A5102007113- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Cancer-related molecular mechanisms research
- Hormonal and reproductive studies
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Advanced Radiotherapy Techniques
- Bladder and Urothelial Cancer Treatments
- Urinary Bladder and Prostate Research
- Cancer Cells and Metastasis
- Advanced Proteomics Techniques and Applications
- Plant Gene Expression Analysis
- Radiopharmaceutical Chemistry and Applications
- Urological Disorders and Treatments
- Renal and Vascular Pathologies
- Anatomy and Medical Technology
- Enhanced Recovery After Surgery
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
Changhai Hospital
2015-2024
Second Military Medical University
2015-2024
Zhengzhou University
2024
Research Institute of Forestry
2024
Chinese Academy of Forestry
2024
Yunnan University
2024
People's Hospital of Bishan District
2021-2023
Chongqing Medical University
2021-2023
Yangzhou University
2022
China International Science and Technology Cooperation
2021
Ferroptosis is a new form of regulated cell death, which mediated by intracellular iron. Although it reported that bavachin has antitumour effects on several tumour cells and prompts the reactive oxygen species (ROS) generation, unclear whether ferroptosis can be induced in osteosarcoma (OS) cells. In this study, we found inhibits viability MG63 HOS OS lines along with an increase ferrous iron level, ROS accumulation, malondialdehyde overexpression, glutathione depletion. Moreover, chelators...
The androgen receptor (AR) is required for castration-resistant prostate cancer (CRPC) progression, but the function and disease relevance of AR-bound enhancers remain unclear. Here, we identify a group AR-regulated enhancer RNAs (e.g., PSA eRNA) that are upregulated in CRPC cells, patient-derived xenografts (PDXs), patient tissues. eRNA binds to CYCLIN T1, activates P-TEFb, promotes cis trans target gene transcription by increasing serine-2 phosphorylation RNA polymerase II (Pol II-Ser2p)....
Purpose: Cancer stem-like cells (CSC) contribute to the progression and androgen deprivation therapy (ADT) resistance of prostate cancer. As CSCs depend on their specific niche, including tumor-associated macrophages (TAM), elucidating network between TAMs may help effectively inhibit ADT cancer.Experimental Design: The underlying intracellular mechanism that sustains characteristics in cancer was assessed via RNA sequencing, co-immunoprecipitation, chromatin immunoprecipitation, other...
Purpose: Androgen deprivation therapy (ADT), including enzalutamide, induces resistance in prostate cancer; ADT is associated with neuroendocrine differentiation (NED) and tumor-associated macrophages (TAM). This study aimed to investigate the association between enzalutamide-induced NED TAMs its mechanism.Experimental Design: The was investigated by IHC using cancer tissues, enzalutamide-resistant mouse xenografts, a coculture system. underlying mechanisms were assessed vitro cytokine...
Rubus idaeus is a pivotal cultivated species of raspberry known for its attractive color, distinct flavor, and numerous health benefits. It can be used in pharmaceutical, cosmetics, agriculture food industries not only as fresh but also processed product. Nowadays due to climatic changes, genetic diversity cultivars has decreased dramatically. However, until now, the status wild R. resources China have been exploited. In this study, we investigated secure future potential sustainability. The...
A number of biomarkers have been identified for various cancers. However, associated with glioma remain largely to be explored. In the current study, we investigated relationship between expression and prognostic value HIST1H2BK gene in glioma. Sequential data filtering (survival analysis, independent ROC curve clinical correlation analysis) was performed, which resulted identification association Then, analyzed using bioinformatics (Kaplan–Meier survival univariate Cox multivariate...
To compare the peri-operative and early renal functional outcomes of robot-assisted partial nephrectomy (RAPN) laparoscopic (LPN) for kidney tumours.A total 237 patients fulfilling selection criteria were included, whom 146 91 treated with LPN RAPN, respectively. adjust potential baseline confounders, propensity-score matching was performed. A favourable outcome defined as a warm ischaemia time (WIT) ≤20 min, negative surgical margins, no conversion, Clavien ≥3 complications postoperative...
Increasing evidence reveals that the interaction between tumor cells and tumor-associated macrophages (TAMs) facilitates progression of prostate cancer, but related mechanisms remained unclear. This study determined how gankyrin, a component 19S regulatory complex 26S proteasome, regulates androgen deprivation therapy (ADT) resistance cancer through cell-TAM interactions. In vitro functional experiments in vivo subcutaneous models were used to explore biological role molecular gankyrin 234...
