A5030194561- Erythrocyte Function and Pathophysiology
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- NF-κB Signaling Pathways
- Neonatal Health and Biochemistry
- FOXO transcription factor regulation
- Blood properties and coagulation
- Immune Cell Function and Interaction
- Rheumatoid Arthritis Research and Therapies
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Signaling Pathways in Disease
- Histone Deacetylase Inhibitors Research
- interferon and immune responses
- RNA modifications and cancer
- Kruppel-like factors research
- Cell death mechanisms and regulation
- Inflammatory mediators and NSAID effects
- Tea Polyphenols and Effects
- Connexins and lens biology
- Inflammasome and immune disorders
- Hippo pathway signaling and YAP/TAZ
- Venous Thromboembolism Diagnosis and Management
Fudan University
2025
Xichang University
2025
Sichuan University
2024
West China Hospital of Sichuan University
2024
Hunan University
2022-2024
Yunnan University
2009-2024
Hebei Normal University of Science and Technology
2024
Ministry of Education of the People's Republic of China
2010-2023
Changsha Medical University
2022-2023
Second People's Hospital of Yunnan Province
2019-2023
Loss-of-function mutations of phosphatase/tensin homolog deleted on chromosome 10 (PTEN)-induced putative kinase 1 (Pink1) (also known as Park6) identified in familial forms Parkinson's disease (PD) are associated with compromised mitochondrial function. Emerging data suggest that Pink1 is an essential pro-survival factor induced response to oxidative stress. However, the mechanisms regulating expression under stress conditions remain unknown. Forkhead box, subgroup O (FOXO) transcription...
Myelodysplastic syndromes (MDS) are age-related myeloid neoplasms with increased risk of progression to acute leukemia (AML). The mechanisms transformation MDS AML poorly understood, especially in relation the aging microenvironment. We previously established an mDia1/miR-146a double knockout (DKO) mouse model phenocopying MDS. These mice develop pancytopenia oversecretion proinflammatory cytokines. Here, we found that most DKO underwent leukemic at 12-14 months age. showed myeloblast...
Anemia is characteristic of myelodysplastic syndromes (MDS). The mechanisms anemia in MDS are unclear. Using a mouse genetic approach, here we show that dual deficiency mDia1 and miR-146a, encoded on chromosome 5q commonly deleted (del(5q) MDS), causes an age-related ineffective erythropoiesis mimicking human MDS. We demonstrate the ageing bone marrow microenvironment important for development these mice. Damage-associated molecular pattern molecules (DAMPs), whose levels increase marrow,...
Rubus idaeus is a pivotal cultivated species of raspberry known for its attractive color, distinct flavor, and numerous health benefits. It can be used in pharmaceutical, cosmetics, agriculture food industries not only as fresh but also processed product. Nowadays due to climatic changes, genetic diversity cultivars has decreased dramatically. However, until now, the status wild R. resources China have been exploited. In this study, we investigated secure future potential sustainability. The...
The biological function of Tripartite Motif 39 (TRIM39) remains largely unknown. In this study, we report that TRIM39 regulates the steady-state levels p21 and is a pivotal determinant cell fate. Ablation leads to destabilization increased G1/S transition in unperturbed cells. Furthermore, DNA damage-induced accumulation completely abolished cells with depleted TRIM39. As result, silencing abrogates G2 checkpoint induced by genotoxic stress, leading mitotic entry and, ultimately, apoptosis....
To ensure genome stability, DNA must be replicated once and only during each cell cycle. Cdt1 is tightly regulated to make sure that cells do not rereplicate their DNA. Multiple regulatory mechanisms operate degradation of in S phase. However, little known about the positive regulators under physiological conditions. Here we identify FOXO3 as a binding partner Cdt1. forms protein complex with Cdt1, which turn blocks its interaction DDB1 PCNA. Conversely, depletion facilitated proteolysis...
Neuroblastoma is a common childhood malignant tumor originated from the neural crest-derived sympathetic nervous system. A crucial early event in neuroblastoma pathogenesis arrested differentiation of neuroblasts at various stages. Treatment with TPA and PDGF-BB leads to terminal cells. However, signaling pathways that are involved this process remain largely unknown. Here, we report inhibition endogenous FOXO proteins attenuated TPA/PDGF-BB mediated Activated transcription factors acted on...
