A5101797624- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Intensive Care Unit Cognitive Disorders
- MicroRNA in disease regulation
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mechanical Circulatory Support Devices
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Cystic Fibrosis Research Advances
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
- Airway Management and Intubation Techniques
- Sepsis Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Hemodynamic Monitoring and Therapy
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- advanced mathematical theories
- Cancer, Hypoxia, and Metabolism
- Demographic Trends and Gender Preferences
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Infectious Aortic and Vascular Conditions
Beijing Anzhen Hospital
2007-2023
Capital Medical University
2008-2023
Capital University
2023
Beijing Institute of Water
2022
Bridge University
2013
Temple University
2005-2008
Shanghai First People's Hospital
2004
Utah AIDS Foundation
1987-1988
Abstract Objectives To evaluate the incidence and mortality of acute respiratory distress syndrome (ARDS) in medical/respiratory intensive care units (MICUs/RICUs) to assess ventilation management use adjunct therapy routine clinical practice for patients fulfilling Berlin definition ARDS mainland China. Methods This was a multicentre prospective longitudinal study. Patients who met were included. Baseline data on ventilator collected. Results Of 18,793 admitted participating ICUs during...
Background Although noninvasive positive pressure ventilation (NPPV) has been successfully used for various kinds of acute respiratory failure, the data are limited regarding its application in postoperative failure after cardiac surgery. Therefore, we conducted a prospective randomized control study university surgical intensive care unit to evaluate efficacy and safety NPPV treatment surgery, explore predicting factors failure. Methods From September 2011 November 2012 patients with...
Inflammation plays a pivotal role in the development of pulmonary arterial hypertension (PAH). Meanwhile, serum glucocorticoid-regulated kinase-1 (SGK1) has been considered to be an important factor regulation inflammation some vascular disease. However, SGK1 hypoxia-induced and PAH is still unknown. WT -/- mice were exposed chronic hypoxia induce PAH. The quantitative PCR immunohistochemistry used determine expression SGK1. right ventricular hypertrophy index (RVHI), RV/BW ratio, ventricle...
Abstract Background Cardiopulmonary bypass (CPB) can lead to lung injury and even acute respiratory distress syndrome (ARDS) through triggering systemic inflammatory response. The objective of this study was investigate the impact CPB time on clinical outcomes in patients with ARDS after cardiac surgery. Methods Totally, surgery Beijing Anzhen Hospital from January 2005 December 2015 were retrospectively included further divided into three groups according median CPB. primary endpoints ICU...
Low-density gas mixtures, such as heliox, were shown to reduce the work of breathing and facilitate distribution inspired gas. Since supplemental ventilatory oxygen requirements may lead pulmonary inflammation structural alterations, we hypothesized that by reducing these requirements, heliox attenuate acute inflammatory changes associated with lung injury. Spontaneously neonatal pigs anesthetized, instrumented, supported continuous positive airway pressure (CPAP), injured oleic acid,...
Pulmonary arterial hypertension (PAH) is a progressive and complex pulmonary vascular disease with poor prognosis. The aim of this study was to provide new understanding the pathogenesis potential treatment targets for patients PAH based on multiple-microarray analysis.Two microarray datasets (GSE53408 GSE113439) downloaded from Gene Expression Omnibus (GEO) database were analysed. All raw data processed by R, differentially expressed genes (DEGs) screened out "limma" package. Ontology (GO)...
The aim of the present study was to investigate role microRNA‑15a‑5p (miR‑15a‑5p) in pulmonary arterial hypertension (PAH) and elucidate underlying pro‑apoptotic mechanism. Reverse transcription‑quantitative PCR analysis gene microarray hybridization were used measure expression miR‑15a‑5p lung tissues rats with monocrotaline (MCT)‑induced PAH. Flow cytometry caspase‑3/9 activity assays adopted apoptosis artery smooth muscle cells (PASMCs). apoptosis‑related proteins analyzed using western...
Pulmonary arterial hypertension (PAH) is a clinical hemodynamic syndrome. It characterized by elevated PA pressure and pulmonary vascular resistance. In the present study, role of microRNA (miRNA/miR)‑371b‑5p in monocrotaline‑induced PAH underlying mechanisms were investigated. rat model, gene chip reverse transcription‑quantitative polymerase chain reaction employed to measure miRNA expression levels. The results revealed that miR‑371b‑5p was downregulated rats compared with control group....
Background Although severe encephalopathy has been proposed as a possible contraindication to the use of noninvasive positive-pressure ventilation (NPPV), increasing clinical reports showed it was effective in patients with impaired consciousness and even coma secondary acute respiratory failure, especially hypercapnic failure (HARF). To further evaluate effectiveness safety NPPV for encephalopathy, prospective case-control study conducted at university intensive care unit (RICU)...
Background Despite advances in treatment strategies, acute respiratory distress syndrome (ARDS) after cardiac surgery remains associated with high morbidity and mortality. A method of screening patients for risk ARDS is needed. Objectives To develop validate an prediction score designed to identify at or aortic surgery. Methods An was derived from a retrospective derivation cohort validated prospective cohort. Discrimination calibration the were assessed area under receiver operating...
