A5100456052- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Lipoproteins and Cardiovascular Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Plant-based Medicinal Research
- Drug Transport and Resistance Mechanisms
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Acute Kidney Injury Research
- Cardiac electrophysiology and arrhythmias
- Inflammasome and immune disorders
- Genetic factors in colorectal cancer
- Viral Infections and Immunology Research
- Cancer, Lipids, and Metabolism
- Computational Drug Discovery Methods
- Bioactive Natural Diterpenoids Research
- Autoimmune and Inflammatory Disorders Research
- Adenosine and Purinergic Signaling
- Cholesterol and Lipid Metabolism
- Lipid metabolism and disorders
- Drug-Induced Hepatotoxicity and Protection
- Cancer Mechanisms and Therapy
- Phytochemistry and biological activities of Ficus species
China-Japan Friendship Hospital
2015-2025
Jinan Central Hospital
2024-2025
Shandong First Medical University
2024-2025
Shandong University
2024
Hebei Medical University
2024
Xingtai People's Hospital
2024
Xingtai Medical College
2024
Academy of Medical Sciences
2024
Xinxiang Medical University
2024
New Orleans Public Library
2022
Abstract Objectives To evaluate the incidence and mortality of acute respiratory distress syndrome (ARDS) in medical/respiratory intensive care units (MICUs/RICUs) to assess ventilation management use adjunct therapy routine clinical practice for patients fulfilling Berlin definition ARDS mainland China. Methods This was a multicentre prospective longitudinal study. Patients who met were included. Baseline data on ventilator collected. Results Of 18,793 admitted participating ICUs during...
Objective: This study explores the potential causal association between proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors and tumor development using Mendelian randomization (MR) based on drug targets. Methods: Instrumental variables within ±100 kb of PCSK9 gene locus, impacting low-density lipoprotein cholesterol (LDL-C), were utilized for MR analysis. Coronary heart disease (CHD) served as a positive control to validate relationship various cancers. We employed reverse address...
The global aging trend exacerbates the challenge of frailty and cognitive impairment in older adults, yet their combined impact on health outcomes remains under-investigated. This study aims to explore how psychometric mild (pMCI) jointly affect all-cause cardiovascular disease (CVD) mortality. cohort we examined 2,442 participants aged ≥ 60, is secondary analysis from National Health Nutrition Examination Survey (NHANES) 2011–2014. Frailty was quantified using a 49-item index, while pMCI...
This study investigated the proteomic landscape of exfoliation glaucoma to find potential biomarkers. The enrolled 34 patients diagnosed with either syndrome with/without or age-related cataract. Plasma proteins were analyzed through mass spectrometry and Mendelian randomization (MR) based on data from deCODE, FinnGen, Atherosclerosis Risk in Communities (ARIC), eQTLGen, UK Biobank (UKB) cohorts infer relationships. Among 2025 plasma analyzed, 130 differentially expressed group, which...
As an important part of the comprehensive treatment methods, urate-lowering Chinese herbs could provide favorable clinical effects on hyperuricemia in its ability to invigorate spleen and remove dampness. Owing long-term duration, it brought up potential adverse reactions (ADRs) concerns about drug-induced liver injury from these herbs. To address this problem, bioinformatics approaches which combined network pharmacology, computer simulation molecular biology experiments were undertaken...
The JAK2-STAT signaling pathway plays a critical role in myeloproliferative neoplasms (MPN). An activating mutation JAK2 (V617F) is present ~ 95% of polycythemia vera, essential thrombocythemia, and primary myelofibrosis cases. This study aims to explore the selective JAK2V617F inhibitor, evaluate efficacy possible mechanism ZT55 on MPN.HTRF assays were conducted inhibition for JAKs. Cell apoptosis, proliferation, cycle arrest performed examine effect HEL cell line with vitro. Western...
Objectives Acute kidney injury (AKI) is a common complication after lung transplantation (LTx) which closely related to the poor prognosis of patients. We aimed explore potential risk factors and outcomes associated with early post-operative AKI LTx.Methods A retrospective study was conducted in 136 patients who underwent LTx at our institution from 2017 2019. defined according Kidney Disease: Improving Global Outcomes (KDIGO) guideline. Univariate multivariate analyses were identify AKI....
Carbapenem pharmacokinetic (PK) profiles are significantly different in critically ill patients because of the drastic variability patients' physiological parameters. Published population PK studies have mainly focused on specific diseases, and majority these had small sample sizes. The aim this study was to develop a model imipenem that estimated influence various clinical biological covariates use extracorporeal membrane oxygenation (ECMO) continuous renal replacement therapy (CRRT). A...
Abstract The determination of the appropriate initial dose for tacrolimus is crucial in achieving target concentration promptly and avoiding adverse effects poor prognosis. However, trial‐and‐error approach still common practice. This study aimed to establish a prediction model an dosing algorithm patients receiving lung transplant. A total 210 transplant recipients were enrolled, 26 single nucleotide polymorphisms (SNP) from 18 genes that could potentially affect pharmacokinetics genotyped....
As hypertensive heart disease (HHD) presents a significant public health challenge globally, we analysed its global, regional, and national burdens trends from 1990 to 2019.
This study aimed to develop a nomogram for predicting persistent renal dysfunction in acute kidney injury (AKI) following lung transplantation (LTx). A total of 229 LTx patients were enrolled, and genotyping 153 single nucleotide polymorphisms (SNPs) was performed. The cohort randomly divided into training (n = 183) validation 46) sets an 8:2 ratio. Statistically significant SNPs identified through pharmacogenomic analysis combined with clinical factors construct comprehensive prediction...
Chinese materia medica (CMM) has been widely used as an approach of ethnomedicine worldwide. Recently, there are growing concerns related to the potential cardiotoxicity herbal medicines but comprehensive studies limited.Comprehensive literature retrieval via publicly available electronic databases was performed identify case reports that focused on cardiac adverse reactions (ADRs) triggered by oral CMMs. And a bibliometric survey conducted analyze most commonly suspected risk factors in...
Rivaroxaban is a popular direct factor Xa inhibitor used for anticoagulation therapy in patients with nonvalvular atrial fibrillation (NVAF). The aim of this study was to establish population pharmacokinetic (PPK) model rivaroxaban elderly Chinese fibrillation, evaluate precision dosing regimens, and analyze hemorrhagic risk after treatment. A 1-compartment PK estimated glomerular filtration rate (eGFR), total bilirubin (TBIL), ABCB1 rs1045642 as major covariates apparent clearance developed...
To analyze the trend of prevalence and major risk factors for diabetes between 1997 2009 in Shenzhen.A total sample 7956 8487 residents aged from 20 to 69 years were selected using multi-stage cluster sampling two cross-sectional chronic diseases survey Shenzhen respectively. The variation different age groups (divided into a 5-year group) compared. effect was evaluated by population attributable percentage (PARP), time PARP analyzed.Compared with that 1997, aged-adjusted has increased 3.85%...
Abstract Background : Angina pectoris (AP), characterized by retrosternal chest pain, pressure, or discomfort, serves as a prognostic indicator for significant cardiac adverse events and has been associated with numerous inflammatory mechanisms in prior research. Nevertheless, the precise causal connection between AP diverse circulating proteins remains inadequately elucidated. Methods: This study used thorough two-sample Mendelian randomization analysis to determine link blood AP. We public...
The purpose of this study was to investigate the correlation between different subtypes acute kidney injury (AKI) and clinical outcomes following lung transplantation (LTx) identify a reliable indicator for predicting poor prognosis in LTx population.