A5009307433- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Nosocomial Infections in ICU
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Antifungal resistance and susceptibility
- Climate Change and Health Impacts
- Pneumocystis jirovecii pneumonia detection and treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumonia and Respiratory Infections
- Pulmonary Hypertension Research and Treatments
- Bacterial Identification and Susceptibility Testing
- Fungal Infections and Studies
- COVID-19 Clinical Research Studies
- Neonatal and Maternal Infections
- Tuberculosis Research and Epidemiology
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Neutropenia and Cancer Infections
- Non-Invasive Vital Sign Monitoring
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- Long-Term Effects of COVID-19
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2016-2025
Fujian Provincial Hospital
2025
Fujian Medical University
2025
Huzhou University
2025
Academy of Medical Sciences
2011-2024
Gansu Agricultural University
2024
Chengdu University of Traditional Chinese Medicine
2024
Tongren Hospital
2020-2023
Shanghai Jiao Tong University
2020-2023
Sepsis is a leading cause of preventable death around the world. Population-based estimation sepsis incidence lacking in China. In this study, we aimed to estimate population-based and geographic variation hospitalized China.We retrospectively identified from nationwide National Data Center for Medical Service (NDCMS) Mortality Surveillance System (NMSS) by ICD-10 codes period 2017 2019. In-hospital case fatality mortality rate were calculated extrapolate national sepsis. The distribution...
Abstract Objective This study aims to assess the relationship between NHHR (non-high-density lipoprotein cholesterol high-density ratio) and Type 2 diabetes mellitus (T2DM) in US adults, using National Health Nutrition Examination Survey (NHANES) data from 2007 2018. Methods explored connection T2DM by analyzing a sample reflecting adult population of United States ( n = 10,420; NHANES 2007–2018). was characterized as ratio non-high-density cholesterol. defined based on clinical guidelines....
ABSTRACT Management of airway infections caused by Pseudomonas aeruginosa is a serious clinical challenge, but little known about the microbial ecology in intubated patients. We analyzed bacterial diversity endotracheal aspirates obtained from patients colonized P. using 16S rRNA clone libraries and microarrays (PhyloChip) to determine changes community compositions during antibiotic treatment. Bacterial genes were absent briefly for elective surgery detected PCR samples all longer periods....
Abstract Objectives To evaluate the incidence and mortality of acute respiratory distress syndrome (ARDS) in medical/respiratory intensive care units (MICUs/RICUs) to assess ventilation management use adjunct therapy routine clinical practice for patients fulfilling Berlin definition ARDS mainland China. Methods This was a multicentre prospective longitudinal study. Patients who met were included. Baseline data on ventilator collected. Results Of 18,793 admitted participating ICUs during...
Left ventricular (LV) dysfunction is common in septic shock. Its association with the clinical outcome still controversial. Tissue Doppler imaging (TDI) a useful tool to quantify LV function; however, little knowledge available about prognostic value of these TDI variables Therefore, we performed this prospective study determine role shock.Patients shock medical intensive care unit were studied transthoracic echocardiography within 24 hours after onset Baseline clinical, laboratory, and...
Information about the epidemiology of sepsis in community residents China remains scarce and incomplete. The purpose this study was to describe occurrence rate outcome Yuetan Subdistrict Beijing estimate China.Retrospective cohort study.All public hospitals serving Subdistrict, Beijing.All patients (n = 1,716) meeting criteria for based on American College Chest Physicians/Society Critical Care Medicine consensus definition.None.We screened all adult who were hospitalized from July 1, 2012,...
Mutations in MEF2A have been implicated an autosomal dominant form of coronary artery disease (adCAD1). In this study we sought to determine whether severe mutations might also explain sporadic cases (CAD). To do this, resequenced the coding sequence and splice sites approximately 300 patients with premature CAD failed find causative cohort. However, did identify 21-bp deletion originally adCAD1 1 elderly control subjects without CAD. Further screening 1,500 additional individuals revealed 2...
