A5100462182- Cancer Genomics and Diagnostics
- Plant tissue culture and regeneration
- Genomics and Rare Diseases
- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Ovarian function and disorders
- Genomics and Phylogenetic Studies
- Ovarian cancer diagnosis and treatment
- Endoplasmic Reticulum Stress and Disease
- Genetic Associations and Epidemiology
- Rheumatoid Arthritis Research and Therapies
- interferon and immune responses
- NF-κB Signaling Pathways
- Plant Pathogens and Fungal Diseases
- RNA regulation and disease
- Metalloenzymes and iron-sulfur proteins
- Reproductive Biology and Fertility
Second Affiliated Hospital of Fujian Medical University
2024-2025
Fujian Medical University
2024-2025
Eastern Liaoning University
2024
Shenzhen Technology University
2021
Sinotech Genomics (China)
2020-2021
Anhui Medical University
2020
Eye & ENT Hospital of Fudan University
2019
Science and Technology Commission of Shanghai Municipality
2019
Abstract Accurate detection of low frequency mutations from plasma cell-free DNA in blood using targeted next generation sequencing technology has shown promising benefits clinical settings. Duplex is the most commonly used approach liquid biopsies. Unique molecular identifiers are attached to each double-stranded template, followed by production low-error consensus sequences detect variants. However, high costs have hindered application this practice. Here, we developed an improved duplex...
<i>Taxus cuspidata</i> is a rare plant with important medicinal and ornamental value. Aiming at the obvious differences between wild cultivated populations of <i>T. from Northeast China, total 61 samples, that is, 33 yews 28 were used to analyze correlations kinship, genetic diversity, structure them by specific length amplified fragment sequencing (SLAF-seq). Finally, 470725 polymorphic SLAF tags 58622 valid SNP markers obtained. Phylogenetic analysis showed samples classified into 2...
Background Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with various contributing factors. Understanding the molecular mechanisms underlying PCOS essential for developing effective treatments. This study aimed to identify hub genes and investigate potential associated through combination of bioinformatics analysis Mendelian randomization (MR). Methods employed in conjunction MR methods using publicly available databases genes. We complementary methods, including...
Purpose: To explore a method for the early, rapid and accurate diagnosis of Wolfram syndrome 1 (WS1) further enrich spectrum WFS1 mutations in Chinese population. Methods: We analyzed 279 patients with unexplained optic atrophy using next-generation sequencing. All underwent detailed clinical evaluations. Furthermore, Sanger sequencing cosegregation analyses were performed within families. Results: Five WS1 identified four unrelated families, their features reviewed detail. Seven variants...
The ability to rapidly, inexpensively, and accurately identify cancer patients based on actionable genomic mutations in tumour specimens is becoming critically important routine clinical diagnostics. Targeted panel sequencing popular because it enables comprehensive cost-effective diagnosis. However, the implementation of a next-generation (NGS) assay settings requires careful analytical validation demonstrate its detect multiple variants.Here, we developed custom-targeted NGS variants,...