Whether procalcitonin (PCT) or C-reactive protein (CRP) combined with certain clinical characteristics can better distinguish viral from bacterial infections remains unclear. The aim of the study was to assess ability PCT CRP between and in hospitalized non-intensive care unit (ICU) adults lower respiratory tract infection (LRTI).This a post-hoc analysis randomized trial previously conducted among LRTI patients. PCT, symptoms discriminate were assessed by portraying receiver operating...
To examine the hypothesis that combined treatment with tracheal gas insufflation (TGI) and partial liquid ventilation (PLV) may improve pulmonary outcome relative to either alone in acute lung injury (ALI), saline lavage was induced 24 anesthetized, ventilated juvenile rabbits were then randomly assigned receive ( n = 6/group) 1) conventional mechanical (CMV) alone, 2) continuous TGI at 0.5 l/min, 3) PLV perfluorochemical liquid, 4) (TGI + PLV), subsequently minimized pressures tidal volume...
BACKGROUND The "obesity paradox" exists in many diseases. It is unclear whether it also acute respiratory distress syndrome (ARDS). purpose of our study was to clarify the relationship between obesity and development hospital mortality from ARDS among patients who underwent cardiac surgery. MATERIAL AND METHODS This retrospective case-control included 202 with 808 matching without ARDS. We clarified after adjusting for confounding factors by multiple logistic regression analysis. A total...
Objectives. Acute lung injury (ALI) is a common clinical critical disease. Stem cells transplantation recognized as an effective way to repair injured tissues. The present study was designed evaluate the effects of mesenchymal stem (MSCs) on and its mechanism. Methods. MSCs carrying GFP were administrated via trachea into wild-type SD rats 4 hours later after LPS administration. histological pathology distribution determined by HE staining fluorescence microscopy, respectively. Next,...
Purpose: To establish a model to predict the risk of acute respiratory distress syndrome (ARDS) after cardiac surgery. Methods: Data were collected on 132 ARDS patients, who received valvular or coronary artery bypass grafting surgery from January 2009 December 2019. We developed prediction by multivariable logistic regression. Then, we used coefficients for developing nomogram that predicts occurrence. Internal validation was performed using resampling techniques evaluate and optimize...
Acute respiratory failure (ARF) has a high mortality rate, and currently, there is no convenient risk predictor. The coagulation disorder score was proven to be promising metric for predicting in-hospital mortality, but its role in ARF patients remains unknown.In this retrospective study, data were extracted from the Medical Information Mart Intensive Care IV (MIMIC-IV) database. Patients diagnosed with hospitalized more than 2 days at their first admission included. defined based on...
Background Exposure of adult mice to more than 95% O 2 produces a lethal injury by 72 hours. Nuclear factor kappa B (NF-κB) is transcriptional that plays key role in the modulation cytokine networks during hyperoxia-induced acute lung (ALI). Osteopontin (OPN) phosphorylated glycoprotein produced principally macrophages. Studies have reported exogenous OPN can maintain integrity cerebral microvascular basement membrane and reduce brain damage through inhibiting NF-κB activities after...
Objective: To investigate the effect of obstructive sleep apnea (OSA) on severity acute pulmonary thromboembolism (PTE). Methods: Clinical data patients with PTE and OSA who were admitted to Anzhen Hospital from January 2015 December 2017 retrospectively analyzed in this study.According hypopnea index (AHI), divided into AHI≤15/h group AHI>15/h group. The levels oxygen desaturation (ODI), mean pulse saturation (MSO(2)), lowest (LSaO(2)), saturation<90% time ratio (Ts90%), hemoglobin,...
Although obstructive sleep apnoea (OSA) is prevalent among patients with aortic dissection, its prognostic impact not yet determined in undergoing major vascular surgery. We aimed to investigate the association of OSA hypoxaemia and prolonged intensive care unit (ICU) stay after type A dissection (TAAD) repair.This retrospective study continuously enrolled 83 who underwent TAAD repair from January 1 December 31, 2018. was diagnosed by test defined as an hypopnea index (AHI) ≥ 15/h, while AHI...
Acute respiratory distress syndrome (ARDS) is a leading cause of death in critically ill patients due to hypoxemic failure. The specific pathogenesis underlying ARDS has not been fully elucidated. In this study, we constructed triple regulatory network involving competing endogenous RNA (ceRNA) investigate the potential mechanism and evaluated immune cell infiltration patterns patients. Overall, downloaded three microarray datasets that included 60 with sepsis-induced 79 sepsis alone from...
Perfluorochemical (PFC) liquids have been shown to support lung function, uniformly distribute rhSOD and attenuate biomarkers of oxidative damage inflammation in a juvenile model acute injury. The impact this approach on injury the immature has not evaluated. To test hypothesis that intratracheal PFC augmented delivery will injury, preterm lambs (n = 18; 123.4 ± 1.4 days gestation) were ventilated, surfactant-treated. Lambs then randomized receive (5 mg/kg) saline 6) or 6), 3), surfactant...
Background Pulmonary surfactant dysfunction may contribute to the development of ventilator induced lung injury (VILI). Tracheal gas insufflation (TGI) is a technique in which fresh introduced into trachea and augment ventilation by reducing dead space ventilatory system, pressures tidal volume (VT) while maintaining constant partial arterial CO2 pressure (PaCO2). We hypothesised that TGI limited peak inspiratory (PIP) VT would minimize conventional mechanical (CMV) pulmonary thereby...