V617F driver mutation of JAK2 is the leading cause Philadelphia-chromosome-negative myeloproliferative neoplasms (MPNs). Although thrombosis a mortality and morbidity in MPNs, mechanisms underlying their pathogenesis are unclear. Here, we identified pleckstrin-2 (Plek2) as downstream target JAK2/STAT5 pathway erythroid myeloid cells, showed that it upregulated JAK2V617F-positive MPN mouse model patients with MPNs. Loss Plek2 ameliorated JAK2V617F-induced phenotypes including erythrocytosis,...
The orbitofrontal cortex (ORB) exhibits a complex structure and diverse functional roles, including emotion regulation, decision-making, reward processing. Structurally, it comprises three distinct regions: the medial part (ORBm), ventrolateral (ORBvl), lateral (ORBl), each with unique attributes, such as ORBm’s involvement in processing, ORBvl’s regulation of depression-like behavior, ORBl’s response to aversive stimuli. Dysregulation ORB has been implicated various psychiatric disorders....
Cancer cells rely on lipogenesis in addition to exogenous lipid uptake, and fatty acid synthase (FASN) is aberrantly overexpressed myeloid leukemia. However, the precise role of FASN leukemogenesis vivo remains elusive. Here, we demonstrated that essential for leukemogenesis. Ablation impeded leukemic cell growth, survival, clonogenicity vitro, burden vivo. Conditional knockout barely affected hematopoiesis but significantly attenuated progression MLL-AF9 transplants. By screening a library...
Bacterial leaf blight (BLB) is a destructive disease caused by Xanthomonas oryzae pv. (Xoo). It has been proven that BLB adversely influences the growth and production of rice, resulting in substantial losses yield. Nanoparticle–antimicrobial compounds possess excellent physicochemical properties, which have generated groundbreaking applications protecting rice against attacks. However, there less research focused on interaction between nanoparticles microbiome leaves, particularly structure...
Differentiation of erythroblasts to mature red blood cells involves dynamic changes the membrane and cytoskeleton networks that are not fully characterized. Using a mouse fetal liver erythroblast culture system targeted shRNA functional screening strategy, we identified critical role pleckstrin-2 in actin dynamics protection early stage terminal from oxidative damage. Knockdown erythropoiesis disrupted led differentiation inhibition apoptosis. This pro-survival function was mediated through...
The formin protein mDia2 plays a critical role in number of cellular processes through its ability to promote nucleation and elongation actin filaments. In erythroblasts, this includes control cytokinesis enucleation by regulating contractile ring formation. Here we report novel mechanism how is regulated: acetylation deacetylation at lysine 970 the homology 2 domain. Ectopic expression an acetyl-mimic mutant mouse erythroblasts sufficient abolish formation cleavage furrow subsequent...
β-amyloid (Aβ) aggregation plays an important role in the pathogenesis of Alzheimer's disease (AD), and astrocytes can significantly inhibit Aβ aggregation. Astrocytic α7 Neuronal Nicotinic Acetylcholine Receptor (nAChR) upregulation detected AD brains is closely associated with deposits. However, relationships between astrocytic nAChRs remain unclear.The oligomers levels cell lysates culture medium were measured after treatment nicotine or co-treatment a Phosphatidylinositol 3-Kinase...
<title>Abstract</title> <italic>RET</italic>-rearranged spindle cell tumors represent a group of soft tissue with heterogeneous clinical presentations. While some are benign, others display malignant behavior metastatic potential. The underlying causes this heterogeneity unknown but suspected to be associated the diverse fusion partner genes involved in <italic>RET</italic> rearrangements. We describe unique case tumor an <italic>MYH10::RET</italic> that originated knee and metastasized...
Abstract Mammalian terminal erythropoiesis involves several characteristic phenomena including chromatin condensation and enucleation. One of the newly identified features in mouse is a dynamic nuclear opening histone release process, which required for condensation. However, it unclear whether same feature present human. Here, we use an vitro human CD34‐positive hematopoietic stem progenitor cell culture system reveal that openings are also during erythropoiesis. In contrast to each...