To explore the effect of 3-dimensional (3D) printing-assisted cognitive fusion on improvement positive rate in prostate biopsy.From August to December 2014, 16 patients with suspected prostatic lesions detected by multiparametric magnetic resonance imaging (MRI) were included. Targeted biopsy was performed use 3D reconstruction modeling, computer-simulated biopsy, printing, and biopsy. All had received 3.0 T MRI before The DICOM files imported medical processing software for modeling...
Prostate cancer antigen 3 (PCA3) is a biomarker for diagnosing prostate (PCa) identified in the Caucasian population. We evaluated effectiveness of urinary PCA3 predicting biopsy result 500 men undergoing initial biopsy. The predictive power score was by area under receiver operating characteristic (ROC) curve (AUC) and decision analysis. sufficed to discriminate positive from negative results but not correlated with aggressiveness PCa. ROC analysis showed higher AUC than %fPSA (0.750 vs...
Objectives To compare the perioperative and early renal functional outcomes of RPN with OPN for kidney tumors. Materials Methods A total 209 or patients availability preoperative cross-sectional imaging since 2009 at our center were included. adjust potential baseline confounders propensity-score matching was performed, which resulted in 94 OPNs matched to 51 RPNs. Perioperative compared. Results In analysis, procedures well tolerated significant decreases postoperative analgesic time (24...
Cell lineage reprogramming is the main approach for cancer cells to acquire drug resistance and escape targeted therapy. The use of potent therapies in cancers has led development highly aggressive carcinoma, including neuroendocrine prostate (NEPC). Although metabolic been reported be essential tumor growth energy production, relationship between differentiation which can cause hormone therapy never (PCa). Moreover, as there still no efficient NEPC, it urgent reverse this during Here first...
Background The malignant mesothelioma (MM) survival rate has been hampered by the lack of efficient and accurate early detection methods. immune system may detect changes tumor progression responding with tumor-associated autoantibody production. Hence, in this study, we translated humoral response to cancer proteins into a potential blood test for MM. Methodology/Principal Findings A T7 phage MM cDNA library was constructed using tissues biopanned antigens (TAAs) pooled patient normal serum...
To summarize the experience of first 500 robot-assisted laparoscopic radical prostatectomy (RALP) cases by one surgeon and analyze influencing factors functional oncological outcomes.Between April 2012 October 2017, patients who underwent RALP were included divided sequentially into five equal groups. Patients' preoperative, perioperative postoperative outcomes analyzed evaluated, Kruskal-Wallis test was used to compare effect case.There is a statistically significant reduction in operative...
OBJECTIVETo develop and validate a novel perineal nerve block approach for transperineal prostate biopsy.PATIENTS AND METHODSFive adult male cadavers were dissected to delineate the superficial deep branches of nerve. Afterwards, 90 out 115 patients selected randomly assigned receive periprostatic, periapical triangle, or (BPN) block. The primary outcome was maximal pain intensity associated with biopsy, which assessed by 10-point visual analog scale. secondary outcomes included number...
Intratumor heterogeneity is a key driver for local relapse and treatment failure. Thus, using multifocal prostate cancer as model to investigate tumor inter-clonal relationships evolution could aid in our understanding of drug resistance. Previous studies discovered genomic alterations by comparing hormone-sensitive (HSPC) with castration-resistant (CRPC) large cohorts. However, most did not sequentially sample tumors from the same patient. In study, we performed whole-exome sequencing (WES)...
Abstract Background Radical prostatectomy remains the fundamental treatment for prostate cancer, and improving patients’ compliance with postoperative follow-ups is essential quality of life. This study investigates effect education levels on recovery follow-up after radical prostatectomy. Methods Data from 1,112 patients undergoing between 2011 2020 were collected using medical records, “pc-follow” systems used to collect baseline information, level, pathological number outpatient visits,...
Abstract Background and Objectives Patients with renal cell carcinoma (RCC) frequently have tumor thrombus of the vein or inferior vena cava (IVC). During radical nephrectomy, may become dislocated due to manipulation IVC during isolation, which result in pulmonary embolism. Placement filters at proximal end successfully prevented We herein report use Tempofilter II, a temporary filter for prevention Methods From 2006 2008, seven patients RCC level II III received nephrectomy resection...
// Yifan Chang 1, * , Rui Chen Qingsong Yang 2, Xu Gao 1 Chuanliang Jianping Lu 2 Yinghao Sun Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China Radiology, These authors contributed equally to this work Correspondence to: Sun, email: sunyhsmmu@126.com Lu, cjr.lujianping@vip.163.com Keywords: biopsy, diagnosis, multiparametric MRI, peripheral zone volume ratio, prostate cancer Received: June 13, 2016 Accepted:...