....
The tumour microenvironment conferred by mesenchymal stem cells (MSCs) plays a key role in development and progression. We previously determined that platelet-activating factor receptor (PAFR) was overexpressed ovarian cancer (OCCs) PAF can promote progression via PAF/PAFR-mediated inflammatory signalling pathways. Evidence suggests MSCs secrete high concentrations of PAF. Here, we investigated the PAF/PAFR mediated OCCs its effect on progression.The culture media MSCs, co-cultured were...
Abstract Infants who are small for gestational age (SGA) at increased risk of neonatal and infant death, non-communicable diseases growth retardation. However, the epidemiological characteristics SGA remain unclear. We aim to explore prevalence examine its socioeconomic associations by using data from 21 cities. 10,515,494 single live birth records between 2014 2019 Guangdong Women Children Health Information System were included in study. Descriptive statistical methods used analyze trend...
PD-1 inhibitors have been routinely used to treat advanced non-small cell lung cancer (NSCLC) and significantly improved clinical outcomes. In this study, we aimed explore the influence of pretreatment fibrinogen-albumin ratio (FAR) on treatment response survival in NSCLC patients treated with first-line anti-PD-1 therapy plus platinum-based combination chemotherapy.A total 91 were included study. All received at least two cycles systemic chemotherapy. Receiver operating characteristics...
Genetic alterations, including the overexpression of epidermal growth factor receptor (EGFR), play a crucial role in ovarian carcinogenesis. To date, EGFR targeting has shown limited antitumor effects cancer when administered as monotherapy. We previously identified platelet-activating (PAFR) being overexpressed and found that its ligand PAF evoked phosphorylation. determine whether PAFR can enhance efficacy inhibition, we investigated antagonist (WEB2086) conjunction with an inhibitor...
Aim The present study aimed to assess the prevalence of potentially inappropriate medications (PIM) use in West China Hospital residents aged ≥65 years, using two sets criteria – Beers and Screening Tool Older Persons’ Prescriptions (STOPP) compare STOPP criteria, determine better for assessing PIM older adults China. Methods This was a retrospective cross‐sectional study, all patients were years admitted through Information Center from October 2010 April 2013. used identify PIM. A...
With the publication of Sepsis-3 definition, epidemiological data based on definition from middle-income countries including China are scarce, which prohibits understanding disease burden this newly defined syndrome in these settings. The purpose study was to describe incidence and outcome Yuetan sub-district Beijing estimate rate China.
Abstract Background Compared with viral vectors, nonviral vectors are less immunogenic, more stable, safer and easier to replication for application in cancer gene therapy. However, delivery system has not been extensively used because of the low transfection efficiency short transgene expression, especially vivo . It is desirable develop a that can support stable genomic integration persistent expression Here, we composite consisting piggyBac (PB) transposon polyethylenimine (PEI) long-term...
Ginkgolide B (GB), the primary active component of Ginkgo biloba extracts, may have antitumor properties. The objective this study was to determine effects and possible mechanisms GB in ovarian cancer cells. In study, human cell lines (SKOV3 CAOV3) were treated with different concentrations alone or combination Cis-diaminodichloroplatinum (CDDP). An MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay performed viability. apoptosis rates cells measured by flow cytometric...