A5014394014- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Acute Myeloid Leukemia Research
- Plant nutrient uptake and metabolism
- Cancer-related gene regulation
- Plant Micronutrient Interactions and Effects
- DNA Repair Mechanisms
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Cytokine Signaling Pathways and Interactions
- Photosynthetic Processes and Mechanisms
- Virus-based gene therapy research
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- Phytoplasmas and Hemiptera pathogens
- Cardiac tumors and thrombi
- Autophagy in Disease and Therapy
- Melanoma and MAPK Pathways
Yunnan University
2022-2024
Ionis Pharmaceuticals (United States)
2020
Sylvester Comprehensive Cancer Center
2016-2019
University of Miami
2015-2019
University of Edinburgh
2006-2018
Sun Yat-sen University
2018
The First Affiliated Hospital, Sun Yat-sen University
2018
The Wistar Institute
1996-2014
Institute of Forest Ecology, Environment and Protection
2014
Chinese Academy of Forestry
2014
A dual role of the C9ORF72/SMCR8-containing complex in autophagy initiation and autophagic flux.
Zika virus (ZIKV) infection of pregnant women can result in fetal brain abnormalities. It has been established that ZIKV disrupts neural progenitor cells (NPCs) and leads to embryonic microcephaly. However, the fate other cell types developing their contributions ZIKV-associated abnormalities remain largely unknown. Using intracerebral inoculation mouse brains, we found postnatal growth restriction including In addition cycle arrest apoptosis NPCs, causes massive neuronal death axonal...
How self-renewal versus differentiation of neural progenitor cells is temporally controlled during early development remains ill-defined. We show that mouse Lin41 (mLin41) highly expressed in and its expression declines differentiation. Loss mLin41 function mice causes reduced proliferation premature embryonic cells. was recently implicated as the E3 ubiquitin ligase mediates degradation Argonaute 2 (AGO2), a key effector microRNA pathway. However, our mechanistic studies indicate not...
Survivin is a key cellular protein thought to function in apoptotic regulation, mitotic progression, or possibly both. In this study, we describe the isolation of two conditional knockouts survivin gene chicken DT40 cells. cells lacking die interphase after failing complete cytokinesis. However, these show normal sensitivity chemotherapeutic agent etoposide. Expression mutants against null background reassess role several residues reveals that can grow normally if their sole missing widely...
Summary Phosphate (P i ) is a major limiting factor for plant growth. Plants respond to P supplies by inducing suite of adaptive responses comprising altered growth behaviour, enhanced acquisition and reduced demand that together define distinct physiological state. In ‐starved plants, continued root required from new sources, yet meristem activity consumes . Therefore, we analysed the relationship between organ growth, phosphate starvation‐responsive (PSR) gene expression content in...
Activating mutations in the mitogen-activated protein kinase (MAPK) cascade, also known as RAS-MEK-extracellular signal-related (ERK1/2) pathway, are an underlying cause of >70% human cancers. While great strides have been made toward elucidating cytoplasmic components MAPK signaling, key downstream coactivators that coordinate transcriptional response not fully illustrated. Here, we demonstrate cells is funneled through Integrator, RNA polymerase II-associated complex. Integrator depletion...
Abstract PRAME is a CUL2 ubiquitin ligase subunit that normally expressed in the testis but becomes aberrantly overexpressed many cancer types association with aneuploidy and metastasis. Here, we show predominantly spermatogonia around time of meiotic crossing-over coordination genes mediating DNA double strand break repair. Expression somatic cells upregulates pathways involved meiosis, chromosome segregation repair, it leads to increased breaks, telomere dysfunction neoplastic...
AML1-ETO (AE) is a fusion transcription factor, generated by the t(8;21) translocation, that functions as leukemia promoting oncogene. Here, we demonstrate TATA-Box Binding Protein Associated Factor 1 (TAF1) associates with K43 acetylated AE and this association plays pivotal role in proliferation of AE-expressing acute myeloid (AML) cells. ChIP-sequencing indicates significant overlap TAF1 binding sites. Knockdown alters chromatin, affecting expression genes are activated or repressed AE....
Abstract Ribosomal frameshifting refers to the process that ribosomes slip into +1 or −1 reading frame, thus produce chimeric trans-frame proteins. In viruses and bacteria, programmed ribosomal can essential proteins for viral replication regulation of other biological processes. humans, however, functional protein derived from is scarcely documented. Combining multiple assays, we show short codon repeats could act as cis-acting elements stimulate in abbreviated CRFS hereafter. Using...
We engineered mutants into residues of SMC2 to dissect the role ATPase function in condensin complex. These are predicted be involved ATP binding or hydrolysis and Q-loop, which is thought act as a mediator conformational changes induced by substrate binding. All mutations resulted lethality when introduced null cells. found that binding, but not hydrolysis, essential allow stable association with chromosomes. How SMC proteins bind interact DNA still major question. Cohesin may form ring...
Phosphate starvation-mediated induction of the HAD-type phosphatases PPsPase1 (AT1G73010) and PECP1 (AT1G17710) has been reported in Arabidopsis (Arabidopsis thaliana). However, little is known about their vivo function or impact on plant responses to nutrient deficiency. The preferences for different substrates have studied vitro but require confirmation planta. Here, we examined both enzymes using a reverse genetics approach. We demonstrated that affect phosphocholine phosphoethanolamine...
Dry eye syndrome (DES) is a prevalent ocular disorder involving diminishe·d tear production and increased evaporation, leading to discomfort potential surface damage. Inflammation reactive oxygen species (ROS) have been implicated in the pathophysiology of DES. one core cause DES vicious cycle. Moreover, there are ROS that regulate inflammation cycle from upstream, which leads treatment failure current therapies merely target inflammation. In this study, we developed novel therapeutic...