Abstract Pancreatic ductal adenocarcinoma (PDAC) tumours exhibit a high level of heterogeneity which is associated with hypoxia and strong resistance to chemotherapy. The RNA splicing protein polypyrimidine tract‐binding 3 (PTBP3) regulates hypoxic gene expression by selectively binding hypoxia‐regulated transcripts. We have investigated the role PTBP3 in tumour development chemotherapeutic human PDAC tissues pancreatic cancer cells. In addition, we determined sensitivity cells gemcitabine...
OBJECTIVE: To determine whether mortality differed between initial invasive mechanical ventilation (IMV) or noninvasive (NIV) followed by delayed IMV in immunocompromised patients with sepsis. DESIGN: Retrospective analysis using the National Data Center for Medical Service claims data China from 2017 to 2019. SETTING: A total of 3530 hospitals across China. PATIENTS: 36,187 adult sepsis requiring ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary outcome was...
Introduction Patients with idiopathic inflammatory myopathies (IIMs) are sometimes complicated life-threatening conditions requiring intensive care unit (ICU) admission. In the past, owing to low incidence of IIM, little was known about such patients. Our aim investigate clinical features and outcomes these patients identify their risk factors for mortality. Methods A retrospective study performed IIM admitted over an 8-year period medical ICU a tertiary referral center in China. We...
<h3>BACKGROUND:</h3> High-flow nasal cannula (HFNC) is supposed to provide additional PEEP compared with conventional oxygen therapy. However, the exact determinants of this effect are unclear. We investigated factors that might affect and performance among 3 HFNC devices. <h3>METHODS:</h3> Three available devices were evaluated: AIRVO 2 device mechanical ventilators (SV300 Monnal T75). A consisting a test lung (5600i) an airway model (AMT(IE)) was used simulate spontaneous breathing. The...
Pneumocystis jiroveci pneumonia (PJP) in non-HIV patients is still a challenge for intensivists. The aim of our study was to evaluate mortality predictors PJP requiring Intensive care unit (ICU) admission. Retrospectively review medical records with diagnosis admitted four ICUs two academic centers from October 2012 2015. Eighty-two were enrolled the study. Overall hospital 75.6 %. Compared survivors, non-survivors had older age (55 ± 16 vs. 45 17, p = 0.014), higher APACHE II score (20 5 17...
Abstract Gemcitabine is first‐line chemotherapy for pancreatic cancer, however, the development of resistance limits its effectiveness. The tripartite motif‐containing 11 (TRIM11) protein plays crucial roles in tumor and undergoes auto‐polyubiquitination to promote interactions selective autophagy. Therefore, Understanding whether TRIM11 involved ferritinophagy gemcitabine cancer critical developing therapeutics. expression was validated by Western blot analysis, real‐time polymease chain...
The incidence of Pneumocystis pneumonia (PCP) among patients without human immunodeficiency virus (HIV) infection continues to increase. Here, we identified potential risk factors for in-hospital mortality HIV-negative with PCP admitted the intensive care unit (ICU).We retrospectively analyzed medical records 154 non-HIV-infected ICU at Peking Union Medical College Hospital (PUMCH) and China-Japan Friendship (CJFH) from October 2012 July 2020. Clinical characteristics were examined, related...
To identify the key genes and immunological pathways shared by type 2 diabetes mellitus (T2DM) chronic obstructive pulmonary disease (COPD) explore potential therapeutic targets of T2DM complicated COPD. GEO database was used for analyzing gene expression profiles in COPD to common differentially expressed (DEGs) two diseases. A protein-protein interaction network constructed candidate hub genes, which were validated datasets sets obtain target genes. The diagnostic accuracy these assessed...
Academic English writing is a crucial component of undergraduate education. However, undergraduates commonly face challenges such as unclear topic selection, imprecise language expression, and lack depth logical coherence in analysis argumentation. This study, grounded AGIL theory (Adaption, Goal Attainment, Integration, Latency Pattern Maintenance), integrates generative artificial intelligence with instant feedback to develop “Human-Computer Dual-Instructor” model for learning engagement...